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Short-term association between outdoor temperature and the hydration-marker copeptin : a pooled analysis in five cohorts

Timpka, Simon LU orcid ; Melander, Olle LU orcid ; Engström, Gunnar LU ; Elmståhl, Sölve LU ; Nilsson, Peter M LU ; Lind, Lars ; Pihlsgård, Mats LU and Enhörning, Sofia LU (2023) In EBioMedicine 95.
Abstract

BACKGROUND: Whereas outdoor temperature is linked to both mortality and hydration status, the hormone vasopressin, measured through the surrogate copeptin, is a marker of cardiometabolic risk and hydration. We recently showed that copeptin has a seasonal pattern with higher plasma concentration in winter. Here, we aimed to investigate the association between outdoor temperature and copeptin.

METHODS: Copeptin was analysed in fasting plasma from five cohorts in Malmö, Sweden (n = 26,753, 49.7% men, age 18-86 years). We utilized a multivariable adjusted non-linear spline model with four knots to investigate the association between short-term temperature (24 h mean apparent) and log copeptin z-score.

FINDINGS: We found a... (More)

BACKGROUND: Whereas outdoor temperature is linked to both mortality and hydration status, the hormone vasopressin, measured through the surrogate copeptin, is a marker of cardiometabolic risk and hydration. We recently showed that copeptin has a seasonal pattern with higher plasma concentration in winter. Here, we aimed to investigate the association between outdoor temperature and copeptin.

METHODS: Copeptin was analysed in fasting plasma from five cohorts in Malmö, Sweden (n = 26,753, 49.7% men, age 18-86 years). We utilized a multivariable adjusted non-linear spline model with four knots to investigate the association between short-term temperature (24 h mean apparent) and log copeptin z-score.

FINDINGS: We found a distinct non-linear association between temperature and log copeptin z-score, with both moderately low and high temperatures linked to higher copeptin concentration (p < 0.0001). Between 0 °C and nadir at the 75th temperature percentile (corresponding to 14.3 °C), log copeptin decreased 0.13 z-scores (95% CI 0.096; 0.16), which also inversely corresponded to the increase in z-score log copeptin between the nadir and 21.3 °C.

INTERPRETATION: The J-shaped association between short-term temperature and copeptin resembles the J-shaped association between temperature and mortality. Whereas the untangling of temperature from other seasonal effects on hydration warrants further study, moderately increased water intake constitutes a feasible intervention to lower vasopressin and might mitigate adverse health effects of both moderately cold and hot outdoor temperatures.

FUNDING: Swedish Research Council, Å Wiberg, M Stephen, A Påhlsson, Crafoord and Swedish Heart-Lung Foundations, Swedish Society for Medical Research and Swedish Society of Medicine.

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; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Young Adult, Biomarkers/blood, Glycopeptides/blood, Temperature, Vasopressins/blood, Seasons, Hot Temperature, Cold Temperature
in
EBioMedicine
volume
95
article number
104750
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:85166928927
  • pmid:37556945
ISSN
2352-3964
DOI
10.1016/j.ebiom.2023.104750
language
English
LU publication?
yes
additional info
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
id
2f6ede7b-49b9-40d0-9b73-06b527a81819
date added to LUP
2023-10-10 12:36:15
date last changed
2024-04-19 02:11:33
@article{2f6ede7b-49b9-40d0-9b73-06b527a81819,
  abstract     = {{<p>BACKGROUND: Whereas outdoor temperature is linked to both mortality and hydration status, the hormone vasopressin, measured through the surrogate copeptin, is a marker of cardiometabolic risk and hydration. We recently showed that copeptin has a seasonal pattern with higher plasma concentration in winter. Here, we aimed to investigate the association between outdoor temperature and copeptin.</p><p>METHODS: Copeptin was analysed in fasting plasma from five cohorts in Malmö, Sweden (n = 26,753, 49.7% men, age 18-86 years). We utilized a multivariable adjusted non-linear spline model with four knots to investigate the association between short-term temperature (24 h mean apparent) and log copeptin z-score.</p><p>FINDINGS: We found a distinct non-linear association between temperature and log copeptin z-score, with both moderately low and high temperatures linked to higher copeptin concentration (p &lt; 0.0001). Between 0 °C and nadir at the 75th temperature percentile (corresponding to 14.3 °C), log copeptin decreased 0.13 z-scores (95% CI 0.096; 0.16), which also inversely corresponded to the increase in z-score log copeptin between the nadir and 21.3 °C.</p><p>INTERPRETATION: The J-shaped association between short-term temperature and copeptin resembles the J-shaped association between temperature and mortality. Whereas the untangling of temperature from other seasonal effects on hydration warrants further study, moderately increased water intake constitutes a feasible intervention to lower vasopressin and might mitigate adverse health effects of both moderately cold and hot outdoor temperatures.</p><p>FUNDING: Swedish Research Council, Å Wiberg, M Stephen, A Påhlsson, Crafoord and Swedish Heart-Lung Foundations, Swedish Society for Medical Research and Swedish Society of Medicine.</p>}},
  author       = {{Timpka, Simon and Melander, Olle and Engström, Gunnar and Elmståhl, Sölve and Nilsson, Peter M and Lind, Lars and Pihlsgård, Mats and Enhörning, Sofia}},
  issn         = {{2352-3964}},
  keywords     = {{Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Young Adult; Biomarkers/blood; Glycopeptides/blood; Temperature; Vasopressins/blood; Seasons; Hot Temperature; Cold Temperature}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{EBioMedicine}},
  title        = {{Short-term association between outdoor temperature and the hydration-marker copeptin : a pooled analysis in five cohorts}},
  url          = {{http://dx.doi.org/10.1016/j.ebiom.2023.104750}},
  doi          = {{10.1016/j.ebiom.2023.104750}},
  volume       = {{95}},
  year         = {{2023}},
}