Added sugar intake and its forms and sources in relation to risk of non-alcoholic fatty liver disease : results from the Tianjin Chronic Low-grade Systemic Inflammation and Health cohort study
(2023) In British Journal of Nutrition 129(12). p.2094-2101- Abstract
It has been suggested that added sugar intake is associated with non-alcoholic fatty liver disease (NAFLD). However, previous studies only focused on sugar-sweetened beverages; the evidence for associations with total added sugars and their sources is scarce. This study aimed to examine the associations of total added sugars, their physical forms (liquid vs. solid), and food sources with risk of NAFLD among adults in Tianjin, China. We used data from 15,538 participants, free of NAFLD, other liver diseases, cardiovascular disease, cancer, or diabetes at baseline (2013-2018 years). Added sugar intake was estimated from a validated 100-item food frequency questionnaire. NAFLD was diagnosed by ultrasonography after exclusion of other... (More)
It has been suggested that added sugar intake is associated with non-alcoholic fatty liver disease (NAFLD). However, previous studies only focused on sugar-sweetened beverages; the evidence for associations with total added sugars and their sources is scarce. This study aimed to examine the associations of total added sugars, their physical forms (liquid vs. solid), and food sources with risk of NAFLD among adults in Tianjin, China. We used data from 15,538 participants, free of NAFLD, other liver diseases, cardiovascular disease, cancer, or diabetes at baseline (2013-2018 years). Added sugar intake was estimated from a validated 100-item food frequency questionnaire. NAFLD was diagnosed by ultrasonography after exclusion of other causes of liver diseases. Multivariable Cox proportional hazards models were fitted to calculate hazards ratios (HRs) and corresponding 95% confidence intervals (CIs) for NAFLD risk with added sugar intake. During a median follow-up of 4.2 years, 3,476 incident NAFLD cases were documented. After adjusting for age, sex, body mass index and its change from baseline to follow-up, lifestyle factors, personal and family medical history, and overall diet quality, the multivariable HRs (95% CIs) of NAFLD risk were 1.18 (1.06, 1.32) for total added sugars, 1.20 (1.08, 1.33) for liquid added sugars, and 0.96 (0.86, 1.07) for solid added sugars when comparing the highest quartiles of intake with the lowest quartiles of intake. In this prospective cohort of Chinese adults, higher intakes of total added sugars and liquid added sugars, but not solid added sugars, were associated with a higher risk of NAFLD.
(Less)
- author
- Zhang, Shunming
LU
; Li, Huiping
LU
; Meng, Ge
; Zhang, Qing
; Liu, Li
; Wu, Hongmei
; Gu, Yeqing
; Zhang, Tingjing
; Wang, Xuena
; Zhang, Juanjuan
; Dong, Jun
; Zheng, Xiaoxi
; Cao, Zhixia
; Zhang, Xu
; Dong, Xinrong
; Sun, Shaomei
; Wang, Xing
; Zhou, Ming
; Jia, Qiyu
; Song, Kun
; Borné, Yan
LU
; Sonestedt, Emily
LU
; Qi, Lu
and Niu, Kaijun
(Less) - author collaboration
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Nutrition
- volume
- 129
- issue
- 12
- pages
- 2094 - 2101
- publisher
- Cambridge University Press
- external identifiers
-
- pmid:36156191
- scopus:85160908027
- ISSN
- 1475-2662
- DOI
- 10.1017/S000711452200277X
- language
- English
- LU publication?
- yes
- id
- 325bf9f4-6d57-4cdf-910d-271dd3c90532
- date added to LUP
- 2022-09-30 13:24:47
- date last changed
- 2024-06-15 01:01:23
@article{325bf9f4-6d57-4cdf-910d-271dd3c90532,
abstract = {{<p>It has been suggested that added sugar intake is associated with non-alcoholic fatty liver disease (NAFLD). However, previous studies only focused on sugar-sweetened beverages; the evidence for associations with total added sugars and their sources is scarce. This study aimed to examine the associations of total added sugars, their physical forms (liquid vs. solid), and food sources with risk of NAFLD among adults in Tianjin, China. We used data from 15,538 participants, free of NAFLD, other liver diseases, cardiovascular disease, cancer, or diabetes at baseline (2013-2018 years). Added sugar intake was estimated from a validated 100-item food frequency questionnaire. NAFLD was diagnosed by ultrasonography after exclusion of other causes of liver diseases. Multivariable Cox proportional hazards models were fitted to calculate hazards ratios (HRs) and corresponding 95% confidence intervals (CIs) for NAFLD risk with added sugar intake. During a median follow-up of 4.2 years, 3,476 incident NAFLD cases were documented. After adjusting for age, sex, body mass index and its change from baseline to follow-up, lifestyle factors, personal and family medical history, and overall diet quality, the multivariable HRs (95% CIs) of NAFLD risk were 1.18 (1.06, 1.32) for total added sugars, 1.20 (1.08, 1.33) for liquid added sugars, and 0.96 (0.86, 1.07) for solid added sugars when comparing the highest quartiles of intake with the lowest quartiles of intake. In this prospective cohort of Chinese adults, higher intakes of total added sugars and liquid added sugars, but not solid added sugars, were associated with a higher risk of NAFLD.</p>}},
author = {{Zhang, Shunming and Li, Huiping and Meng, Ge and Zhang, Qing and Liu, Li and Wu, Hongmei and Gu, Yeqing and Zhang, Tingjing and Wang, Xuena and Zhang, Juanjuan and Dong, Jun and Zheng, Xiaoxi and Cao, Zhixia and Zhang, Xu and Dong, Xinrong and Sun, Shaomei and Wang, Xing and Zhou, Ming and Jia, Qiyu and Song, Kun and Borné, Yan and Sonestedt, Emily and Qi, Lu and Niu, Kaijun}},
issn = {{1475-2662}},
language = {{eng}},
number = {{12}},
pages = {{2094--2101}},
publisher = {{Cambridge University Press}},
series = {{British Journal of Nutrition}},
title = {{Added sugar intake and its forms and sources in relation to risk of non-alcoholic fatty liver disease : results from the Tianjin Chronic Low-grade Systemic Inflammation and Health cohort study}},
url = {{http://dx.doi.org/10.1017/S000711452200277X}},
doi = {{10.1017/S000711452200277X}},
volume = {{129}},
year = {{2023}},
}