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Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition cohort study.

Michaud, Dominique S; Gallo, Valentina; Schlehofer, Brigitte; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Dahm, Christina C; Teucher, Birgit; Lukanova, Annekatrin and Boeing, Heiner, et al. (2010) In American Journal of Clinical Nutrition 92(5). p.1145-1150
Abstract
BACKGROUND: In a recent US cohort study, total coffee and tea consumption was inversely associated with risk of glioma, and experimental studies showed that caffeine can slow the invasive growth of glioblastoma. OBJECTIVE: The objective was to examine the relation between coffee and tea intake and the risk of glioma and meningioma in a large European cohort study, the European Prospective Investigation into Cancer and Nutrition (EPIC). DESIGN: Data on coffee and tea intake were collected from men and women recruited into the EPIC cohort study. Over an average of 8.5 y of follow-up, 343 cases of glioma and 245 cases of meningioma were newly diagnosed in 9 countries. We used Cox proportional hazards models to examine the relation between... (More)
BACKGROUND: In a recent US cohort study, total coffee and tea consumption was inversely associated with risk of glioma, and experimental studies showed that caffeine can slow the invasive growth of glioblastoma. OBJECTIVE: The objective was to examine the relation between coffee and tea intake and the risk of glioma and meningioma in a large European cohort study, the European Prospective Investigation into Cancer and Nutrition (EPIC). DESIGN: Data on coffee and tea intake were collected from men and women recruited into the EPIC cohort study. Over an average of 8.5 y of follow-up, 343 cases of glioma and 245 cases of meningioma were newly diagnosed in 9 countries. We used Cox proportional hazards models to examine the relation between coffee and tea and brain tumors. RESULTS: We observed no associations between coffee, tea, or combined coffee and tea consumption and risk of either type of brain tumor when using quantiles based on country-specific distributions of intake. However, a significant inverse association was observed for glioma risk among those consuming ≥100 mL coffee and tea per day compared with those consuming <100 mL/d (hazard ratio: 0.66; 95% CI: 0.44, 0.97; P = 0.03). The association was slightly stronger in men (hazard ratio: 0.59; 95% CI: 0.34, 1.01) than in women (hazard ratio: 0.74; 95% CI: 0.42, 1.31), although neither was statistically significant. CONCLUSIONS: In this large cohort study, we observed an inverse association between total coffee and tea consumption and risk of glioma that was consistent with the findings of a recent study. These findings, if further replicated in other studies, may provide new avenues of research on gliomas. (Less)
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American Journal of Clinical Nutrition
volume
92
issue
5
pages
1145 - 1150
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000283969000018
  • pmid:20844074
  • scopus:78149257704
ISSN
1938-3207
DOI
10.3945/ajcn.2010.29876
language
English
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yes
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8c4030a5-4d5b-4dff-9e1f-e17564ab83b8 (old id 1688207)
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http://www.ncbi.nlm.nih.gov/pubmed/20844074?dopt=Abstract
date added to LUP
2010-10-05 09:40:37
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2018-07-22 03:42:59
@article{8c4030a5-4d5b-4dff-9e1f-e17564ab83b8,
  abstract     = {BACKGROUND: In a recent US cohort study, total coffee and tea consumption was inversely associated with risk of glioma, and experimental studies showed that caffeine can slow the invasive growth of glioblastoma. OBJECTIVE: The objective was to examine the relation between coffee and tea intake and the risk of glioma and meningioma in a large European cohort study, the European Prospective Investigation into Cancer and Nutrition (EPIC). DESIGN: Data on coffee and tea intake were collected from men and women recruited into the EPIC cohort study. Over an average of 8.5 y of follow-up, 343 cases of glioma and 245 cases of meningioma were newly diagnosed in 9 countries. We used Cox proportional hazards models to examine the relation between coffee and tea and brain tumors. RESULTS: We observed no associations between coffee, tea, or combined coffee and tea consumption and risk of either type of brain tumor when using quantiles based on country-specific distributions of intake. However, a significant inverse association was observed for glioma risk among those consuming ≥100 mL coffee and tea per day compared with those consuming &lt;100 mL/d (hazard ratio: 0.66; 95% CI: 0.44, 0.97; P = 0.03). The association was slightly stronger in men (hazard ratio: 0.59; 95% CI: 0.34, 1.01) than in women (hazard ratio: 0.74; 95% CI: 0.42, 1.31), although neither was statistically significant. CONCLUSIONS: In this large cohort study, we observed an inverse association between total coffee and tea consumption and risk of glioma that was consistent with the findings of a recent study. These findings, if further replicated in other studies, may provide new avenues of research on gliomas.},
  author       = {Michaud, Dominique S and Gallo, Valentina and Schlehofer, Brigitte and Tjønneland, Anne and Olsen, Anja and Overvad, Kim and Dahm, Christina C and Teucher, Birgit and Lukanova, Annekatrin and Boeing, Heiner and Schütze, Madlen and Trichopoulou, Antonia and Lagiou, Pagona and Kyrozis, Andreas and Sacerdote, Carlotta and Krogh, Vittorio and Masala, Giovanna and Tumino, Rosario and Mattiello, Amalia and Bueno-de-Mesquita, H Bas and Ros, Martine M and Peeters, Petra Hm and van Gils, Carla H and Skeie, Guri and Engeset, Dagrun and Parr, Christine L and Ardanaz, Eva and Chirlaque, Maria-Dolores and Dorronsoro, Miren and Sánchez, Maria José and Argüelles, Marcial and Jakszyn, Paula and Nilsson, Lena and Melin, Beatrice S and Manjer, Jonas and Wirfält, Elisabet and Khaw, Kay-Tee and Wareham, Nick and Allen, Naomi E and Key, Timothy J and Romieu, Isabelle and Vineis, Paolo and Riboli, Elio},
  issn         = {1938-3207},
  language     = {eng},
  number       = {5},
  pages        = {1145--1150},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition cohort study.},
  url          = {http://dx.doi.org/10.3945/ajcn.2010.29876},
  volume       = {92},
  year         = {2010},
}