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Plasma Phospholipid Long-Chain n-3 Polyunsaturated Fatty Acids and Body Weight Change

Jakobsen, Marianne U.; Dethlefsen, Claus; Due, Karen M.; Slimani, Nadia; Chajes, Veronique; May, Anne M.; Sorensen, Thorkild I. A.; Halkjaer, Jytte; Tjonneland, Anne and Clavel-Chapelon, Francoise, et al. (2011) In Obesity Facts 4(4). p.312-318
Abstract
Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight... (More)
Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population. (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
Body weight, Cohort study, n-3 fatty acids, Omega-3 fatty acids, Weight, change
in
Obesity Facts
volume
4
issue
4
pages
312 - 318
publisher
Karger
external identifiers
  • wos:000294763300009
  • scopus:80053027100
ISSN
1662-4033
DOI
10.1159/000330710
language
English
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yes
id
e6fc6fc6-8874-4ba0-b568-5857c4007c8c (old id 2186714)
date added to LUP
2011-11-01 07:51:16
date last changed
2017-01-01 03:00:38
@article{e6fc6fc6-8874-4ba0-b568-5857c4007c8c,
  abstract     = {Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.},
  author       = {Jakobsen, Marianne U. and Dethlefsen, Claus and Due, Karen M. and Slimani, Nadia and Chajes, Veronique and May, Anne M. and Sorensen, Thorkild I. A. and Halkjaer, Jytte and Tjonneland, Anne and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Fagherazzi, Guy and Teucher, Birgit and Kaaks, Rudolf and Boeing, Heiner and Schuetze, Madlen and Trichopoulou, Antonia and Zylis, Dimosthenis and Makrygiannis, George and Palli, Domenico and Mattiello, Amalia and Tagliabue, Giovanna and van der A, Daphne L. and Bueno-de-Mesquita, H. B. and Rodriguez, Laudina and Travier, Noemie and Molina-Montes, Esther and Huerta, Jose M. and Barricarte, Aurelio and Amiano, Pilar and Manjer, Jonas and Wirfält, Elisabet and Johansson, Ingegerd and Hallmans, Goran and Khaw, Kay-Tee and Wareham, Nicholas J. and Crowe, Francesca and Romieu, Isabelle and Riboli, Elio and Peeters, Petra H. M. and Overvad, Kim},
  issn         = {1662-4033},
  keyword      = {Body weight,Cohort study,n-3 fatty acids,Omega-3 fatty acids,Weight,change},
  language     = {eng},
  number       = {4},
  pages        = {312--318},
  publisher    = {Karger},
  series       = {Obesity Facts},
  title        = {Plasma Phospholipid Long-Chain n-3 Polyunsaturated Fatty Acids and Body Weight Change},
  url          = {http://dx.doi.org/10.1159/000330710},
  volume       = {4},
  year         = {2011},
}