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Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves

Hansson, H A ; Dahlin, L B LU orcid ; Danielsen, Nils LU ; Fryklund, L ; Nachemson, A K ; Polleryd, P ; Rozell, Bjorn ; Skottner, Anna ; Stemme, S and Lundborg, G LU (1986) In Acta Physiologica Scandinavica 126(4). p.14-609
Abstract

The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating... (More)

The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Animals, Female, Fluorescent Antibody Technique, Insulin-Like Growth Factor I, Nerve Regeneration, Peripheral Nerves, Rats, Rats, Inbred Strains, Schwann Cells, Sciatic Nerve, Somatomedins, Time Factors, Journal Article, Research Support, Non-U.S. Gov't
in
Acta Physiologica Scandinavica
volume
126
issue
4
pages
6 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:3521205
  • scopus:0022452186
ISSN
0001-6772
DOI
10.1111/j.1748-1716.1986.tb07862.x
language
English
LU publication?
yes
id
186456bf-7329-4f7c-bf41-92bea3a8fd84
date added to LUP
2017-10-13 14:09:34
date last changed
2024-01-14 07:26:54
@article{186456bf-7329-4f7c-bf41-92bea3a8fd84,
  abstract     = {{<p>The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.</p>}},
  author       = {{Hansson, H A and Dahlin, L B and Danielsen, Nils and Fryklund, L and Nachemson, A K and Polleryd, P and Rozell, Bjorn and Skottner, Anna and Stemme, S and Lundborg, G}},
  issn         = {{0001-6772}},
  keywords     = {{Animals; Female; Fluorescent Antibody Technique; Insulin-Like Growth Factor I; Nerve Regeneration; Peripheral Nerves; Rats; Rats, Inbred Strains; Schwann Cells; Sciatic Nerve; Somatomedins; Time Factors; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{14--609}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Physiologica Scandinavica}},
  title        = {{Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves}},
  url          = {{http://dx.doi.org/10.1111/j.1748-1716.1986.tb07862.x}},
  doi          = {{10.1111/j.1748-1716.1986.tb07862.x}},
  volume       = {{126}},
  year         = {{1986}},
}