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Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

Tsilidis, K. K.; Allen, N. E.; Key, T. J.; Bakken, K.; Lund, E.; Berrino, F.; Fournier, A.; Olsen, A.; Tjonneland, A. and Overvad, K., et al. (2010) In British Journal of Cancer 103(11). p.1755-1759
Abstract
BACKGROUND: Oral contraceptive use and reproductive factors may initiate long-term changes to the hormonal milieu and thereby, possibly influence colorectal cancer risk. METHODS: We examined the association of hormonal and reproductive factors with risk of colorectal cancer among 337 802 women in the European Prospective Investigation into Cancer and Nutrition, of whom 1878 developed colorectal cancer. RESULTS: After stratification for center and age, and adjustment for body mass index, smoking, diabetes mellitus, physical activity and alcohol consumption, ever use of oral contraceptives was marginally inversely associated with colorectal cancer risk (hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.83-1.02), although this... (More)
BACKGROUND: Oral contraceptive use and reproductive factors may initiate long-term changes to the hormonal milieu and thereby, possibly influence colorectal cancer risk. METHODS: We examined the association of hormonal and reproductive factors with risk of colorectal cancer among 337 802 women in the European Prospective Investigation into Cancer and Nutrition, of whom 1878 developed colorectal cancer. RESULTS: After stratification for center and age, and adjustment for body mass index, smoking, diabetes mellitus, physical activity and alcohol consumption, ever use of oral contraceptives was marginally inversely associated with colorectal cancer risk (hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.83-1.02), although this association was stronger among post-menopausal women (HR, 0.84; 95% CI: 0.74-0.95). Duration of oral contraceptive use and reproductive factors, including age at menarche, age at menopause, type of menopause, ever having an abortion, parity, age at first full-term pregnancy and breastfeeding, were not associated with colorectal cancer risk. CONCLUSION: Our findings provide limited support for a potential inverse association between oral contraceptives and colorectal cancer risk. British Journal of Cancer (2010) 103, 1755-1759. doi:10.1038/sj.bjc.6605965 www.bjcancer.com Published online 2 November 2010 (C) 2010 Cancer Research UK (Less)
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@article{24a6fae5-11dc-4a19-931c-6314cac98b6d,
  abstract     = {BACKGROUND: Oral contraceptive use and reproductive factors may initiate long-term changes to the hormonal milieu and thereby, possibly influence colorectal cancer risk. METHODS: We examined the association of hormonal and reproductive factors with risk of colorectal cancer among 337 802 women in the European Prospective Investigation into Cancer and Nutrition, of whom 1878 developed colorectal cancer. RESULTS: After stratification for center and age, and adjustment for body mass index, smoking, diabetes mellitus, physical activity and alcohol consumption, ever use of oral contraceptives was marginally inversely associated with colorectal cancer risk (hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.83-1.02), although this association was stronger among post-menopausal women (HR, 0.84; 95% CI: 0.74-0.95). Duration of oral contraceptive use and reproductive factors, including age at menarche, age at menopause, type of menopause, ever having an abortion, parity, age at first full-term pregnancy and breastfeeding, were not associated with colorectal cancer risk. CONCLUSION: Our findings provide limited support for a potential inverse association between oral contraceptives and colorectal cancer risk. British Journal of Cancer (2010) 103, 1755-1759. doi:10.1038/sj.bjc.6605965 www.bjcancer.com Published online 2 November 2010 (C) 2010 Cancer Research UK},
  author       = {Tsilidis, K. K. and Allen, N. E. and Key, T. J. and Bakken, K. and Lund, E. and Berrino, F. and Fournier, A. and Olsen, A. and Tjonneland, A. and Overvad, K. and Boutron-Ruault, M-C and Clavel-Chapelon, F. and Byrnes, G. and Chajes, V. and Rinaldi, S. and Chang-Claude, J. and Kaaks, R. and Bergmann, M. and Boeing, H. and Koumantaki, Y. and Stasinopoulou, G. and Trichopoulou, A. and Palli, D. and Tagliabue, G. and Panico, S. and Tumino, R. and Vineis, P. and Bueno-de-Mesquita, H. B. and van Duijnhoven, F. J. B. and van Gils, C. H. and Peeters, P. H. M. and Rodriguez, L. and Gonzalez, C. A. and Sanchez, M-J and Chirlaque, M-D and Barricarte, A. and Dorronsoro, M. and Borgquist, Signe and Manjer, Jonas and van Guelpen, B. and Hallmans, G. and Rodwell, S. A. and Khaw, K-T and Norat, T. and Romaguera, D. and Riboli, E.},
  issn         = {1532-1827},
  keyword      = {cohort,colorectal cancer,oral contraceptives,reproductive history,study},
  language     = {eng},
  number       = {11},
  pages        = {1755--1759},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1038/sj.bjc.6605965},
  volume       = {103},
  year         = {2010},
}