Environment Matters: Synaptic Properties of Neurons Born in the Epileptic Adult Brain Develop to Reduce Excitability.
Jakubs, Katherine LU ; Nanobashvili, Avtandil LU ; Bonde, Sara LU ; Ekdahl Clementson, Christine LU ; Kokaia, Zaal LU
; Kokaia, Merab
LU
and Lindvall, Olle
LU
(2006)
In Neuron
52(6).
p.1047-1059
- Abstract
- Neural progenitors in the adult dentate gyrus continuously produce new functional granule cells. Here we used whole-cell patch-clamp recordings to explore whether a pathological environment influences synaptic properties of new granule cells labeled with a GFP-retroviral vector. Rats were exposed to a physiological stimulus, i.e., running, or a brain insult, i.e., status epilepticus, which gave rise to neuronal death, inflammation, and chronic seizures. Granule cells formed after these stimuli exhibited similar intrinsic membrane properties. However, the new neurons born into the pathological environment differed with respect to synaptic drive and short-term plasticity of both excitatory and inhibitory afferents. The new granule cells... (More)
- Neural progenitors in the adult dentate gyrus continuously produce new functional granule cells. Here we used whole-cell patch-clamp recordings to explore whether a pathological environment influences synaptic properties of new granule cells labeled with a GFP-retroviral vector. Rats were exposed to a physiological stimulus, i.e., running, or a brain insult, i.e., status epilepticus, which gave rise to neuronal death, inflammation, and chronic seizures. Granule cells formed after these stimuli exhibited similar intrinsic membrane properties. However, the new neurons born into the pathological environment differed with respect to synaptic drive and short-term plasticity of both excitatory and inhibitory afferents. The new granule cells formed in the epileptic brain exhibited functional connectivity consistent with reduced excitability. We demonstrate a high degree of plasticity in synaptic inputs to adult-born new neurons, which could act to mitigate pathological brain function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/163887
- author
- Jakubs, Katherine
LU
; Nanobashvili, Avtandil
LU
; Bonde, Sara
LU
; Ekdahl Clementson, Christine
LU
; Kokaia, Zaal
LU
; Kokaia, Merab
LU
and Lindvall, Olle
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neuron
- volume
- 52
- issue
- 6
- pages
- 1047 - 1059
- publisher
- Cell Press
- external identifiers
-
- wos:000243115100012
- scopus:33845414645
- ISSN
- 0896-6273
- DOI
- 10.1016/j.neuron.2006.11.004
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Stem Cell Center (013041110), Restorative Neurology (0131000160), Neurology, Lund (013027000), Epilepsy Center (013230801)
- id
- b38149cf-edca-4818-a2a9-21cf7e4b40b4 (old id 163887)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17178407&dopt=Abstract
- date added to LUP
- 2016-04-01 12:13:50
- date last changed
- 2022-03-28 22:02:22
@article{b38149cf-edca-4818-a2a9-21cf7e4b40b4,
abstract = {{Neural progenitors in the adult dentate gyrus continuously produce new functional granule cells. Here we used whole-cell patch-clamp recordings to explore whether a pathological environment influences synaptic properties of new granule cells labeled with a GFP-retroviral vector. Rats were exposed to a physiological stimulus, i.e., running, or a brain insult, i.e., status epilepticus, which gave rise to neuronal death, inflammation, and chronic seizures. Granule cells formed after these stimuli exhibited similar intrinsic membrane properties. However, the new neurons born into the pathological environment differed with respect to synaptic drive and short-term plasticity of both excitatory and inhibitory afferents. The new granule cells formed in the epileptic brain exhibited functional connectivity consistent with reduced excitability. We demonstrate a high degree of plasticity in synaptic inputs to adult-born new neurons, which could act to mitigate pathological brain function.}},
author = {{Jakubs, Katherine and Nanobashvili, Avtandil and Bonde, Sara and Ekdahl Clementson, Christine and Kokaia, Zaal and Kokaia, Merab and Lindvall, Olle}},
issn = {{0896-6273}},
language = {{eng}},
number = {{6}},
pages = {{1047--1059}},
publisher = {{Cell Press}},
series = {{Neuron}},
title = {{Environment Matters: Synaptic Properties of Neurons Born in the Epileptic Adult Brain Develop to Reduce Excitability.}},
url = {{http://dx.doi.org/10.1016/j.neuron.2006.11.004}},
doi = {{10.1016/j.neuron.2006.11.004}},
volume = {{52}},
year = {{2006}},
}