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Thylakoids suppress appetite by increasing cholecystokinin resulting in lower food intake and body weight in high-fat fed mice.

Köhnke, Rickard LU ; Lindqvist, Andreas LU ; Göransson, Nathanael LU ; Emek, Sinan Cem LU ; Albertsson, Per-Åke LU ; Rehfeld, Jens F; Hultgårdh, Anna LU and Erlanson-Albertsson, Charlotte LU (2009) In Phytotherapy Research 23. p.1778-1783
Abstract
Thylakoids are membranes isolated from plant chloroplasts which have previously been shown to inhibit pancreatic lipase/colipase catalysed hydrolysis of fat in vitro and induce short-term satiety in vivo. The purpose of the present study was to examine if dietary supplementation of thylakoids could affect food intake and body weight during long-term feeding in mice. Female apolipoprotein E-deficient mice were fed a high-fat diet containing 41% of fat by energy with and without thylakoids for 100 days. Mice fed the thylakoid-enriched diet had suppressed food intake, body weight gain and body fat compared with the high-fat fed control mice. Reduced serum glucose, serum triglyceride and serum free fatty acid levels were found in the... (More)
Thylakoids are membranes isolated from plant chloroplasts which have previously been shown to inhibit pancreatic lipase/colipase catalysed hydrolysis of fat in vitro and induce short-term satiety in vivo. The purpose of the present study was to examine if dietary supplementation of thylakoids could affect food intake and body weight during long-term feeding in mice. Female apolipoprotein E-deficient mice were fed a high-fat diet containing 41% of fat by energy with and without thylakoids for 100 days. Mice fed the thylakoid-enriched diet had suppressed food intake, body weight gain and body fat compared with the high-fat fed control mice. Reduced serum glucose, serum triglyceride and serum free fatty acid levels were found in the thylakoid-treated animals. The satiety hormone cholecystokinin was elevated, suggesting this hormone mediates satiety. Leptin levels were reduced, reflecting a decreased fat mass. There was no sign of desensitization in the animals treated with thylakoids. The results suggest that thylakoids are useful to suppress appetite and body weight gain when supplemented to a high-fat food during long-term feeding. Copyright (c) 2009 John Wiley & Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Phytotherapy Research
volume
23
pages
1778 - 1783
publisher
John Wiley & Sons
external identifiers
  • wos:000272570300022
  • pmid:19548286
  • scopus:72349092837
ISSN
1099-1573
DOI
10.1002/ptr.2855
language
English
LU publication?
yes
id
21f22a52-3bed-45b6-935d-383c97030667 (old id 1433982)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19548286?dopt=Abstract
date added to LUP
2009-07-06 11:02:02
date last changed
2017-12-10 04:44:22
@article{21f22a52-3bed-45b6-935d-383c97030667,
  abstract     = {Thylakoids are membranes isolated from plant chloroplasts which have previously been shown to inhibit pancreatic lipase/colipase catalysed hydrolysis of fat in vitro and induce short-term satiety in vivo. The purpose of the present study was to examine if dietary supplementation of thylakoids could affect food intake and body weight during long-term feeding in mice. Female apolipoprotein E-deficient mice were fed a high-fat diet containing 41% of fat by energy with and without thylakoids for 100 days. Mice fed the thylakoid-enriched diet had suppressed food intake, body weight gain and body fat compared with the high-fat fed control mice. Reduced serum glucose, serum triglyceride and serum free fatty acid levels were found in the thylakoid-treated animals. The satiety hormone cholecystokinin was elevated, suggesting this hormone mediates satiety. Leptin levels were reduced, reflecting a decreased fat mass. There was no sign of desensitization in the animals treated with thylakoids. The results suggest that thylakoids are useful to suppress appetite and body weight gain when supplemented to a high-fat food during long-term feeding. Copyright (c) 2009 John Wiley & Sons, Ltd.},
  author       = {Köhnke, Rickard and Lindqvist, Andreas and Göransson, Nathanael and Emek, Sinan Cem and Albertsson, Per-Åke and Rehfeld, Jens F and Hultgårdh, Anna and Erlanson-Albertsson, Charlotte},
  issn         = {1099-1573},
  language     = {eng},
  pages        = {1778--1783},
  publisher    = {John Wiley & Sons},
  series       = {Phytotherapy Research},
  title        = {Thylakoids suppress appetite by increasing cholecystokinin resulting in lower food intake and body weight in high-fat fed mice.},
  url          = {http://dx.doi.org/10.1002/ptr.2855},
  volume       = {23},
  year         = {2009},
}