Advanced

Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Buchner, F. L.; Bueno-de-Mesquita, H. B.; Linseisen, J.; Boshuizen, H. C.; Kiemeney, L. A. L. M.; Ros, M. M.; Overvad, K.; Hansen, L.; Tjonneland, A. and Raaschou-Nielsen, O., et al. (2010) In Cancer Causes and Control 21(3). p.357-371
Abstract
Objective To examine the association between fruit and vegetable consumption and risk of different histological subtypes of lung cancer among participants of the European Prospective Investigation into Cancer and Nutrition study. Methods Multivariable Cox proportional hazard models were used to analyze the data. A calibration study in a subsample was used to reduce dietary measurement errors. Results During a mean follow-up of 8.7 years, 1,830 incident cases of lung cancer (574 adenocarcinoma, 286 small cell, 137 large cell, 363 squamous cell, 470 other histologies) were identified. In line with our previous conclusions, we found that after calibration a 100 g/day increase in fruit and vegetables consumption was associated with a reduced... (More)
Objective To examine the association between fruit and vegetable consumption and risk of different histological subtypes of lung cancer among participants of the European Prospective Investigation into Cancer and Nutrition study. Methods Multivariable Cox proportional hazard models were used to analyze the data. A calibration study in a subsample was used to reduce dietary measurement errors. Results During a mean follow-up of 8.7 years, 1,830 incident cases of lung cancer (574 adenocarcinoma, 286 small cell, 137 large cell, 363 squamous cell, 470 other histologies) were identified. In line with our previous conclusions, we found that after calibration a 100 g/day increase in fruit and vegetables consumption was associated with a reduced lung cancer risk (HR 0.94; 95% CI 0.89-0.99). This was also seen among current smokers (HR 0.93; 95% CI 0.90-0.97). Risks of squamous cell carcinomas in current smokers were reduced for an increase of 100 g/day of fruit and vegetables combined (HR 0.85; 95% CI 0.76-0.94), while no clear effects were seen for the other histological subtypes. Conclusion We observed inverse associations between the consumption of vegetables and fruits and risk of lung cancer without a clear effect on specific histological subtypes of lung cancer. In current smokers, consumption of vegetables and fruits may reduce lung cancer risk, in particular the risk of squamous cell carcinomas. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Large cell carcinoma, Adenocarcinoma, Non-small-cell lung carcinoma, Small cell lung carcinoma, Lung neoplasms, Fruits, Vegetables
in
Cancer Causes and Control
volume
21
issue
3
pages
357 - 371
publisher
Springer
external identifiers
  • wos:000275921300004
  • scopus:77950691299
ISSN
1573-7225
DOI
10.1007/s10552-009-9468-y
language
English
LU publication?
yes
id
2b3e13ea-7bd1-48bb-b49c-afd2a8847476 (old id 1587812)
date added to LUP
2010-04-22 14:51:18
date last changed
2018-05-29 10:12:30
@article{2b3e13ea-7bd1-48bb-b49c-afd2a8847476,
  abstract     = {Objective To examine the association between fruit and vegetable consumption and risk of different histological subtypes of lung cancer among participants of the European Prospective Investigation into Cancer and Nutrition study. Methods Multivariable Cox proportional hazard models were used to analyze the data. A calibration study in a subsample was used to reduce dietary measurement errors. Results During a mean follow-up of 8.7 years, 1,830 incident cases of lung cancer (574 adenocarcinoma, 286 small cell, 137 large cell, 363 squamous cell, 470 other histologies) were identified. In line with our previous conclusions, we found that after calibration a 100 g/day increase in fruit and vegetables consumption was associated with a reduced lung cancer risk (HR 0.94; 95% CI 0.89-0.99). This was also seen among current smokers (HR 0.93; 95% CI 0.90-0.97). Risks of squamous cell carcinomas in current smokers were reduced for an increase of 100 g/day of fruit and vegetables combined (HR 0.85; 95% CI 0.76-0.94), while no clear effects were seen for the other histological subtypes. Conclusion We observed inverse associations between the consumption of vegetables and fruits and risk of lung cancer without a clear effect on specific histological subtypes of lung cancer. In current smokers, consumption of vegetables and fruits may reduce lung cancer risk, in particular the risk of squamous cell carcinomas.},
  author       = {Buchner, F. L. and Bueno-de-Mesquita, H. B. and Linseisen, J. and Boshuizen, H. C. and Kiemeney, L. A. L. M. and Ros, M. M. and Overvad, K. and Hansen, L. and Tjonneland, A. and Raaschou-Nielsen, O. and Clavel-Chapelon, F. and Boutron-Ruault, M. -C. and Touillaud, M. and Kaaks, R. and Rohrmann, S. and Boeing, H. and Noethlings, U. and Trichopoulou, A. and Zylis, D. and Dilis, V. and Palli, D. and Sieri, S. and Vineis, P. and Tumino, R. and Panico, S. and Peeters, P. H. M. and van Gils, C. H. and Lund, E. and Gram, I. T. and Braaten, T. and Martinez, C. and Agudo, A. and Arriola, L. and Ardanaz, E. and Navarro, C. and Rodriguez, L. and Manjer, Jonas and Wirfält, Elisabet and Hallmans, G. and Rasmuson, T. and Key, T. J. and Roddam, A. W. and Bingham, S. and Khaw, K. -T. and Slimani, N. and Bofetta, P. and Byrnes, G. and Norat, T. and Michaud, D. and Riboli, E.},
  issn         = {1573-7225},
  keyword      = {Large cell carcinoma,Adenocarcinoma,Non-small-cell lung carcinoma,Small cell lung carcinoma,Lung neoplasms,Fruits,Vegetables},
  language     = {eng},
  number       = {3},
  pages        = {357--371},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1007/s10552-009-9468-y},
  volume       = {21},
  year         = {2010},
}