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Adherence to the mediterranean diet and risk of breast cancer in the European prospective investigation into cancer and nutrition cohort study

Buckland, G.; Travier, N.; Cottet, V.; Gonzalez, C. A.; Lujan-Barroso, L.; Agudo, A.; Trichopoulou, A.; Lagiou, P.; Trichopoulos, D. and Peeters, P. H., et al. (2013) In International Journal of Cancer 132(12). p.2918-2927
Abstract
Epidemiological evidence suggests that the Mediterranean diet (MD) could reduce the risk of breast cancer (BC). As evidence from the prospective studies remains scarce and conflicting, we investigated the association between adherence to the MD and risk of BC among 335,062 women recruited from 1992 to 2000, in ten European countries, and followed for 11 years on average. Adherence to the MD was estimated through an adapted relative Mediterranean diet (arMED) score excluding alcohol. Cox proportional hazards regression models were used while adjusting for BC risk factors. A total of 9,009 postmenopausal and 1,216 premenopausal first primary incident invasive BC were identified (5,862 estrogen or progesterone receptor positive [ER+/PR+] and... (More)
Epidemiological evidence suggests that the Mediterranean diet (MD) could reduce the risk of breast cancer (BC). As evidence from the prospective studies remains scarce and conflicting, we investigated the association between adherence to the MD and risk of BC among 335,062 women recruited from 1992 to 2000, in ten European countries, and followed for 11 years on average. Adherence to the MD was estimated through an adapted relative Mediterranean diet (arMED) score excluding alcohol. Cox proportional hazards regression models were used while adjusting for BC risk factors. A total of 9,009 postmenopausal and 1,216 premenopausal first primary incident invasive BC were identified (5,862 estrogen or progesterone receptor positive [ER+/PR+] and 1,018 estrogen and progesterone receptor negative [ER/PR]). The arMED was inversely associated with the risk of BC overall and in postmenopausal women (high vs. low arMED score; hazard ratio [HR] = 0.94 [95% confidence interval [CI]: 0.88, 1.00] ptrend = 0.048, and HR = 0.93 [95% CI: 0.87, 0.99] ptrend = 0.037, respectively). The association was more pronounced in ER/PR tumors (HR = 0.80 [95% CI: 0.65, 0.99] ptrend = 0.043). The arMED score was not associated with BC in premenopausal women. Our findings show that adherence to a MD excluding alcohol was related to a modest reduced risk of BC in postmenopausal women, and this association was stronger in receptor-negative tumors. The results support the potential scope for BC prevention through dietary modification. (Less)
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keywords
breast cancer, Europe, Mediterranean diet, prospective studies
in
International Journal of Cancer
volume
132
issue
12
pages
2918 - 2927
publisher
John Wiley & Sons
external identifiers
  • wos:000317593100022
  • scopus:84876136733
ISSN
0020-7136
DOI
10.1002/ijc.27958
language
English
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yes
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1db33ea3-5df9-443d-a918-54e4772ea584 (old id 3738827)
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2013-06-03 08:31:00
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2019-03-19 01:08:41
@article{1db33ea3-5df9-443d-a918-54e4772ea584,
  abstract     = {Epidemiological evidence suggests that the Mediterranean diet (MD) could reduce the risk of breast cancer (BC). As evidence from the prospective studies remains scarce and conflicting, we investigated the association between adherence to the MD and risk of BC among 335,062 women recruited from 1992 to 2000, in ten European countries, and followed for 11 years on average. Adherence to the MD was estimated through an adapted relative Mediterranean diet (arMED) score excluding alcohol. Cox proportional hazards regression models were used while adjusting for BC risk factors. A total of 9,009 postmenopausal and 1,216 premenopausal first primary incident invasive BC were identified (5,862 estrogen or progesterone receptor positive [ER+/PR+] and 1,018 estrogen and progesterone receptor negative [ER/PR]). The arMED was inversely associated with the risk of BC overall and in postmenopausal women (high vs. low arMED score; hazard ratio [HR] = 0.94 [95% confidence interval [CI]: 0.88, 1.00] ptrend = 0.048, and HR = 0.93 [95% CI: 0.87, 0.99] ptrend = 0.037, respectively). The association was more pronounced in ER/PR tumors (HR = 0.80 [95% CI: 0.65, 0.99] ptrend = 0.043). The arMED score was not associated with BC in premenopausal women. Our findings show that adherence to a MD excluding alcohol was related to a modest reduced risk of BC in postmenopausal women, and this association was stronger in receptor-negative tumors. The results support the potential scope for BC prevention through dietary modification.},
  author       = {Buckland, G. and Travier, N. and Cottet, V. and Gonzalez, C. A. and Lujan-Barroso, L. and Agudo, A. and Trichopoulou, A. and Lagiou, P. and Trichopoulos, D. and Peeters, P. H. and May, A. and Bueno-de-Mesquita, H. B. and Duijnhoven, F. J. Bvan and Key, T. J. and Allen, N. and Khaw, K. T. and Wareham, N. and Romieu, I. and McCormack, V. and Boutron-Ruault, M. and Clavel-Chapelon, F. and Panico, S. and Agnoli, C. and Palli, D. and Tumino, R. and Vineis, P. and Amiano, P. and Barricarte, A. and Rodriguez, L. and Sanchez, M. J. and Chirlaque, M. D. and Kaaks, R. and Teucher, B. and Boeing, H. and Bergmann, M. M. and Overvad, K. and Dahm, C. C. and Tjonneland, A. and Olsen, A. and Manjer, Jonas and Wirfält, Elisabet and Hallmans, G. and Johansson, I. and Lund, E. and Hjartaker, A. and Skeie, G. and Vergnaud, A. C. and Norat, T. and Romaguera, D. and Riboli, E.},
  issn         = {0020-7136},
  keyword      = {breast cancer,Europe,Mediterranean diet,prospective studies},
  language     = {eng},
  number       = {12},
  pages        = {2918--2927},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Adherence to the mediterranean diet and risk of breast cancer in the European prospective investigation into cancer and nutrition cohort study},
  url          = {http://dx.doi.org/10.1002/ijc.27958},
  volume       = {132},
  year         = {2013},
}