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Postprandial triglyceride levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants

Stenkula, Karin G. LU ; Klemendz, Lisa Esbjörnsson LU ; Fryklund, Claes LU ; Wierup, Nils LU ; Alsalim, Wathik LU ; Landin-Olsson, Mona LU ; Trinh, Lena LU ; Månsson, Sven LU orcid and Bennet, Louise LU orcid (2022) In Lipids in Health and Disease 21. p.1-12
Abstract

Purpose: Previous studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with disturbed fat metabolism and cardiovascular disease (CVD). However, fat metabolism is poorly investigated comparing Middle Eastern and European ethnicities. Methods: This observational study included 26 Iraqi and 16 Swedish-born men without T2D or clinical risk factors for CVD. An oral fat tolerance test (OFTT) was performed, where plasma triglycerides (p-TG) were measured for 6 h. mRNA expression and adipocyte size were measured in subcutaneous adipose tissue biopsies collected prior to OFTT, and... (More)

Purpose: Previous studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with disturbed fat metabolism and cardiovascular disease (CVD). However, fat metabolism is poorly investigated comparing Middle Eastern and European ethnicities. Methods: This observational study included 26 Iraqi and 16 Swedish-born men without T2D or clinical risk factors for CVD. An oral fat tolerance test (OFTT) was performed, where plasma triglycerides (p-TG) were measured for 6 h. mRNA expression and adipocyte size were measured in subcutaneous adipose tissue biopsies collected prior to OFTT, and magnetic resonance imaging was conducted to assess body fat distribution. Results: The median p-TG accumulation was higher and the clearance slower among Iraqis than Swedes. None of the groups reached their fasting p-TG (Iraqis 1.55 mmol/l; Swedes 0.95 mmol/l) after 6 h (Iraqis p-TG 3.10 mmol/l; Swedes p-TG 1.50 mmol/l). Adipocyte size, mRNA expression, and fat accumulation in the liver, muscle and abdomen were similar in both groups. Conclusion: Postprandial p-TG levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants without CVD risk factors.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adipose tissue, Cardiovascular disease, Ethnicity, Fat distribution, Oral fat tolerance test, Plasma triglycerides, Type 2 diabetes
in
Lipids in Health and Disease
volume
21
article number
68
pages
1 - 12
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85135573260
  • pmid:35927727
ISSN
1476-511X
DOI
10.1186/s12944-022-01679-x
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2022, The Author(s).
id
3ba34f2f-f874-40ad-8dd7-06138e09ae00
date added to LUP
2022-09-01 17:52:03
date last changed
2024-06-10 22:38:00
@article{3ba34f2f-f874-40ad-8dd7-06138e09ae00,
  abstract     = {{<p>Purpose: Previous studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with disturbed fat metabolism and cardiovascular disease (CVD). However, fat metabolism is poorly investigated comparing Middle Eastern and European ethnicities. Methods: This observational study included 26 Iraqi and 16 Swedish-born men without T2D or clinical risk factors for CVD. An oral fat tolerance test (OFTT) was performed, where plasma triglycerides (p-TG) were measured for 6 h. mRNA expression and adipocyte size were measured in subcutaneous adipose tissue biopsies collected prior to OFTT, and magnetic resonance imaging was conducted to assess body fat distribution. Results: The median p-TG accumulation was higher and the clearance slower among Iraqis than Swedes. None of the groups reached their fasting p-TG (Iraqis 1.55 mmol/l; Swedes 0.95 mmol/l) after 6 h (Iraqis p-TG 3.10 mmol/l; Swedes p-TG 1.50 mmol/l). Adipocyte size, mRNA expression, and fat accumulation in the liver, muscle and abdomen were similar in both groups. Conclusion: Postprandial p-TG levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants without CVD risk factors.</p>}},
  author       = {{Stenkula, Karin G. and Klemendz, Lisa Esbjörnsson and Fryklund, Claes and Wierup, Nils and Alsalim, Wathik and Landin-Olsson, Mona and Trinh, Lena and Månsson, Sven and Bennet, Louise}},
  issn         = {{1476-511X}},
  keywords     = {{Adipose tissue; Cardiovascular disease; Ethnicity; Fat distribution; Oral fat tolerance test; Plasma triglycerides; Type 2 diabetes}},
  language     = {{eng}},
  pages        = {{1--12}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Lipids in Health and Disease}},
  title        = {{Postprandial triglyceride levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants}},
  url          = {{http://dx.doi.org/10.1186/s12944-022-01679-x}},
  doi          = {{10.1186/s12944-022-01679-x}},
  volume       = {{21}},
  year         = {{2022}},
}