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Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European prospective investigation into cancer and nutrition (EPIC) study

Weikert, Cornelia; Dietrich, Thomas; Boeing, Heiner; Bergmann, Manuela M.; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Francoise; Allen, Naomi; Key, Tim; Lund, Eiliv and Olsen, Anja, et al. (2009) In International Journal of Cancer 125(2). p.406-412
Abstract
Recent alcohol consumption is all established risk factor for squamous cell carcinoma (SCC) or the upper aero-digestive tract. In contrast, the role or lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data oil alcohol use are available in 271,253 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 2,330,381 person years, 392 incident SCC cases (279 men and 113 women) were identified. Cox regression vas applied to model sex-specific associations between lifetime alcohol intake and SCC risk adjusting for potential confounders including smoking. Compared to men who drank 0.1-6.0 g/day alcohol at lifetime, the relative risks (RR) for developing SCC were... (More)
Recent alcohol consumption is all established risk factor for squamous cell carcinoma (SCC) or the upper aero-digestive tract. In contrast, the role or lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data oil alcohol use are available in 271,253 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 2,330,381 person years, 392 incident SCC cases (279 men and 113 women) were identified. Cox regression vas applied to model sex-specific associations between lifetime alcohol intake and SCC risk adjusting for potential confounders including smoking. Compared to men who drank 0.1-6.0 g/day alcohol at lifetime, the relative risks (RR) for developing SCC were significantly increased for men who drank 30.1-60.0 g/day (RR 1.65, 95% confidence interval: 1.00-2.71), 60.1-96.0 g/day (RR 2.20, 95%CI 1.23-3.95), and >96.0 g/day, (RR 4.63, 95% CI 2.52-8.48), and for former drinkers (RR 4.14, 95% CI 2.38-7.19). These risk estimates did not considerably change when baseline alcohol intake was analyzed. Compared to women who drank 0.1-6.0 g/day alcohol intake at lifetime, the RR were significantly increased for women who drank >30 g/d (RR 6.05, 95% CI 2.98-12.3). Applying similar categories, the relative risk for baseline alcohol intake was 3.26 (95%CI 1.82-5.87). We observed a stronger association between alcohol intake at lifetime and risk of SCC in women compared to men (p for interaction = 0.045). The strong dose-response relation for lifetime alcohol use underscores that alcohol is an important risk factor of SCC of the upper aero-digestive tract throughout life. (C) 2009 UICC (Less)
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publication status
published
subject
keywords
pharynx, oral cavity, larynx, esophagus, squamous cell carcinoma, cohort study, epidemiology
in
International Journal of Cancer
volume
125
issue
2
pages
406 - 412
publisher
John Wiley & Sons
external identifiers
  • wos:000267231600020
  • scopus:67449103802
ISSN
0020-7136
DOI
10.1002/ijc.24393
language
English
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yes
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75c6ab72-8905-4dee-ba08-58fea0f554ac (old id 1441349)
date added to LUP
2009-07-28 10:29:51
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2017-10-22 03:36:28
@article{75c6ab72-8905-4dee-ba08-58fea0f554ac,
  abstract     = {Recent alcohol consumption is all established risk factor for squamous cell carcinoma (SCC) or the upper aero-digestive tract. In contrast, the role or lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data oil alcohol use are available in 271,253 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 2,330,381 person years, 392 incident SCC cases (279 men and 113 women) were identified. Cox regression vas applied to model sex-specific associations between lifetime alcohol intake and SCC risk adjusting for potential confounders including smoking. Compared to men who drank 0.1-6.0 g/day alcohol at lifetime, the relative risks (RR) for developing SCC were significantly increased for men who drank 30.1-60.0 g/day (RR 1.65, 95% confidence interval: 1.00-2.71), 60.1-96.0 g/day (RR 2.20, 95%CI 1.23-3.95), and >96.0 g/day, (RR 4.63, 95% CI 2.52-8.48), and for former drinkers (RR 4.14, 95% CI 2.38-7.19). These risk estimates did not considerably change when baseline alcohol intake was analyzed. Compared to women who drank 0.1-6.0 g/day alcohol intake at lifetime, the RR were significantly increased for women who drank >30 g/d (RR 6.05, 95% CI 2.98-12.3). Applying similar categories, the relative risk for baseline alcohol intake was 3.26 (95%CI 1.82-5.87). We observed a stronger association between alcohol intake at lifetime and risk of SCC in women compared to men (p for interaction = 0.045). The strong dose-response relation for lifetime alcohol use underscores that alcohol is an important risk factor of SCC of the upper aero-digestive tract throughout life. (C) 2009 UICC},
  author       = {Weikert, Cornelia and Dietrich, Thomas and Boeing, Heiner and Bergmann, Manuela M. and Boutron-Ruault, Marie Christine and Clavel-Chapelon, Francoise and Allen, Naomi and Key, Tim and Lund, Eiliv and Olsen, Anja and Tjonneland, Anne and Overvad, Kim and Rohrmann, Sabine and Linseisen, Jakob and Pischon, Tobias and Trichopoulou, Antonia and Weinehall, Lars and Johansson, Ingegerd and Sanchez, Maria-Jose and Agudo, Antonio and Barricarte, Aurelio and Amiano, Pilar and Chirlaque, Maria-Dolores and Ramon Quiros, J. and Wirfält, Elisabet and Peeters, Petra H. and Bueno-de-Mesquita, H. Bas and Vrieling, Alina and Pala, Valeria and Palli, Domenico and Vineis, Paolo and Tumino, Rosario and Panico, Salvatore and Bingham, Sheila and Khaw, Kay-Tee and Norat, Teresa and Jenab, Mazda and Ferrari, Pietro and Slimani, Nadia and Riboli, Elio},
  issn         = {0020-7136},
  keyword      = {pharynx,oral cavity,larynx,esophagus,squamous cell carcinoma,cohort study,epidemiology},
  language     = {eng},
  number       = {2},
  pages        = {406--412},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European prospective investigation into cancer and nutrition (EPIC) study},
  url          = {http://dx.doi.org/10.1002/ijc.24393},
  volume       = {125},
  year         = {2009},
}