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Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity

Axling, Ulrika LU ; Dey, Estera LU ; Holm, Cecilia LU and Degerman, Eva LU (2011) In Molecular Nutrition and Food Research 55. p.290-293
Abstract
The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for stimulated lipolysis, and phosphorylation of protein kinase A substrates, were diminished after preincubation with ARs, whereas HSL protein expression was unaltered. ARs were also shown to inhibit HSL activity in an in vitro assay.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adipose tissue, Alkylresorcinols, Lipolysis, Type 2 diabetes, Whole, grain
in
Molecular Nutrition and Food Research
volume
55
pages
290 - 293
publisher
John Wiley & Sons
external identifiers
  • wos:000303246700014
  • scopus:80053269621
ISSN
1613-4133
DOI
10.1002/mnfr.201100231
language
English
LU publication?
yes
id
e4238658-5601-4280-9c8c-6e4b7f2c710b (old id 2594765)
date added to LUP
2012-06-01 09:39:31
date last changed
2017-10-01 03:18:52
@article{e4238658-5601-4280-9c8c-6e4b7f2c710b,
  abstract     = {The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for stimulated lipolysis, and phosphorylation of protein kinase A substrates, were diminished after preincubation with ARs, whereas HSL protein expression was unaltered. ARs were also shown to inhibit HSL activity in an in vitro assay.},
  author       = {Axling, Ulrika and Dey, Estera and Holm, Cecilia and Degerman, Eva},
  issn         = {1613-4133},
  keyword      = {Adipose tissue,Alkylresorcinols,Lipolysis,Type 2 diabetes,Whole,grain},
  language     = {eng},
  pages        = {290--293},
  publisher    = {John Wiley & Sons},
  series       = {Molecular Nutrition and Food Research},
  title        = {Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity},
  url          = {http://dx.doi.org/10.1002/mnfr.201100231},
  volume       = {55},
  year         = {2011},
}