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High-fat diet impairs hippocampal neurogenesis in male rats.

Lindqvist, Andreas LU ; Mohapel, Paul LU ; Bouter, B ; Frielingsdorf, Helena LU ; Pizzo, D ; Brundin, Patrik LU and Erlanson-Albertsson, Charlotte LU (2006) In European Journal of Neurology 13(12). p.1385-1388
Abstract
High fat diets and obesity pose serious health problems, such as type II diabetes and cardiovascular disease. Impaired cognitive function is also associated with high fat intake. In this study, we show that just 4 weeks of feeding a diet rich in fat ad libitum decreased hippocampal neurogenesis in male, but not female, rats. There was no obesity, but male rats fed a diet rich in fat exhibited elevated serum corticosterone levels compared with those fed standard rat chow. These data indicate that high dietary fat intake can disrupt hippocampal neurogenesis, probably through an increase in serum corticosterone levels, and that males are more susceptible than females.
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
fat intake, obesity, memory, hippocampus, corticosterone
in
European Journal of Neurology
volume
13
issue
12
pages
1385 - 1388
publisher
Wiley-Blackwell
external identifiers
  • wos:000241953100024
  • scopus:33750948034
ISSN
1351-5101
DOI
10.1111/j.1468-1331.2006.01500.x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuroendocrine Cell Biology (013241501), Endocrinology (013241500), Neuronal Survival (013212041), Apetite Regulation (013212030), Wallenberg Neuroscience Centre, Lund (0131000110)
id
5bbf20b1-d302-45b3-a6c2-f7b5f78bd0bb (old id 163110)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17116226&dopt=Abstract
date added to LUP
2016-04-01 11:48:48
date last changed
2021-09-29 04:31:43
@article{5bbf20b1-d302-45b3-a6c2-f7b5f78bd0bb,
  abstract     = {High fat diets and obesity pose serious health problems, such as type II diabetes and cardiovascular disease. Impaired cognitive function is also associated with high fat intake. In this study, we show that just 4 weeks of feeding a diet rich in fat ad libitum decreased hippocampal neurogenesis in male, but not female, rats. There was no obesity, but male rats fed a diet rich in fat exhibited elevated serum corticosterone levels compared with those fed standard rat chow. These data indicate that high dietary fat intake can disrupt hippocampal neurogenesis, probably through an increase in serum corticosterone levels, and that males are more susceptible than females.},
  author       = {Lindqvist, Andreas and Mohapel, Paul and Bouter, B and Frielingsdorf, Helena and Pizzo, D and Brundin, Patrik and Erlanson-Albertsson, Charlotte},
  issn         = {1351-5101},
  language     = {eng},
  number       = {12},
  pages        = {1385--1388},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Neurology},
  title        = {High-fat diet impairs hippocampal neurogenesis in male rats.},
  url          = {https://lup.lub.lu.se/search/files/2653075/625751.pdf},
  doi          = {10.1111/j.1468-1331.2006.01500.x},
  volume       = {13},
  year         = {2006},
}