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Seroconversion to islet autoantibodies between early pregnancy and delivery in non-diabetic mothers

Lindehammer, Sabina LU ; Jönsson, Ida LU ; Midberg, Bo LU ; Ivarsson, Sten LU ; Lynch, Kristian LU ; Dillner, Joakim LU and Lernmark, Åke LU (2011) In Journal of Reproductive Immunology 88(1). p.72-79
Abstract
Islet autoantibodies are currently used to classify type 1 diabetes at diagnosis as they reflect the autoimmune pathogenesis of the disease. The presence of maternal autoantibodies reactive with pancreatic islet antigens is thought to increase the risk for type 1 diabetes in the offspring. The objective of this study was to determine seroconversion to islet autoantibodies in non-diabetic mothers during pregnancy. Screening of 33,682 mothers between September 2000 and August 2004 in the Diabetes Prediction in Skane (DiPiS) study showed that at delivery, 242 non-diabetic mothers had increased titers of islet autoantibodies reactive with glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A) or insulin (IAA), alone or in combination.... (More)
Islet autoantibodies are currently used to classify type 1 diabetes at diagnosis as they reflect the autoimmune pathogenesis of the disease. The presence of maternal autoantibodies reactive with pancreatic islet antigens is thought to increase the risk for type 1 diabetes in the offspring. The objective of this study was to determine seroconversion to islet autoantibodies in non-diabetic mothers during pregnancy. Screening of 33,682 mothers between September 2000 and August 2004 in the Diabetes Prediction in Skane (DiPiS) study showed that at delivery, 242 non-diabetic mothers had increased titers of islet autoantibodies reactive with glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A) or insulin (IAA), alone or in combination. Control mothers (n = 1419), who were islet autoantibody negative at delivery, were randomly selected and matched by age, parity and pregnancy sampling date. Mothers positive for GADA (92%), IA-2A (84%) or IAA (65%) at delivery had increased titers already evident in early pregnancy. Titers declined for GADA (p<0.0001). IA-2A (p<0.0001) and IAA (p<0.0001). Seroconversion during pregnancy was observed for GADA in 10 (8%), IA-2A in 3 (16%) and IAA in 37 (35%) mothers. It is concluded that non-diabetic mothers with islet autoantibodies at delivery had significantly higher titers during early pregnancy than at delivery. As the statistical power in the seroconverting mothers was insufficient, further studies are needed to determine if the risk for type 1 diabetes in the offspring differs between mothers who already had increased titers of islet autoantibodies during early pregnancy or acquired them during pregnancy. (C) 2010 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autoimmunity, Pregnancy, Seroconversion, Glutamic acid decarboxylase, autoantibody, Islet antigen-2 autoantibody, Insulin autoantibody
in
Journal of Reproductive Immunology
volume
88
issue
1
pages
72 - 79
publisher
Elsevier
external identifiers
  • wos:000286540100011
  • scopus:78650228451
ISSN
1872-7603
DOI
10.1016/j.jri.2010.10.002
language
English
LU publication?
yes
id
b8509d47-4996-4e1b-ba34-8e9f748935b0 (old id 1882436)
date added to LUP
2011-04-01 08:37:51
date last changed
2017-01-01 03:48:24
@article{b8509d47-4996-4e1b-ba34-8e9f748935b0,
  abstract     = {Islet autoantibodies are currently used to classify type 1 diabetes at diagnosis as they reflect the autoimmune pathogenesis of the disease. The presence of maternal autoantibodies reactive with pancreatic islet antigens is thought to increase the risk for type 1 diabetes in the offspring. The objective of this study was to determine seroconversion to islet autoantibodies in non-diabetic mothers during pregnancy. Screening of 33,682 mothers between September 2000 and August 2004 in the Diabetes Prediction in Skane (DiPiS) study showed that at delivery, 242 non-diabetic mothers had increased titers of islet autoantibodies reactive with glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A) or insulin (IAA), alone or in combination. Control mothers (n = 1419), who were islet autoantibody negative at delivery, were randomly selected and matched by age, parity and pregnancy sampling date. Mothers positive for GADA (92%), IA-2A (84%) or IAA (65%) at delivery had increased titers already evident in early pregnancy. Titers declined for GADA (p&lt;0.0001). IA-2A (p&lt;0.0001) and IAA (p&lt;0.0001). Seroconversion during pregnancy was observed for GADA in 10 (8%), IA-2A in 3 (16%) and IAA in 37 (35%) mothers. It is concluded that non-diabetic mothers with islet autoantibodies at delivery had significantly higher titers during early pregnancy than at delivery. As the statistical power in the seroconverting mothers was insufficient, further studies are needed to determine if the risk for type 1 diabetes in the offspring differs between mothers who already had increased titers of islet autoantibodies during early pregnancy or acquired them during pregnancy. (C) 2010 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Lindehammer, Sabina and Jönsson, Ida and Midberg, Bo and Ivarsson, Sten and Lynch, Kristian and Dillner, Joakim and Lernmark, Åke},
  issn         = {1872-7603},
  keyword      = {Autoimmunity,Pregnancy,Seroconversion,Glutamic acid decarboxylase,autoantibody,Islet antigen-2 autoantibody,Insulin autoantibody},
  language     = {eng},
  number       = {1},
  pages        = {72--79},
  publisher    = {Elsevier},
  series       = {Journal of Reproductive Immunology},
  title        = {Seroconversion to islet autoantibodies between early pregnancy and delivery in non-diabetic mothers},
  url          = {http://dx.doi.org/10.1016/j.jri.2010.10.002},
  volume       = {88},
  year         = {2011},
}