Postprandial triglyceride levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants
(2022) In Lipids in Health and Disease 21. p.1-12- Abstract
Purpose: Previous studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with disturbed fat metabolism and cardiovascular disease (CVD). However, fat metabolism is poorly investigated comparing Middle Eastern and European ethnicities. Methods: This observational study included 26 Iraqi and 16 Swedish-born men without T2D or clinical risk factors for CVD. An oral fat tolerance test (OFTT) was performed, where plasma triglycerides (p-TG) were measured for 6 h. mRNA expression and adipocyte size were measured in subcutaneous adipose tissue biopsies collected prior to OFTT, and... (More)
Purpose: Previous studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with disturbed fat metabolism and cardiovascular disease (CVD). However, fat metabolism is poorly investigated comparing Middle Eastern and European ethnicities. Methods: This observational study included 26 Iraqi and 16 Swedish-born men without T2D or clinical risk factors for CVD. An oral fat tolerance test (OFTT) was performed, where plasma triglycerides (p-TG) were measured for 6 h. mRNA expression and adipocyte size were measured in subcutaneous adipose tissue biopsies collected prior to OFTT, and magnetic resonance imaging was conducted to assess body fat distribution. Results: The median p-TG accumulation was higher and the clearance slower among Iraqis than Swedes. None of the groups reached their fasting p-TG (Iraqis 1.55 mmol/l; Swedes 0.95 mmol/l) after 6 h (Iraqis p-TG 3.10 mmol/l; Swedes p-TG 1.50 mmol/l). Adipocyte size, mRNA expression, and fat accumulation in the liver, muscle and abdomen were similar in both groups. Conclusion: Postprandial p-TG levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants without CVD risk factors.
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- author
- Stenkula, Karin G. LU ; Klemendz, Lisa Esbjörnsson LU ; Fryklund, Claes LU ; Wierup, Nils LU ; Alsalim, Wathik LU ; Landin-Olsson, Mona LU ; Trinh, Lena LU ; Månsson, Sven LU and Bennet, Louise LU
- organization
-
- Glucose Transport and Protein Trafficking (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- Neuroendocrine Cell Biology (research group)
- Medicine, Lund
- Diabetes lab (research group)
- EpiHealth: Epidemiology for Health
- Medical Radiation Physics, Malmö (research group)
- Family Medicine and Community Medicine (research group)
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adipose tissue, Cardiovascular disease, Ethnicity, Fat distribution, Oral fat tolerance test, Plasma triglycerides, Type 2 diabetes
- in
- Lipids in Health and Disease
- volume
- 21
- article number
- 68
- pages
- 1 - 12
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:35927727
- scopus:85135573260
- ISSN
- 1476-511X
- DOI
- 10.1186/s12944-022-01679-x
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2022, The Author(s).
- id
- 3ba34f2f-f874-40ad-8dd7-06138e09ae00
- date added to LUP
- 2022-09-01 17:52:03
- date last changed
- 2024-09-17 07:53:27
@article{3ba34f2f-f874-40ad-8dd7-06138e09ae00, abstract = {{<p>Purpose: Previous studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with disturbed fat metabolism and cardiovascular disease (CVD). However, fat metabolism is poorly investigated comparing Middle Eastern and European ethnicities. Methods: This observational study included 26 Iraqi and 16 Swedish-born men without T2D or clinical risk factors for CVD. An oral fat tolerance test (OFTT) was performed, where plasma triglycerides (p-TG) were measured for 6 h. mRNA expression and adipocyte size were measured in subcutaneous adipose tissue biopsies collected prior to OFTT, and magnetic resonance imaging was conducted to assess body fat distribution. Results: The median p-TG accumulation was higher and the clearance slower among Iraqis than Swedes. None of the groups reached their fasting p-TG (Iraqis 1.55 mmol/l; Swedes 0.95 mmol/l) after 6 h (Iraqis p-TG 3.10 mmol/l; Swedes p-TG 1.50 mmol/l). Adipocyte size, mRNA expression, and fat accumulation in the liver, muscle and abdomen were similar in both groups. Conclusion: Postprandial p-TG levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants without CVD risk factors.</p>}}, author = {{Stenkula, Karin G. and Klemendz, Lisa Esbjörnsson and Fryklund, Claes and Wierup, Nils and Alsalim, Wathik and Landin-Olsson, Mona and Trinh, Lena and Månsson, Sven and Bennet, Louise}}, issn = {{1476-511X}}, keywords = {{Adipose tissue; Cardiovascular disease; Ethnicity; Fat distribution; Oral fat tolerance test; Plasma triglycerides; Type 2 diabetes}}, language = {{eng}}, pages = {{1--12}}, publisher = {{BioMed Central (BMC)}}, series = {{Lipids in Health and Disease}}, title = {{Postprandial triglyceride levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants}}, url = {{http://dx.doi.org/10.1186/s12944-022-01679-x}}, doi = {{10.1186/s12944-022-01679-x}}, volume = {{21}}, year = {{2022}}, }