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Infiltration of CD3(+) and CD68(+) cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.

Sjödahl, Gottfrid LU ; Lövgren, Kristina LU ; Lauss, Martin LU ; Chebil, Gunilla; Hultman Patschan, Oliver LU ; Gudjonsson, Sigurdur LU ; Månsson, Wiking LU ; Fernö, Mårten LU ; Leandersson, Karin LU and Lindgren, David LU , et al. (2014) In Urologic Oncology 32(6). p.791-797
Abstract
Urothelial carcinoma (UC) aggressiveness is determined by tumor inherent molecular characteristics, such as molecular subtypes, as well as by host reactions directed toward the tumor. Cell types responsible for the host׳s response include tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). The aim of the present investigation was to explore the immunological response in relation to UC molecular subtypes and to evaluate the prognostic effect of TIL and TAM counts in tissue sections from muscle-invasive (MI) tumors.
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type
Contribution to journal
publication status
published
subject
in
Urologic Oncology
volume
32
issue
6
pages
791 - 797
publisher
Elsevier
external identifiers
  • pmid:24794251
  • wos:000340343400008
  • scopus:84905181859
ISSN
1873-2496
DOI
10.1016/j.urolonc.2014.02.007
language
English
LU publication?
yes
id
2ebd5007-c07c-475f-9add-ab3c35bb3384 (old id 4455891)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24794251?dopt=Abstract
date added to LUP
2014-06-03 19:14:27
date last changed
2017-11-05 03:13:06
@article{2ebd5007-c07c-475f-9add-ab3c35bb3384,
  abstract     = {Urothelial carcinoma (UC) aggressiveness is determined by tumor inherent molecular characteristics, such as molecular subtypes, as well as by host reactions directed toward the tumor. Cell types responsible for the host׳s response include tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). The aim of the present investigation was to explore the immunological response in relation to UC molecular subtypes and to evaluate the prognostic effect of TIL and TAM counts in tissue sections from muscle-invasive (MI) tumors.},
  author       = {Sjödahl, Gottfrid and Lövgren, Kristina and Lauss, Martin and Chebil, Gunilla and Hultman Patschan, Oliver and Gudjonsson, Sigurdur and Månsson, Wiking and Fernö, Mårten and Leandersson, Karin and Lindgren, David and Liedberg, Fredrik and Höglund, Mattias},
  issn         = {1873-2496},
  language     = {eng},
  number       = {6},
  pages        = {791--797},
  publisher    = {Elsevier},
  series       = {Urologic Oncology},
  title        = {Infiltration of CD3(+) and CD68(+) cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.},
  url          = {http://dx.doi.org/10.1016/j.urolonc.2014.02.007},
  volume       = {32},
  year         = {2014},
}