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Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

Jakszyn, Paula ; Cayssials, Valerie ; Buckland, Genevieve ; Perez-Cornago, Aurora ; Weiderpass, Elisabete ; Boeing, Heiner ; Bergmann, Manuela M. ; Vulcan, Alexandra LU ; Ohlsson, Bodil LU and Masala, Giovanna , et al. (2020) In International Journal of Cancer
Abstract

Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute toward a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammatory profile and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. This cohort included 476,160 participants followed-up of 14 years and 5,991 incident CRC cases (3,897 colon and 2,094 rectal tumors). Dietary inflammatory potential was estimated using an Inflammatory Score of the Diet (ISD). An Inflammatory... (More)

Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute toward a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammatory profile and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. This cohort included 476,160 participants followed-up of 14 years and 5,991 incident CRC cases (3,897 colon and 2,094 rectal tumors). Dietary inflammatory potential was estimated using an Inflammatory Score of the Diet (ISD). An Inflammatory Profile Score (IPS) was constructed, incorporating the ISD, physical activity level and abdominal obesity. The associations between the ISD and CRC and IPS and CRC were assessed using multivariable regression models. More proinflammatory diets were related to a higher CRC risk, particularly for colon cancer; hazard ratio (HR) for highest versus lowest ISD quartile was 1.15 (95% confidence interval [CI] 1.04–1.27) for CRC, 1.24 (95% CI 1.09–1.41) for colon cancer and 0.99 (95% CI 0.83–1.17) for rectal cancer. Associations were more pronounced in men and not significant in women. The IPS was associated with CRC risk, particularly colon cancer among men; HRs for the highest versus lowest IPS was 1.62 (95% CI 1.31–2.01) for colon cancer overall and 2.11 (95% CI 1.50–2.97) for colon cancer in men. Our study shows that more proinflammatory diets and a more inflammatory profile are associated with higher risk of CRC, principally colon cancer and in men.

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association, colorectal cancer, epidemiology, Europe, inflammatory potential of the diet, prospective cohort
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International Journal of Cancer
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John Wiley and Sons Inc.
external identifiers
  • scopus:85078900968
  • pmid:31945199
ISSN
0020-7136
DOI
10.1002/ijc.32870
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English
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yes
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435a969d-5ab8-4163-944b-4a2c919f4963
date added to LUP
2020-02-17 12:45:54
date last changed
2020-02-26 07:41:54
@article{435a969d-5ab8-4163-944b-4a2c919f4963,
  abstract     = {<p>Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute toward a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammatory profile and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. This cohort included 476,160 participants followed-up of 14 years and 5,991 incident CRC cases (3,897 colon and 2,094 rectal tumors). Dietary inflammatory potential was estimated using an Inflammatory Score of the Diet (ISD). An Inflammatory Profile Score (IPS) was constructed, incorporating the ISD, physical activity level and abdominal obesity. The associations between the ISD and CRC and IPS and CRC were assessed using multivariable regression models. More proinflammatory diets were related to a higher CRC risk, particularly for colon cancer; hazard ratio (HR) for highest versus lowest ISD quartile was 1.15 (95% confidence interval [CI] 1.04–1.27) for CRC, 1.24 (95% CI 1.09–1.41) for colon cancer and 0.99 (95% CI 0.83–1.17) for rectal cancer. Associations were more pronounced in men and not significant in women. The IPS was associated with CRC risk, particularly colon cancer among men; HRs for the highest versus lowest IPS was 1.62 (95% CI 1.31–2.01) for colon cancer overall and 2.11 (95% CI 1.50–2.97) for colon cancer in men. Our study shows that more proinflammatory diets and a more inflammatory profile are associated with higher risk of CRC, principally colon cancer and in men.</p>},
  author       = {Jakszyn, Paula and Cayssials, Valerie and Buckland, Genevieve and Perez-Cornago, Aurora and Weiderpass, Elisabete and Boeing, Heiner and Bergmann, Manuela M. and Vulcan, Alexandra and Ohlsson, Bodil and Masala, Giovanna and Cross, Amanda J. and Riboli, Elio and Ricceri, Fulvio and Dahm, Christina C. and Nyvang, Dorthe and Katzke, Verena A. and Kühn, Tilman and Kyrø, Cecilie and Tjønneland, Anne and Ward, Heather A. and Tsilidis, Konstantinos K. and Skeie, Guri and Sieri, Sabina and Sanchez, Maria Jose and Huerta, Jose M. and Amiano, Pilar and Lasheras, Cristina and Ardanaz, Eva and Mahamat-Saleh, Yahya and Boutron-Ruault, Marie Christine and Carbonnel, Franck and Panico, Salvatore and Peppa, Eleni and Trichopoulou, Antonia and Karakatsani, Anna and Tumino, Rosario and Vermeulen, Roel and Jenab, Mazda and Gunter, Marc and Agudo, Antonio},
  issn         = {0020-7136},
  language     = {eng},
  publisher    = {John Wiley and Sons Inc.},
  series       = {International Journal of Cancer},
  title        = {Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study},
  url          = {http://dx.doi.org/10.1002/ijc.32870},
  doi          = {10.1002/ijc.32870},
  year         = {2020},
}