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Fish consumption and myocardial infarction: a second prospective biomarker study from northern Sweden

Wennberg, Maria; Bergdahl, Ingvar A.; Hallmans, Goran; Norberg, Margareta; Lundh, Thomas LU ; Skerfving, Staffan LU ; Strömberg, Ulf LU ; Vessby, Bengt and Jansson, Jan-Hakan (2011) In American Journal of Clinical Nutrition 93(1). p.27-36
Abstract
Background: A beneficial role of fish consumption on the risk of myocardial infarction (MI) has been reported and is mostly ascribed to n-3 (omega-3) fatty acids. However, fish also contains methylmercury, which may increase the risk of MI. Objective: The objective was to determine how fish consumption and erythrocyte concentrations of mercury (Ery-Hg) and selenium (Ery-Se) are related to the risk of MI and whether n-3 fatty acids (eicosapentaenoic and docosahexaenoic acids) in plasma phospholipids (P-EPA+DHA) are protective. Design: This was a case-control study nested within the northern Sweden cohort, in which data and samples were collected prospectively. The study included 431 cases with an MI after data and sample collection,... (More)
Background: A beneficial role of fish consumption on the risk of myocardial infarction (MI) has been reported and is mostly ascribed to n-3 (omega-3) fatty acids. However, fish also contains methylmercury, which may increase the risk of MI. Objective: The objective was to determine how fish consumption and erythrocyte concentrations of mercury (Ery-Hg) and selenium (Ery-Se) are related to the risk of MI and whether n-3 fatty acids (eicosapentaenoic and docosahexaenoic acids) in plasma phospholipids (P-EPA+DHA) are protective. Design: This was a case-control study nested within the northern Sweden cohort, in which data and samples were collected prospectively. The study included 431 cases with an MI after data and sample collection, including 81 sudden cardiac deaths (SCDs) and 499 matched controls. Another 69 female cases with controls from a breast cancer screening registry were included in sex-specific analyses. Results: Odds ratios for the third compared with the first tertile were 0.65 (95% CI: 0.46, 0.91) for Ery-Hg, 0.75 (95% CI: 0.53, 1.06) for Ery-Se, and 0.78 (95% CI: 0.54, 1.11) for P-EPA+DHA. Ery-Hg and P-EPA+DHA were intercorrelated (Spearman's R = 0.34). No association was seen for reported fish consumption. Multivariate modeling did not change these associations significantly. Sex-specific analyses showed no differences in risk associations. High concentrations of Ery-Se were associated with an increased risk of SCD. Conclusions: The biomarker results indicate a protective effect of fish consumption. No harmful effect of mercury was indicated in this low-exposed population in whom Ery-Hg and P-EPA+DHA were intercorrelated. Am J Clin Nutr 2011;93:27-36. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Clinical Nutrition
volume
93
issue
1
pages
27 - 36
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000285453500006
  • scopus:78651280016
ISSN
1938-3207
DOI
10.3945/ajcn.2010.29408
language
English
LU publication?
yes
id
d4643d24-c7ad-4665-ae1e-4597c10d12e7 (old id 1791163)
date added to LUP
2011-03-02 14:10:30
date last changed
2017-10-01 04:08:57
@article{d4643d24-c7ad-4665-ae1e-4597c10d12e7,
  abstract     = {Background: A beneficial role of fish consumption on the risk of myocardial infarction (MI) has been reported and is mostly ascribed to n-3 (omega-3) fatty acids. However, fish also contains methylmercury, which may increase the risk of MI. Objective: The objective was to determine how fish consumption and erythrocyte concentrations of mercury (Ery-Hg) and selenium (Ery-Se) are related to the risk of MI and whether n-3 fatty acids (eicosapentaenoic and docosahexaenoic acids) in plasma phospholipids (P-EPA+DHA) are protective. Design: This was a case-control study nested within the northern Sweden cohort, in which data and samples were collected prospectively. The study included 431 cases with an MI after data and sample collection, including 81 sudden cardiac deaths (SCDs) and 499 matched controls. Another 69 female cases with controls from a breast cancer screening registry were included in sex-specific analyses. Results: Odds ratios for the third compared with the first tertile were 0.65 (95% CI: 0.46, 0.91) for Ery-Hg, 0.75 (95% CI: 0.53, 1.06) for Ery-Se, and 0.78 (95% CI: 0.54, 1.11) for P-EPA+DHA. Ery-Hg and P-EPA+DHA were intercorrelated (Spearman's R = 0.34). No association was seen for reported fish consumption. Multivariate modeling did not change these associations significantly. Sex-specific analyses showed no differences in risk associations. High concentrations of Ery-Se were associated with an increased risk of SCD. Conclusions: The biomarker results indicate a protective effect of fish consumption. No harmful effect of mercury was indicated in this low-exposed population in whom Ery-Hg and P-EPA+DHA were intercorrelated. Am J Clin Nutr 2011;93:27-36.},
  author       = {Wennberg, Maria and Bergdahl, Ingvar A. and Hallmans, Goran and Norberg, Margareta and Lundh, Thomas and Skerfving, Staffan and Strömberg, Ulf and Vessby, Bengt and Jansson, Jan-Hakan},
  issn         = {1938-3207},
  language     = {eng},
  number       = {1},
  pages        = {27--36},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Fish consumption and myocardial infarction: a second prospective biomarker study from northern Sweden},
  url          = {http://dx.doi.org/10.3945/ajcn.2010.29408},
  volume       = {93},
  year         = {2011},
}