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Immunohistochemistry in the differential diagnostics of primary lung cancer: an investigation within the southern Swedish lung cancer study.

Brunnström, Hans LU ; Johansson, Leif LU ; Jirström, Karin LU ; Jönsson, Mats LU ; Jönsson, Per LU and Planck, Maria LU (2013) In American Journal of Clinical Pathology 140(1). p.37-46
Abstract
Objectives: To assess immunohistochemical (IHC) stains differentially expressed between different types of lung cancer. Methods: We evaluated 16 different IHC stains in 209 prospectively included, surgically treated primary lung cancers, including 121 adenocarcinomas, 65 squamous cell carcinomas, 15 large-cell carcinomas, 5 adenosquamous carcinomas, 2 sarcomatoid carcinomas, and 1 small-cell carcinoma, using the tissue microarray technique. Results: Cytokeratin 5 (CK5) and P63 were both positive in 10% or more of the cells in 97% of the squamous cell carcinomas, with the former being positive (<10% of the cells) in only 2 non-squamous cell carcinomas. Thyroid transcription factor 1 (TTF1) and napsin A were positive in 10% or more of the... (More)
Objectives: To assess immunohistochemical (IHC) stains differentially expressed between different types of lung cancer. Methods: We evaluated 16 different IHC stains in 209 prospectively included, surgically treated primary lung cancers, including 121 adenocarcinomas, 65 squamous cell carcinomas, 15 large-cell carcinomas, 5 adenosquamous carcinomas, 2 sarcomatoid carcinomas, and 1 small-cell carcinoma, using the tissue microarray technique. Results: Cytokeratin 5 (CK5) and P63 were both positive in 10% or more of the cells in 97% of the squamous cell carcinomas, with the former being positive (<10% of the cells) in only 2 non-squamous cell carcinomas. Thyroid transcription factor 1 (TTF1) and napsin A were positive in 10% or more of the cells in 88% and 87% of the adenocarcinomas, respectively, with 94% of the adenocarcinomas being positive in at least 1 marker. Fifteen percent of the adenocarcinomas were positive for estrogen receptor. Conclusions: CK5, TTF1, and napsin A are sensitive markers for squamous cell carcinoma and adenocarcinoma of the lung. (Less)
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type
Contribution to journal
publication status
published
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in
American Journal of Clinical Pathology
volume
140
issue
1
pages
37 - 46
publisher
American Society for Clinical Pathology
external identifiers
  • wos:000320634100004
  • pmid:23765532
  • scopus:84879423454
ISSN
1943-7722
DOI
10.1309/AJCP50RDXSCSBTBO
language
English
LU publication?
yes
id
19b84a19-e420-4bbe-8438-9d864a444fcf (old id 3913386)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23765532?dopt=Abstract
date added to LUP
2013-07-01 12:54:00
date last changed
2019-03-19 01:16:28
@article{19b84a19-e420-4bbe-8438-9d864a444fcf,
  abstract     = {Objectives: To assess immunohistochemical (IHC) stains differentially expressed between different types of lung cancer. Methods: We evaluated 16 different IHC stains in 209 prospectively included, surgically treated primary lung cancers, including 121 adenocarcinomas, 65 squamous cell carcinomas, 15 large-cell carcinomas, 5 adenosquamous carcinomas, 2 sarcomatoid carcinomas, and 1 small-cell carcinoma, using the tissue microarray technique. Results: Cytokeratin 5 (CK5) and P63 were both positive in 10% or more of the cells in 97% of the squamous cell carcinomas, with the former being positive (&lt;10% of the cells) in only 2 non-squamous cell carcinomas. Thyroid transcription factor 1 (TTF1) and napsin A were positive in 10% or more of the cells in 88% and 87% of the adenocarcinomas, respectively, with 94% of the adenocarcinomas being positive in at least 1 marker. Fifteen percent of the adenocarcinomas were positive for estrogen receptor. Conclusions: CK5, TTF1, and napsin A are sensitive markers for squamous cell carcinoma and adenocarcinoma of the lung.},
  author       = {Brunnström, Hans and Johansson, Leif and Jirström, Karin and Jönsson, Mats and Jönsson, Per and Planck, Maria},
  issn         = {1943-7722},
  language     = {eng},
  number       = {1},
  pages        = {37--46},
  publisher    = {American Society for Clinical Pathology},
  series       = {American Journal of Clinical Pathology},
  title        = {Immunohistochemistry in the differential diagnostics of primary lung cancer: an investigation within the southern Swedish lung cancer study.},
  url          = {http://dx.doi.org/10.1309/AJCP50RDXSCSBTBO},
  volume       = {140},
  year         = {2013},
}