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Tissue diagnostics using laser-induced fluorescence

Andersson-Engels, S. LU ; Ankerst, J. LU orcid ; Brun, A. LU ; Elner, Ar ; Gustafson, A. ; Johansson, J. ; Karlsson, S. E. ; Killander, D. LU ; Kjellen, E. LU and Lindstedt, E. , et al. (1989) Discussion Meeting of The Deutsche Bunsen-Gesellschaft fuer Physikalische Chemie In Berichte der Bunsengesellschaft für Physikalische Chemie 93(3). p.335-342
Abstract

We have performed extensive investigations of laser-induced fluorescence in animal and human tissue aimed at instant tissue characterization. Autofluorescence, as well as specific fluorescence from HPD/DHE and other photosensitizers, has been utilized. The studies have been focused on the demarcation of malignant tumours and atheroscleortic plaques. A nitrogen laser or an excimer-pumped dye laser was used to induce fluorescence, which was analysed with an intensified optical multichannel system. A fibre-optic sensor system was developed for the clinical work. Multi-colour fluorescence imaging has also been demonstrated along a line and equipment for two-dimensional imaging is being constructed. Dimensionless spectroscopic functions,... (More)

We have performed extensive investigations of laser-induced fluorescence in animal and human tissue aimed at instant tissue characterization. Autofluorescence, as well as specific fluorescence from HPD/DHE and other photosensitizers, has been utilized. The studies have been focused on the demarcation of malignant tumours and atheroscleortic plaques. A nitrogen laser or an excimer-pumped dye laser was used to induce fluorescence, which was analysed with an intensified optical multichannel system. A fibre-optic sensor system was developed for the clinical work. Multi-colour fluorescence imaging has also been demonstrated along a line and equipment for two-dimensional imaging is being constructed. Dimensionless spectroscopic functions, which are not affected by factors that are clinically uncontrollable have been employed for optimum tissue discrimination. The investigations have so far been performed in a time-integrated mode, but time-resolved studies are now being initiated to fully exploit the diagnostic power of tissue laser-induced fluorescence. In addition to a presentation of our own work a brief review of tissue fluorescence studies performed by other groups is also given.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Berichte der Bunsengesellschaft für Physikalische Chemie
volume
93
issue
3
pages
335 - 342
publisher
VCH Publishers
conference name
Discussion Meeting of The Deutsche Bunsen-Gesellschaft fuer Physikalische Chemie
conference location
Heildelberg, West Ger
conference dates
1988-08-29 - 1988-09-01
external identifiers
  • scopus:0024629190
ISSN
0005-9021
DOI
10.1002/bbpc.19890930323
language
English
LU publication?
yes
id
1926c223-ca1d-4764-9419-e55663527b01
date added to LUP
2021-12-23 10:34:30
date last changed
2024-02-05 07:29:37
@article{1926c223-ca1d-4764-9419-e55663527b01,
  abstract     = {{<p>We have performed extensive investigations of laser-induced fluorescence in animal and human tissue aimed at instant tissue characterization. Autofluorescence, as well as specific fluorescence from HPD/DHE and other photosensitizers, has been utilized. The studies have been focused on the demarcation of malignant tumours and atheroscleortic plaques. A nitrogen laser or an excimer-pumped dye laser was used to induce fluorescence, which was analysed with an intensified optical multichannel system. A fibre-optic sensor system was developed for the clinical work. Multi-colour fluorescence imaging has also been demonstrated along a line and equipment for two-dimensional imaging is being constructed. Dimensionless spectroscopic functions, which are not affected by factors that are clinically uncontrollable have been employed for optimum tissue discrimination. The investigations have so far been performed in a time-integrated mode, but time-resolved studies are now being initiated to fully exploit the diagnostic power of tissue laser-induced fluorescence. In addition to a presentation of our own work a brief review of tissue fluorescence studies performed by other groups is also given.</p>}},
  author       = {{Andersson-Engels, S. and Ankerst, J. and Brun, A. and Elner, Ar and Gustafson, A. and Johansson, J. and Karlsson, S. E. and Killander, D. and Kjellen, E. and Lindstedt, E. and Montán, S. and Salford, L. G. and Simonsson, B. and Stenram, U. and Stromblad, L. G. and Svanberg, K. and Svanberg, S}},
  issn         = {{0005-9021}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{335--342}},
  publisher    = {{VCH Publishers}},
  series       = {{Berichte der Bunsengesellschaft für Physikalische Chemie}},
  title        = {{Tissue diagnostics using laser-induced fluorescence}},
  url          = {{http://dx.doi.org/10.1002/bbpc.19890930323}},
  doi          = {{10.1002/bbpc.19890930323}},
  volume       = {{93}},
  year         = {{1989}},
}