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Physical Activity and Breast Cancer Risk: The European Prospective Investigation into Cancer and Nutrition.

Lahmann, Petra H; Friedenreich, Christine; Schuit, A Jantine; Salvini, Simonetta; Allen, Naomi E; Key, Tim J; Khaw, Kay-Tee; Bingham, Sheila; Peeters, Petra H M and Monninkhof, Evelyn, et al. (2007) In Cancer Epidemiology Biomarkers & Prevention 16(1). p.36-42
Abstract
There is convincing evidence for a decreased risk of breast cancer with increased physical activity. Uncertainties remain, however, about the role of different types of physical activity on breast cancer risk and the potential effect modification for these associations. We used data from 218,169 premenopausal and postmenopausal women from nine European countries, ages 20 to 80 years at study entry into the European Prospective Investigation into Cancer and Nutrition. Hazard ratios (HR) from multivariate Cox regression models were calculated using metabolic equivalent value-based physical activity variables categorized in quartiles, adjusted for age, study center, education, body mass index, smoking, alcohol use, age at menarche, age at... (More)
There is convincing evidence for a decreased risk of breast cancer with increased physical activity. Uncertainties remain, however, about the role of different types of physical activity on breast cancer risk and the potential effect modification for these associations. We used data from 218,169 premenopausal and postmenopausal women from nine European countries, ages 20 to 80 years at study entry into the European Prospective Investigation into Cancer and Nutrition. Hazard ratios (HR) from multivariate Cox regression models were calculated using metabolic equivalent value-based physical activity variables categorized in quartiles, adjusted for age, study center, education, body mass index, smoking, alcohol use, age at menarche, age at first pregnancy, parity, current oral contraceptive use, and hormone replacement therapy use. The physical activity assessment included recreational, household, and occupational activities. A total physical activity index was estimated based on cross-tabulation of these separate types of activity. During 6.4 years of follow-up, 3,423 incident invasive breast cancers were identified. Overall, increasing total physical activity was associated with a reduction in breast cancer risk among postmenopausal women (P-trend = 0.06). Specifically, household activity was associated with a significantly reduced risk in postmenopausal (HR, 0.81; 95% confidence interval, 0.70-0.93, highest versus the lowest quartile; P-trend = 0.001) and premenopausal (HR, 0.71; 95% confidence interval, 0.55-0.90, highest versus lowest quartile; P-trend = 0.003) women. Occupational activity and recreational activity were not significantly related to breast cancer risk in both premenopausal and postmenopausal women. This study provides additional evidence for a protective effect of physical activity on breast cancer risk. (Less)
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Cancer Epidemiology Biomarkers & Prevention
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16
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1
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36 - 42
publisher
American Association for Cancer Research
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  • wos:000243550100007
  • scopus:33846622115
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-06-0582
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English
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3f254ba6-7b76-4a53-8281-259bab02e9aa (old id 163840)
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17179488&dopt=Abstract
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@article{3f254ba6-7b76-4a53-8281-259bab02e9aa,
  abstract     = {There is convincing evidence for a decreased risk of breast cancer with increased physical activity. Uncertainties remain, however, about the role of different types of physical activity on breast cancer risk and the potential effect modification for these associations. We used data from 218,169 premenopausal and postmenopausal women from nine European countries, ages 20 to 80 years at study entry into the European Prospective Investigation into Cancer and Nutrition. Hazard ratios (HR) from multivariate Cox regression models were calculated using metabolic equivalent value-based physical activity variables categorized in quartiles, adjusted for age, study center, education, body mass index, smoking, alcohol use, age at menarche, age at first pregnancy, parity, current oral contraceptive use, and hormone replacement therapy use. The physical activity assessment included recreational, household, and occupational activities. A total physical activity index was estimated based on cross-tabulation of these separate types of activity. During 6.4 years of follow-up, 3,423 incident invasive breast cancers were identified. Overall, increasing total physical activity was associated with a reduction in breast cancer risk among postmenopausal women (P-trend = 0.06). Specifically, household activity was associated with a significantly reduced risk in postmenopausal (HR, 0.81; 95% confidence interval, 0.70-0.93, highest versus the lowest quartile; P-trend = 0.001) and premenopausal (HR, 0.71; 95% confidence interval, 0.55-0.90, highest versus lowest quartile; P-trend = 0.003) women. Occupational activity and recreational activity were not significantly related to breast cancer risk in both premenopausal and postmenopausal women. This study provides additional evidence for a protective effect of physical activity on breast cancer risk.},
  author       = {Lahmann, Petra H and Friedenreich, Christine and Schuit, A Jantine and Salvini, Simonetta and Allen, Naomi E and Key, Tim J and Khaw, Kay-Tee and Bingham, Sheila and Peeters, Petra H M and Monninkhof, Evelyn and Bueno-de-Mesquita, H Bas and Wirfält, Elisabet and Manjer, Jonas and Gonzales, Carlos A and Ardanaz, Eva and Amiano, Pilar and Quirós, José R and Navarro, Carmen and Martinez, Carmen and Berrino, Franco and Palli, Domenico and Tumino, Rosario and Panico, Salvatore and Vineis, Paolo and Trichopoulou, Antonia and Bamia, Christina and Trichopoulos, Dimitrios and Boeing, Heiner and Schulz, Mandy and Linseisen, Jakob and Chang-Claude, Jenny and Chapelon, Francoise Clavel and Fournier, Agnès and Boutron-Ruault, Marie-Christine and Tjonneland, Anne and Johnson, Nina Føns and Overvad, Kim and Kaaks, Rudolf and Riboli, Elio},
  issn         = {1538-7755},
  language     = {eng},
  number       = {1},
  pages        = {36--42},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Physical Activity and Breast Cancer Risk: The European Prospective Investigation into Cancer and Nutrition.},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-06-0582},
  volume       = {16},
  year         = {2007},
}