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Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis

Cooper, A. J.; Forouhi, N. G.; Ye, Z.; Buijsse, B.; Arriola, L.; Balkau, B.; Barricarte, A.; Beulens, J. W. J.; Boeing, H. and Buchner, F. L., et al. (2012) In European Journal of Clinical Nutrition 66(10). p.1082-1092
Abstract
Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case-cohort study nested within eight European countries, a representative sample of 16 154 participants and 12 403 incident cases of T2D were identified from 340 234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary... (More)
Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case-cohort study nested within eight European countries, a representative sample of 16 154 participants and 12 403 incident cases of T2D were identified from 340 234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary questionnaires varied more than twofold between countries. In adjusted analyses the hazard ratio (95% confidence interval) comparing the highest with lowest quartile of reported intake was 0.90 (0.80-1.01) for FVI; 0.89 (0.76-1.04) for fruit and 0.94 (0.84-1.05) for vegetables. Among FV subtypes, only root vegetables were inversely associated with diabetes 0.87 (0.77-0.99). In meta-analysis using pooled data from five studies including EPIC-InterAct, comparing the highest with lowest category for FVI was associated with a lower relative risk of diabetes (0.93 (0.87-1.00)). Fruit or vegetables separately were not associated with diabetes. Among FV subtypes, only green leafy vegetable (GLV) intake (relative risk: 0.84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect. (Less)
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keywords
fruit, vegetables, type 2 diabetes mellitus, epidemiology, meta-analysis, review
in
European Journal of Clinical Nutrition
volume
66
issue
10
pages
1082 - 1092
publisher
Nature Publishing Group
external identifiers
  • wos:000309646100003
  • scopus:84867100232
ISSN
1476-5640
DOI
10.1038/ejcn.2012.85
language
English
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ba57e4f4-c435-43cb-8a81-50b453230145 (old id 3174932)
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2012-12-03 06:53:45
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@article{ba57e4f4-c435-43cb-8a81-50b453230145,
  abstract     = {Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case-cohort study nested within eight European countries, a representative sample of 16 154 participants and 12 403 incident cases of T2D were identified from 340 234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary questionnaires varied more than twofold between countries. In adjusted analyses the hazard ratio (95% confidence interval) comparing the highest with lowest quartile of reported intake was 0.90 (0.80-1.01) for FVI; 0.89 (0.76-1.04) for fruit and 0.94 (0.84-1.05) for vegetables. Among FV subtypes, only root vegetables were inversely associated with diabetes 0.87 (0.77-0.99). In meta-analysis using pooled data from five studies including EPIC-InterAct, comparing the highest with lowest category for FVI was associated with a lower relative risk of diabetes (0.93 (0.87-1.00)). Fruit or vegetables separately were not associated with diabetes. Among FV subtypes, only green leafy vegetable (GLV) intake (relative risk: 0.84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect.},
  author       = {Cooper, A. J. and Forouhi, N. G. and Ye, Z. and Buijsse, B. and Arriola, L. and Balkau, B. and Barricarte, A. and Beulens, J. W. J. and Boeing, H. and Buchner, F. L. and Dahm, C. C. and de Lauzon-Guillain, B. and Fagherazzi, G. and Franks, Paul and Gonzalez, C. and Grioni, S. and Kaaks, R. and Key, T. J. and Masala, G. and Navarro, C. and Nilsson, P. and Overvad, K. and Panico, S. and Ramon Quiros, J. and Rolandsson, O. and Roswall, N. and Sacerdote, C. and Sanchez, M-J and Slimani, N. and Sluijs, I. and Spijkerman, A. M. W. and Teucher, B. and Tjonneland, A. and Tumino, R. and Sharp, S. J. and Langenberg, C. and Feskens, E. J. M. and Riboli, E. and Wareham, N. J.},
  issn         = {1476-5640},
  keyword      = {fruit,vegetables,type 2 diabetes mellitus,epidemiology,meta-analysis,review},
  language     = {eng},
  number       = {10},
  pages        = {1082--1092},
  publisher    = {Nature Publishing Group},
  series       = {European Journal of Clinical Nutrition},
  title        = {Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis},
  url          = {http://dx.doi.org/10.1038/ejcn.2012.85},
  volume       = {66},
  year         = {2012},
}