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Serotonergic Regulation of Insulin Secretion

Cataldo Bascuñan, Luis Rodrigo LU ; Lyons, Claire LU ; Bennet, Hedvig LU ; Artner, Isabella LU and Fex, Malin LU (2019) In Acta Physiologica 225(1).
Abstract

The exact physiological role for the monoamine serotonin (5-HT) in modulation of insulin secretion is yet to be fully understood. Although the presence of this monoamine in islets of Langerhans is well established, it is only with recent advances that the complex signaling network in islets involving 5-HT is being unraveled. With more than fourteen different 5-HT receptors expressed in human islets, and receptor independent mechanisms in insulin producing β-cells, our understanding of 5-HT's regulation of insulin secretion is increasing. It is now widely accepted that failure of the pancreatic β-cell to release sufficient amounts of insulin is the main cause of Type 2 Diabetes (T2D), an ongoing global epidemic. In this context, 5-HT... (More)

The exact physiological role for the monoamine serotonin (5-HT) in modulation of insulin secretion is yet to be fully understood. Although the presence of this monoamine in islets of Langerhans is well established, it is only with recent advances that the complex signaling network in islets involving 5-HT is being unraveled. With more than fourteen different 5-HT receptors expressed in human islets, and receptor independent mechanisms in insulin producing β-cells, our understanding of 5-HT's regulation of insulin secretion is increasing. It is now widely accepted that failure of the pancreatic β-cell to release sufficient amounts of insulin is the main cause of Type 2 Diabetes (T2D), an ongoing global epidemic. In this context, 5-HT signaling may be of importance. In fact, 5-HT may serve an essential role in regulating the release of insulin and glucagon, the two main hormones that control glucose and lipid homeostasis. In the present review, we will discuss past and current understanding of 5-HT's role in the endocrine pancreas. This article is protected by copyright. All rights reserved.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Physiologica
volume
225
issue
1
publisher
Wiley-Blackwell
external identifiers
  • scopus:85054304296
ISSN
1748-1708
DOI
10.1111/apha.13101
language
English
LU publication?
yes
id
17f74413-ddbe-40d5-b4f3-9ec4ac67a0dd
date added to LUP
2018-06-04 11:00:18
date last changed
2019-11-13 05:09:36
@article{17f74413-ddbe-40d5-b4f3-9ec4ac67a0dd,
  abstract     = {<p>The exact physiological role for the monoamine serotonin (5-HT) in modulation of insulin secretion is yet to be fully understood. Although the presence of this monoamine in islets of Langerhans is well established, it is only with recent advances that the complex signaling network in islets involving 5-HT is being unraveled. With more than fourteen different 5-HT receptors expressed in human islets, and receptor independent mechanisms in insulin producing β-cells, our understanding of 5-HT's regulation of insulin secretion is increasing. It is now widely accepted that failure of the pancreatic β-cell to release sufficient amounts of insulin is the main cause of Type 2 Diabetes (T2D), an ongoing global epidemic. In this context, 5-HT signaling may be of importance. In fact, 5-HT may serve an essential role in regulating the release of insulin and glucagon, the two main hormones that control glucose and lipid homeostasis. In the present review, we will discuss past and current understanding of 5-HT's role in the endocrine pancreas. This article is protected by copyright. All rights reserved.</p>},
  articleno    = {e13101},
  author       = {Cataldo Bascuñan, Luis Rodrigo and Lyons, Claire and Bennet, Hedvig and Artner, Isabella and Fex, Malin},
  issn         = {1748-1708},
  language     = {eng},
  number       = {1},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiologica},
  title        = {Serotonergic Regulation of Insulin Secretion},
  url          = {http://dx.doi.org/10.1111/apha.13101},
  volume       = {225},
  year         = {2019},
}