Dietary Fiber and the Hippocampal Neurogenic Niche in a Model of Pelvic Radiotherapy
(2021) In Neuroscience 475. p.137-147- Abstract
We sought to determine whether radiation to the colorectum had an impact on parameters of hippocampal neurogenesis and, if so, whether it could be modulated by a fiber-rich diet. Male C57BL/6J mice were fed a diet containing bioprocessed oat bran or a fiber-free diet, starting two weeks before colorectal irradiation with 4 fractions of 8 Gray or sham-irradiation. Diets were then continued for 1, 6 or 18 weeks, whereafter parameters of hippocampal neurogenesis were analyzed and correlated to serum cytokine levels. No statistically significant changes in neuronal markers or cell proliferation were found at one week post-irradiation. Six weeks post-irradiation there was a decreased cell proliferation in the subgranular zone that appeared... (More)
We sought to determine whether radiation to the colorectum had an impact on parameters of hippocampal neurogenesis and, if so, whether it could be modulated by a fiber-rich diet. Male C57BL/6J mice were fed a diet containing bioprocessed oat bran or a fiber-free diet, starting two weeks before colorectal irradiation with 4 fractions of 8 Gray or sham-irradiation. Diets were then continued for 1, 6 or 18 weeks, whereafter parameters of hippocampal neurogenesis were analyzed and correlated to serum cytokine levels. No statistically significant changes in neuronal markers or cell proliferation were found at one week post-irradiation. Six weeks post-irradiation there was a decreased cell proliferation in the subgranular zone that appeared slightly more pronounced in irradiated animals on a fiber-free diet and increased numbers of immature neurons per mm2 dentate gyrus in the irradiated mice, with a statistically significant increase in mice on a fiber-rich diet. Microglial abundancy was similar between all groups. 18 weeks post-irradiation, a fiber-free diet had reduced the number of immature neurons, whereas irradiation resulted in an increase. Despite this, the population of mature neurons was stable. Analysis of serum cytokines revealed a negative correlation between MIP1-α and the number of immature neurons one week after irradiation, regardless of diet. Our findings show that pelvic radiotherapy has the potential to cause a long-lasting impact on hippocampal neurogenesis, and dietary interventions may modulate this impact. More in-depth studies on the relationship between irradiation-induced intestinal injury and brain health are warranted.
(Less)
- author
- organization
- publishing date
- 2021-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- bioprocessed oat bran, dietary fiber, hippocampal neurogenesis, intestine, irradiation
- in
- Neuroscience
- volume
- 475
- pages
- 11 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85115988996
- pmid:34487821
- ISSN
- 0306-4522
- DOI
- 10.1016/j.neuroscience.2021.08.030
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 The Authors
- id
- 3d7c4e0a-6644-4887-9acb-04ed53e1a44d
- date added to LUP
- 2021-10-19 11:24:55
- date last changed
- 2024-06-15 18:21:01
@article{3d7c4e0a-6644-4887-9acb-04ed53e1a44d,
abstract = {{<p>We sought to determine whether radiation to the colorectum had an impact on parameters of hippocampal neurogenesis and, if so, whether it could be modulated by a fiber-rich diet. Male C57BL/6J mice were fed a diet containing bioprocessed oat bran or a fiber-free diet, starting two weeks before colorectal irradiation with 4 fractions of 8 Gray or sham-irradiation. Diets were then continued for 1, 6 or 18 weeks, whereafter parameters of hippocampal neurogenesis were analyzed and correlated to serum cytokine levels. No statistically significant changes in neuronal markers or cell proliferation were found at one week post-irradiation. Six weeks post-irradiation there was a decreased cell proliferation in the subgranular zone that appeared slightly more pronounced in irradiated animals on a fiber-free diet and increased numbers of immature neurons per mm<sup>2</sup> dentate gyrus in the irradiated mice, with a statistically significant increase in mice on a fiber-rich diet. Microglial abundancy was similar between all groups. 18 weeks post-irradiation, a fiber-free diet had reduced the number of immature neurons, whereas irradiation resulted in an increase. Despite this, the population of mature neurons was stable. Analysis of serum cytokines revealed a negative correlation between MIP1-α and the number of immature neurons one week after irradiation, regardless of diet. Our findings show that pelvic radiotherapy has the potential to cause a long-lasting impact on hippocampal neurogenesis, and dietary interventions may modulate this impact. More in-depth studies on the relationship between irradiation-induced intestinal injury and brain health are warranted.</p>}},
author = {{Devarakonda, Sravani and Malipatlolla, Dilip Kumar and Patel, Piyush and Grandér, Rita and Kuhn, H. Georg and Steineck, Gunnar and Sjöberg, Fei and Rascón, Ana and Nyman, Margareta and Eriksson, Yohanna and Danial, Jolie and Ittner, Ella and Naama Walid, Rukaya and Prykhodko, Olena and Masuram, Spandana and Kalm, Marie and Bull, Cecilia}},
issn = {{0306-4522}},
keywords = {{bioprocessed oat bran; dietary fiber; hippocampal neurogenesis; intestine; irradiation}},
language = {{eng}},
pages = {{137--147}},
publisher = {{Elsevier}},
series = {{Neuroscience}},
title = {{Dietary Fiber and the Hippocampal Neurogenic Niche in a Model of Pelvic Radiotherapy}},
url = {{http://dx.doi.org/10.1016/j.neuroscience.2021.08.030}},
doi = {{10.1016/j.neuroscience.2021.08.030}},
volume = {{475}},
year = {{2021}},
}