Advanced

Combined Clinical and Radiological Prognostic Model in Acute Ischemic Stroke

Abul-Kasim, Kasim LU ; Brizzi, Marco LU ; Petersson, Jesper LU ; Buchwald, Fredrik LU and Sundgren, Pia LU (2010) In Acta Neurologica Belgica 110(3). p.239-245
Abstract
We sought to propose and test the validity of a comprehensive prognostic model in middle cerebral artery-stroke treated with Intravenous thrombolysis. A total of 127 consecutive patients (aged 70 +/- 12 years; 54% males) were included in this retrospective study. Variables included in our prognostic model were: NIHSS on admission (1-3 points), occurrence of hyperdense middle cerebral artery sign and early ischemic signs on baseline CT (1 point each). NIHSS at 24 hours (0-3 points), posttreatment hemorrhage (1 point), and infarct volume (0-4 points). The score range teas 1-13, with higher values suggest unfavorable prognosis. Our prognostic score was correlated with the modified Rankin scale (mRS) at 3 months after stroke [correlation... (More)
We sought to propose and test the validity of a comprehensive prognostic model in middle cerebral artery-stroke treated with Intravenous thrombolysis. A total of 127 consecutive patients (aged 70 +/- 12 years; 54% males) were included in this retrospective study. Variables included in our prognostic model were: NIHSS on admission (1-3 points), occurrence of hyperdense middle cerebral artery sign and early ischemic signs on baseline CT (1 point each). NIHSS at 24 hours (0-3 points), posttreatment hemorrhage (1 point), and infarct volume (0-4 points). The score range teas 1-13, with higher values suggest unfavorable prognosis. Our prognostic score was correlated with the modified Rankin scale (mRS) at 3 months after stroke [correlation coefficient of 0.62, P < 0.001] and can thus help early prediction of the functional outcome. Logistic regression showed that NIHSS at 24 hours and EICs on baseline CT were independent predictor of our prognostic score (adjusted odds ratio of 4.1 and 5). Adopting a cut-off value of prognostic score <= 3 for favorable prognosis and >= 7 for unfavorable prognosis helped to predict the need for institutionalization and the functional outcome with higher accuracy and predictive values compared with using scores only based on NIHSS. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
volume, infarct, computed tomography, acute ischemic stroke, prognostic score, favorable prognosis, cut-off values
in
Acta Neurologica Belgica
volume
110
issue
3
pages
239 - 245
publisher
Acta Medica Belgica
external identifiers
  • wos:000283706900005
  • pmid:21114132
  • scopus:79952113723
ISSN
2240-2993
language
English
LU publication?
yes
id
1a135daa-feb0-4e6f-95ad-470f8c636f3c (old id 1720203)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21114132?dopt=Abstract
date added to LUP
2010-12-01 11:20:08
date last changed
2018-05-29 11:13:40
@article{1a135daa-feb0-4e6f-95ad-470f8c636f3c,
  abstract     = {We sought to propose and test the validity of a comprehensive prognostic model in middle cerebral artery-stroke treated with Intravenous thrombolysis. A total of 127 consecutive patients (aged 70 +/- 12 years; 54% males) were included in this retrospective study. Variables included in our prognostic model were: NIHSS on admission (1-3 points), occurrence of hyperdense middle cerebral artery sign and early ischemic signs on baseline CT (1 point each). NIHSS at 24 hours (0-3 points), posttreatment hemorrhage (1 point), and infarct volume (0-4 points). The score range teas 1-13, with higher values suggest unfavorable prognosis. Our prognostic score was correlated with the modified Rankin scale (mRS) at 3 months after stroke [correlation coefficient of 0.62, P &lt; 0.001] and can thus help early prediction of the functional outcome. Logistic regression showed that NIHSS at 24 hours and EICs on baseline CT were independent predictor of our prognostic score (adjusted odds ratio of 4.1 and 5). Adopting a cut-off value of prognostic score &lt;= 3 for favorable prognosis and &gt;= 7 for unfavorable prognosis helped to predict the need for institutionalization and the functional outcome with higher accuracy and predictive values compared with using scores only based on NIHSS.},
  author       = {Abul-Kasim, Kasim and Brizzi, Marco and Petersson, Jesper and Buchwald, Fredrik and Sundgren, Pia},
  issn         = {2240-2993},
  keyword      = {volume,infarct,computed tomography,acute ischemic stroke,prognostic score,favorable prognosis,cut-off values},
  language     = {eng},
  number       = {3},
  pages        = {239--245},
  publisher    = {Acta Medica Belgica},
  series       = {Acta Neurologica Belgica},
  title        = {Combined Clinical and Radiological Prognostic Model in Acute Ischemic Stroke},
  volume       = {110},
  year         = {2010},
}