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Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments.

Håkansson, Åsa; Bränning, Camilla; Molin, Göran; Adawi, Diya LU ; Hagslätt, Marie-Louise; Nyman, Margareta; Jeppsson, Bengt LU and Ahrné, Siv (2011) In Gastroenterology Research and Practice 2011.
Abstract
Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count of Enterobacteriaceae. The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and... (More)
Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count of Enterobacteriaceae. The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and lower proportions of butyrate in colonic content were found. The DSS model seems to mimic the clinical situation and may be valuable for investigation of inflammation-related dysplasia and colon cancer, as well as for altered liver function by endogenous inflammatory mediators. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Gastroenterology Research and Practice
volume
2011
publisher
Hindawi Publishing Corporation
external identifiers
  • wos:000298432600001
  • pmid:22007198
  • scopus:84855268709
ISSN
1687-630X
DOI
10.1155/2011/924045
language
English
LU publication?
yes
id
14fe07c8-b731-46eb-a8c4-c5c9978a60cf (old id 2200421)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22007198?dopt=Abstract
date added to LUP
2011-11-02 10:37:57
date last changed
2017-01-01 03:31:05
@article{14fe07c8-b731-46eb-a8c4-c5c9978a60cf,
  abstract     = {Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count of Enterobacteriaceae. The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and lower proportions of butyrate in colonic content were found. The DSS model seems to mimic the clinical situation and may be valuable for investigation of inflammation-related dysplasia and colon cancer, as well as for altered liver function by endogenous inflammatory mediators.},
  articleno    = {924045},
  author       = {Håkansson, Åsa and Bränning, Camilla and Molin, Göran and Adawi, Diya and Hagslätt, Marie-Louise and Nyman, Margareta and Jeppsson, Bengt and Ahrné, Siv},
  issn         = {1687-630X},
  language     = {eng},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Gastroenterology Research and Practice},
  title        = {Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments.},
  url          = {http://dx.doi.org/10.1155/2011/924045},
  volume       = {2011},
  year         = {2011},
}