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Overall cancer incidence not increased after prosthetic knee replacement : 14,551 patients followed for 66,622 person-years

Lewold, S LU ; Olsson, Håkan LU ; Gustafson, P LU ; Rydholm, A LU and Lidgren, L LU (1996) In International Journal of Cancer 68(1). p.3-30
Abstract

It is unknown whether patients as a consequence of prosthetic joint replacement are at a higher risk of developing cancer. We therefore analyzed cancer incidence following prosthetic knee replacement (TKR). The observed cancer incidence in 14,551 patients from the population-based Swedish Knee Arthroplasty Register who have undergone TKR because of osteoarthrosis (OA, n = 10,120) or rheumatoid arthritis (RA, n = 4431) were compared with the expected cancer incidence for a Swedish reference population. The cohort was followed for a total of 66,622 person-years. We followed 33% of the patients with OA and 59% of those with RA for more than 5 years. All patients who underwent TKR, whether for OA or for RA, had lower than expected total... (More)

It is unknown whether patients as a consequence of prosthetic joint replacement are at a higher risk of developing cancer. We therefore analyzed cancer incidence following prosthetic knee replacement (TKR). The observed cancer incidence in 14,551 patients from the population-based Swedish Knee Arthroplasty Register who have undergone TKR because of osteoarthrosis (OA, n = 10,120) or rheumatoid arthritis (RA, n = 4431) were compared with the expected cancer incidence for a Swedish reference population. The cohort was followed for a total of 66,622 person-years. We followed 33% of the patients with OA and 59% of those with RA for more than 5 years. All patients who underwent TKR, whether for OA or for RA, had lower than expected total cancer incidence. We found a markedly low incidence of colorectal carcinoma, especially in patients with RA. Our results do not indicate an increased incidence of cancer following TKR.

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organization
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Contribution to journal
publication status
published
subject
keywords
Arthritis, Rheumatoid, Colorectal Neoplasms, Female, Humans, Knee Prosthesis, Male, Neoplasms, Osteoarthritis, Sweden, Time Factors
in
International Journal of Cancer
volume
68
issue
1
pages
4 pages
publisher
John Wiley & Sons
external identifiers
  • Scopus:0029853570
ISSN
0020-7136
DOI
10.1002/(SICI)1097-0215(19960927)68:1<30::AID-IJC6>3.0.CO;2-Y
language
English
LU publication?
yes
id
403425a1-8626-4410-a168-038a1fed6f27
date added to LUP
2016-09-18 12:50:53
date last changed
2017-01-01 08:34:10
@article{403425a1-8626-4410-a168-038a1fed6f27,
  abstract     = {<p>It is unknown whether patients as a consequence of prosthetic joint replacement are at a higher risk of developing cancer. We therefore analyzed cancer incidence following prosthetic knee replacement (TKR). The observed cancer incidence in 14,551 patients from the population-based Swedish Knee Arthroplasty Register who have undergone TKR because of osteoarthrosis (OA, n = 10,120) or rheumatoid arthritis (RA, n = 4431) were compared with the expected cancer incidence for a Swedish reference population. The cohort was followed for a total of 66,622 person-years. We followed 33% of the patients with OA and 59% of those with RA for more than 5 years. All patients who underwent TKR, whether for OA or for RA, had lower than expected total cancer incidence. We found a markedly low incidence of colorectal carcinoma, especially in patients with RA. Our results do not indicate an increased incidence of cancer following TKR.</p>},
  author       = {Lewold, S and Olsson, Håkan and Gustafson, P and Rydholm, A and Lidgren, L},
  issn         = {0020-7136},
  keyword      = {Arthritis, Rheumatoid,Colorectal Neoplasms,Female,Humans,Knee Prosthesis,Male,Neoplasms,Osteoarthritis,Sweden,Time Factors},
  language     = {eng},
  month        = {09},
  number       = {1},
  pages        = {3--30},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Overall cancer incidence not increased after prosthetic knee replacement : 14,551 patients followed for 66,622 person-years},
  url          = {http://dx.doi.org/10.1002/(SICI)1097-0215(19960927)68:1<30::AID-IJC6>3.0.CO;2-Y},
  volume       = {68},
  year         = {1996},
}