Advanced

Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study

Emaus, Marleen J.; van Gils, Carla H.; Bakker, Marije F.; Bisschop, Charlotte N. Steins; Monninkhof, Evelyn M.; Bueno-de-Mesquita, H. B(as); Travier, Noemie; Berentzen, Tina Landsvig; Overvad, Kim and Tjonneland, Anne, et al. (2014) In International Journal of Cancer 135(12). p.2887-2899
Abstract
Long-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40-50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition cohort, with information on anthropometric measures at recruitment and after a median follow-up of 4.3 years. Annual weight change was categorized using quintiles taking quintile 2 and 3 as the reference category (-0.44 to 0.36 kg/year). Multivariable... (More)
Long-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40-50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition cohort, with information on anthropometric measures at recruitment and after a median follow-up of 4.3 years. Annual weight change was categorized using quintiles taking quintile 2 and 3 as the reference category (-0.44 to 0.36 kg/year). Multivariable Cox proportional hazards regression analysis was used to examine the association. 205,723 women were included and 4,663 incident breast cancer cases were diagnosed during a median follow-up of 7.5 years (from second weight assessment onward). High weight gain (Q5: 0.83-4.98 kg/year) was related to a slightly, but significantly higher breast cancer risk (HRQ5_versus_Q2/3: 1.09, 95% CI: 1.01-1.18). The association was more pronounced for breast cancer diagnosed before or at age 50 (HRQ5_versus_Q2/3: 1.37, 95% CI: 1.02-1.85). Weight loss was not associated with breast cancer risk. There was no evidence for heterogeneity by hormone receptor status. In conclusion, high weight gain in middle adulthood increases the risk of breast cancer. The association seems to be more pronounced for breast cancer diagnosed before or at age 50. Our results illustrate the importance of avoiding weight gain in middle adulthood. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breast cancer, adult weight gain, menopausal status, estrogen receptor, progesterone receptor
in
International Journal of Cancer
volume
135
issue
12
pages
2887 - 2899
publisher
John Wiley & Sons
external identifiers
  • wos:000343055600015
  • scopus:84908873953
ISSN
0020-7136
DOI
10.1002/ijc.28926
language
English
LU publication?
yes
id
98732c14-f299-4176-b60a-dd8eea283353 (old id 4783941)
date added to LUP
2014-11-21 11:26:17
date last changed
2017-11-19 03:19:53
@article{98732c14-f299-4176-b60a-dd8eea283353,
  abstract     = {Long-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40-50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition cohort, with information on anthropometric measures at recruitment and after a median follow-up of 4.3 years. Annual weight change was categorized using quintiles taking quintile 2 and 3 as the reference category (-0.44 to 0.36 kg/year). Multivariable Cox proportional hazards regression analysis was used to examine the association. 205,723 women were included and 4,663 incident breast cancer cases were diagnosed during a median follow-up of 7.5 years (from second weight assessment onward). High weight gain (Q5: 0.83-4.98 kg/year) was related to a slightly, but significantly higher breast cancer risk (HRQ5_versus_Q2/3: 1.09, 95% CI: 1.01-1.18). The association was more pronounced for breast cancer diagnosed before or at age 50 (HRQ5_versus_Q2/3: 1.37, 95% CI: 1.02-1.85). Weight loss was not associated with breast cancer risk. There was no evidence for heterogeneity by hormone receptor status. In conclusion, high weight gain in middle adulthood increases the risk of breast cancer. The association seems to be more pronounced for breast cancer diagnosed before or at age 50. Our results illustrate the importance of avoiding weight gain in middle adulthood.},
  author       = {Emaus, Marleen J. and van Gils, Carla H. and Bakker, Marije F. and Bisschop, Charlotte N. Steins and Monninkhof, Evelyn M. and Bueno-de-Mesquita, H. B(as) and Travier, Noemie and Berentzen, Tina Landsvig and Overvad, Kim and Tjonneland, Anne and Romieu, Isabelle and Rinaldi, Sabina and Chajes, Veronique and Gunter, Marc J. and Clavel-Chapelon, Francoise and Fagherazzi, Guy and Mesrine, Sylvie and Chang-Claude, Jenny and Kaaks, Rudolf and Boeing, Heiner and Aleksandrova, Krasimira and Trichopoulou, Antonia and Naska, Androniki and Orfanos, Philippos and Palli, Domenico and Agnoli, Claudia and Tumino, Rosario and Vineis, Paolo and Mattiello, Amalia and Braaten, Tonje and Borch, Kristin Benjaminsen and Lund, Eiliv and Menendez, Virginia and Sanchez, Maria-Jose and Navarro, Carmen and Barricarte, Aurelio and Amiano, Pilar and Sund, Malin and Andersson, Anne and Borgquist, Signe and Olsson, Åsa and Khaw, Kay-Tee and Wareham, Nick and Travis, Ruth C. and Riboli, Elio and Peeters, Petra H. M. and May, Anne M.},
  issn         = {0020-7136},
  keyword      = {breast cancer,adult weight gain,menopausal status,estrogen receptor,progesterone receptor},
  language     = {eng},
  number       = {12},
  pages        = {2887--2899},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study},
  url          = {http://dx.doi.org/10.1002/ijc.28926},
  volume       = {135},
  year         = {2014},
}