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Thylakoids Promote Satiety in Healthy Humans. Metabolic Effects and Mechanisms

Erlanson-Albertsson, Charlotte LU ; Albertsson, Per-Åke LU ; Östbring, Karolina LU ; Montelius, Caroline LU ; Emek, Sinan Cem LU ; Köhnke, Rickard LU and Landin-Olsson, Mona LU (2012) Symposium on Agricultural and Food Derived Natural Products for Preventing and Combating Disease In ACS Symposium Series 1093. p.521-531
Abstract
Thylakoids are the photosynthetic membranes of the chloroplasts in green leaves. Thylakoids have been found to promote satiety when added to food, both in animal experimental models and in human. The thylakoids act through inhibition of lipase-colipase catalysed hydrolysis of triacylglycerol, which is the main dietary fat component. The mechanism for inhibition is either a binding of thylakoids to lipase-colipase, which thereby prevents to act as a lipolytic enzyme complex or binding of thylakoids to the triacylglycerol droplet, thereby hindering the access of lipase-colipase to its substrate. Thylakoids consist of proteins and lipids in a membrane structure containing various protein-bound pigments. The thylakoid membranes are fairly... (More)
Thylakoids are the photosynthetic membranes of the chloroplasts in green leaves. Thylakoids have been found to promote satiety when added to food, both in animal experimental models and in human. The thylakoids act through inhibition of lipase-colipase catalysed hydrolysis of triacylglycerol, which is the main dietary fat component. The mechanism for inhibition is either a binding of thylakoids to lipase-colipase, which thereby prevents to act as a lipolytic enzyme complex or binding of thylakoids to the triacylglycerol droplet, thereby hindering the access of lipase-colipase to its substrate. Thylakoids consist of proteins and lipids in a membrane structure containing various protein-bound pigments. The thylakoid membranes are fairly resistant to gastrointestinal breakdown, which may be an important property to explain the satiety promoting effect. Satiety is promoted through the release of cholecystokinin, a gastrointestinal hormone that causes an inhibition of gastric emptying and stimulation of satiety mechanism in the brain. The hunger hormone ghrelin is suppressed as well as insulin. In human short-term experiments thylakoids added to food promote satiety signalling. In long-term a reduced body fat mass was observed. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Food intake, insulin, ghrelin, leptin, abdominal fat, body fat, CCK, blood lipids, blood glucose
in
ACS Symposium Series
volume
1093
pages
521 - 531
publisher
The American Chemical Society
conference name
Symposium on Agricultural and Food Derived Natural Products for Preventing and Combating Disease
external identifiers
  • wos:000313024100029
  • scopus:84905666176
ISSN
0097-6156
language
English
LU publication?
yes
id
8b4d5873-9f66-4715-9c03-564dbd5b5fa3 (old id 3504139)
date added to LUP
2013-02-21 13:48:00
date last changed
2017-01-01 06:09:49
@inproceedings{8b4d5873-9f66-4715-9c03-564dbd5b5fa3,
  abstract     = {Thylakoids are the photosynthetic membranes of the chloroplasts in green leaves. Thylakoids have been found to promote satiety when added to food, both in animal experimental models and in human. The thylakoids act through inhibition of lipase-colipase catalysed hydrolysis of triacylglycerol, which is the main dietary fat component. The mechanism for inhibition is either a binding of thylakoids to lipase-colipase, which thereby prevents to act as a lipolytic enzyme complex or binding of thylakoids to the triacylglycerol droplet, thereby hindering the access of lipase-colipase to its substrate. Thylakoids consist of proteins and lipids in a membrane structure containing various protein-bound pigments. The thylakoid membranes are fairly resistant to gastrointestinal breakdown, which may be an important property to explain the satiety promoting effect. Satiety is promoted through the release of cholecystokinin, a gastrointestinal hormone that causes an inhibition of gastric emptying and stimulation of satiety mechanism in the brain. The hunger hormone ghrelin is suppressed as well as insulin. In human short-term experiments thylakoids added to food promote satiety signalling. In long-term a reduced body fat mass was observed.},
  author       = {Erlanson-Albertsson, Charlotte and Albertsson, Per-Åke and Östbring, Karolina and Montelius, Caroline and Emek, Sinan Cem and Köhnke, Rickard and Landin-Olsson, Mona},
  booktitle    = {ACS Symposium Series},
  issn         = {0097-6156},
  keyword      = {Food intake,insulin,ghrelin,leptin,abdominal fat,body fat,CCK,blood lipids,blood glucose},
  language     = {eng},
  pages        = {521--531},
  publisher    = {The American Chemical Society},
  title        = {Thylakoids Promote Satiety in Healthy Humans. Metabolic Effects and Mechanisms},
  volume       = {1093},
  year         = {2012},
}