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Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves

Hansson, H A; Dahlin, L B LU ; Danielsen, Nils LU ; Fryklund, L; Nachemson, A K; Polleryd, P; Rozell, Bjorn; Skottner, Anna; Stemme, S and Lundborg, G LU (1986) In Acta Physiol.Scand 126(4). p.14-609
Abstract

The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating... (More)

The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.

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published
subject
keywords
Animals, Female, Fluorescent Antibody Technique, Insulin-Like Growth Factor I, Nerve Regeneration, Peripheral Nerves, Rats, Rats, Inbred Strains, Schwann Cells, Sciatic Nerve, Somatomedins, Time Factors, Journal Article, Research Support, Non-U.S. Gov't
in
Acta Physiol.Scand
volume
126
issue
4
pages
6 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:0022452186
ISSN
0001-6772
DOI
10.1111/j.1748-1716.1986.tb07862.x
language
English
LU publication?
yes
id
186456bf-7329-4f7c-bf41-92bea3a8fd84
date added to LUP
2017-10-13 14:09:34
date last changed
2017-11-13 14:10:40
@article{186456bf-7329-4f7c-bf41-92bea3a8fd84,
  abstract     = {<p>The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.</p>},
  author       = {Hansson, H A and Dahlin, L B and Danielsen, Nils and Fryklund, L and Nachemson, A K and Polleryd, P and Rozell, Bjorn and Skottner, Anna and Stemme, S and Lundborg, G},
  issn         = {0001-6772},
  keyword      = {Animals,Female,Fluorescent Antibody Technique,Insulin-Like Growth Factor I,Nerve Regeneration,Peripheral Nerves,Rats,Rats, Inbred Strains,Schwann Cells,Sciatic Nerve,Somatomedins,Time Factors,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {4},
  pages        = {14--609},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiol.Scand},
  title        = {Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves},
  url          = {http://dx.doi.org/10.1111/j.1748-1716.1986.tb07862.x},
  volume       = {126},
  year         = {1986},
}