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Exposure to cadmium and persistent organochlorine pollutants and its association with bone mineral density and markers of bone metabolism on postmenopausal women.

Rignell-Hydbom, Anna LU ; Skerfving, Staffan LU ; Lundh, Thomas LU ; Lindh, Christian LU ; Elmståhl, Sölve LU ; Bjellerup, P; Jünsson, B A G; Strümberg, U and Akesson, A (2009) In Environmental Research 109. p.991-996
Abstract
Environmental contaminants such as cadmium and persistent organochlorine pollutants have been proposed as risk factors of osteoporosis, and women may be at an increased risk. To assess associations between exposure to cadmium and two different POPs (2,2',4,4',5,5'-hexachlorobiphenyl CB-153, 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene p,p'-DDE), on one hand, and bone effects, on the other, in a population-based study among postmenopausal (60-70 years) Swedish women with biobanked blood samples. The study included 908 women and was designed to have a large contrast of bone mineral densities, measured with a single photon absorptiometry technique in the non-dominant forearm. Biochemical markers related to bone metabolism were analyzed in... (More)
Environmental contaminants such as cadmium and persistent organochlorine pollutants have been proposed as risk factors of osteoporosis, and women may be at an increased risk. To assess associations between exposure to cadmium and two different POPs (2,2',4,4',5,5'-hexachlorobiphenyl CB-153, 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene p,p'-DDE), on one hand, and bone effects, on the other, in a population-based study among postmenopausal (60-70 years) Swedish women with biobanked blood samples. The study included 908 women and was designed to have a large contrast of bone mineral densities, measured with a single photon absorptiometry technique in the non-dominant forearm. Biochemical markers related to bone metabolism were analyzed in serum. Exposure assessment was based on cadmium concentrations in erythrocytes and serum concentrations of CB-153 and p,p'-DDE. Cadmium was negatively associated with bone mineral density and parathyroid hormone, positively with the marker of bone resorption. However, this association disappeared after adjustment for smoking. The major DDT metabolite (p,p'-DDE) was positively associated with bone mineral density, an association which remained after adjustment for confounders, but the effect was weak. There was no evidence that the estrogenic congener (CB-153) was associated with any of the bone markers. In conclusion, no convincing associations were observed between cadmium and POPs, on one hand, and bone metabolism markers and BMD, on the other. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Environmental Research
volume
109
pages
991 - 996
publisher
Elsevier
external identifiers
  • wos:000271296900007
  • pmid:19733845
  • scopus:70350435091
ISSN
1096-0953
DOI
10.1016/j.envres.2009.08.008
language
English
LU publication?
yes
id
5533f99f-cf9f-42db-86cd-5a9ad2cae7d8 (old id 1483701)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19733845?dopt=Abstract
date added to LUP
2009-10-07 09:15:17
date last changed
2017-08-06 04:46:58
@article{5533f99f-cf9f-42db-86cd-5a9ad2cae7d8,
  abstract     = {Environmental contaminants such as cadmium and persistent organochlorine pollutants have been proposed as risk factors of osteoporosis, and women may be at an increased risk. To assess associations between exposure to cadmium and two different POPs (2,2',4,4',5,5'-hexachlorobiphenyl CB-153, 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene p,p'-DDE), on one hand, and bone effects, on the other, in a population-based study among postmenopausal (60-70 years) Swedish women with biobanked blood samples. The study included 908 women and was designed to have a large contrast of bone mineral densities, measured with a single photon absorptiometry technique in the non-dominant forearm. Biochemical markers related to bone metabolism were analyzed in serum. Exposure assessment was based on cadmium concentrations in erythrocytes and serum concentrations of CB-153 and p,p'-DDE. Cadmium was negatively associated with bone mineral density and parathyroid hormone, positively with the marker of bone resorption. However, this association disappeared after adjustment for smoking. The major DDT metabolite (p,p'-DDE) was positively associated with bone mineral density, an association which remained after adjustment for confounders, but the effect was weak. There was no evidence that the estrogenic congener (CB-153) was associated with any of the bone markers. In conclusion, no convincing associations were observed between cadmium and POPs, on one hand, and bone metabolism markers and BMD, on the other.},
  author       = {Rignell-Hydbom, Anna and Skerfving, Staffan and Lundh, Thomas and Lindh, Christian and Elmståhl, Sölve and Bjellerup, P and Jünsson, B A G and Strümberg, U and Akesson, A},
  issn         = {1096-0953},
  language     = {eng},
  pages        = {991--996},
  publisher    = {Elsevier},
  series       = {Environmental Research},
  title        = {Exposure to cadmium and persistent organochlorine pollutants and its association with bone mineral density and markers of bone metabolism on postmenopausal women.},
  url          = {http://dx.doi.org/10.1016/j.envres.2009.08.008},
  volume       = {109},
  year         = {2009},
}