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G protein-coupled estrogen receptor is apoptotic and correlates with increased distant disease-free survival of estrogen receptor-positive breast cancer patients.

Broselid, Stefan LU ; Cheng, Benxu; Sjöström, Martin LU ; Lövgren, Kristina LU ; Klug-De Santiago, Heather L P; Belting, Mattias LU ; Jirström, Karin LU ; Malmström, Per LU ; Olde, Björn LU and Bendahl, Pär-Ola LU , et al. (2013) In Clinical Cancer Research 19(7). p.1681-1692
Abstract
G protein-coupled estrogen receptor 1 (GPER1), previously named GPR30, is a membrane receptor reported to mediate nongenomic estrogen responses. We investigated if GPER1 expression correlates with any clinicopathologic variables and distant disease-free survival (DDFS) in patients with breast cancer, if any prognostic impact of the receptor is dependent on estrogen receptor-α (ER-α) status, and if the receptor impacts apoptotic signaling in ER-positive breast cancer cells.
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type
Contribution to journal
publication status
published
subject
in
Clinical Cancer Research
volume
19
issue
7
pages
1681 - 1692
publisher
American Association for Cancer Research
external identifiers
  • wos:000316996900008
  • pmid:23554355
  • scopus:84877088406
ISSN
1078-0432
DOI
10.1158/1078-0432.CCR-12-2376
language
English
LU publication?
yes
id
0c5895c1-f055-46d6-8583-248b37d9ace7 (old id 3734200)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23554355?dopt=Abstract
date added to LUP
2013-05-02 12:33:01
date last changed
2019-03-27 01:23:27
@article{0c5895c1-f055-46d6-8583-248b37d9ace7,
  abstract     = {G protein-coupled estrogen receptor 1 (GPER1), previously named GPR30, is a membrane receptor reported to mediate nongenomic estrogen responses. We investigated if GPER1 expression correlates with any clinicopathologic variables and distant disease-free survival (DDFS) in patients with breast cancer, if any prognostic impact of the receptor is dependent on estrogen receptor-α (ER-α) status, and if the receptor impacts apoptotic signaling in ER-positive breast cancer cells.},
  author       = {Broselid, Stefan and Cheng, Benxu and Sjöström, Martin and Lövgren, Kristina and Klug-De Santiago, Heather L P and Belting, Mattias and Jirström, Karin and Malmström, Per and Olde, Björn and Bendahl, Pär-Ola and Werner Hartman, Linda and Fernö, Mårten and Leeb-Lundberg, Fredrik},
  issn         = {1078-0432},
  language     = {eng},
  number       = {7},
  pages        = {1681--1692},
  publisher    = {American Association for Cancer Research},
  series       = {Clinical Cancer Research},
  title        = {G protein-coupled estrogen receptor is apoptotic and correlates with increased distant disease-free survival of estrogen receptor-positive breast cancer patients.},
  url          = {http://dx.doi.org/10.1158/1078-0432.CCR-12-2376},
  volume       = {19},
  year         = {2013},
}