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Do pathological parameters differ with regard to breast density and mode of detection in breast cancer? The Malmö Diet and Cancer Study.

Sartor, Hanna LU ; Borgquist, Signe LU ; Werner Hartman, Linda LU and Zackrisson, Sophia LU (2015) In Breast 24(1). p.12-17
Abstract
Our aim was to study how breast density relates to tumor characteristics in breast cancer with emphasis on mode of detection. Among 17,035 women in the Malmö Diet and Cancer Study 826 incident cases have been diagnosed (1991-2007). Data on tumor characteristics, mode of detection, and density at diagnosis were collected. Associations between density and tumor characteristics were analyzed using logistic and ordinal logistic regression models yielding OR and 95% CI. Adjustments for age at diagnosis, BMI at baseline, and the mode of detection, were performed. In denser breasts, large tumor size was more frequent (ORadj 1.59 (1.26-2.01)) as was lymph node involvement (ORadj 1.32 (1.00-1.74)). Further, the higher the density, the lower the... (More)
Our aim was to study how breast density relates to tumor characteristics in breast cancer with emphasis on mode of detection. Among 17,035 women in the Malmö Diet and Cancer Study 826 incident cases have been diagnosed (1991-2007). Data on tumor characteristics, mode of detection, and density at diagnosis were collected. Associations between density and tumor characteristics were analyzed using logistic and ordinal logistic regression models yielding OR and 95% CI. Adjustments for age at diagnosis, BMI at baseline, and the mode of detection, were performed. In denser breasts, large tumor size was more frequent (ORadj 1.59 (1.26-2.01)) as was lymph node involvement (ORadj 1.32 (1.00-1.74)). Further, the higher the density, the lower the grade (ORadj 0.73 (0.53-1.02) for having higher grade), in screening-detected invasive breast cancer. Our findings stress the importance of considering the impact of density in mammography image interpretation and the possible associations with tumor aggressiveness. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Breast
volume
24
issue
1
pages
12 - 17
publisher
Churchill Livingstone
external identifiers
  • pmid:25433452
  • wos:000347722300002
  • scopus:84920371874
ISSN
1532-3080
DOI
10.1016/j.breast.2014.10.006
language
English
LU publication?
yes
id
4220934c-bad6-4583-aa88-a07f8ae45d21 (old id 4913715)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25433452?dopt=Abstract
date added to LUP
2015-01-08 13:57:23
date last changed
2017-01-01 03:05:17
@article{4220934c-bad6-4583-aa88-a07f8ae45d21,
  abstract     = {Our aim was to study how breast density relates to tumor characteristics in breast cancer with emphasis on mode of detection. Among 17,035 women in the Malmö Diet and Cancer Study 826 incident cases have been diagnosed (1991-2007). Data on tumor characteristics, mode of detection, and density at diagnosis were collected. Associations between density and tumor characteristics were analyzed using logistic and ordinal logistic regression models yielding OR and 95% CI. Adjustments for age at diagnosis, BMI at baseline, and the mode of detection, were performed. In denser breasts, large tumor size was more frequent (ORadj 1.59 (1.26-2.01)) as was lymph node involvement (ORadj 1.32 (1.00-1.74)). Further, the higher the density, the lower the grade (ORadj 0.73 (0.53-1.02) for having higher grade), in screening-detected invasive breast cancer. Our findings stress the importance of considering the impact of density in mammography image interpretation and the possible associations with tumor aggressiveness.},
  author       = {Sartor, Hanna and Borgquist, Signe and Werner Hartman, Linda and Zackrisson, Sophia},
  issn         = {1532-3080},
  language     = {eng},
  number       = {1},
  pages        = {12--17},
  publisher    = {Churchill Livingstone},
  series       = {Breast},
  title        = {Do pathological parameters differ with regard to breast density and mode of detection in breast cancer? The Malmö Diet and Cancer Study.},
  url          = {http://dx.doi.org/10.1016/j.breast.2014.10.006},
  volume       = {24},
  year         = {2015},
}