Do pathological parameters differ with regard to breast density and mode of detection in breast cancer? The Malmö Diet and Cancer Study.
(2015) In Breast 24(1). p.12-17- Abstract
- Our aim was to study how breast density relates to tumor characteristics in breast cancer with emphasis on mode of detection. Among 17,035 women in the Malmö Diet and Cancer Study 826 incident cases have been diagnosed (1991-2007). Data on tumor characteristics, mode of detection, and density at diagnosis were collected. Associations between density and tumor characteristics were analyzed using logistic and ordinal logistic regression models yielding OR and 95% CI. Adjustments for age at diagnosis, BMI at baseline, and the mode of detection, were performed. In denser breasts, large tumor size was more frequent (ORadj 1.59 (1.26-2.01)) as was lymph node involvement (ORadj 1.32 (1.00-1.74)). Further, the higher the density, the lower the... (More)
- Our aim was to study how breast density relates to tumor characteristics in breast cancer with emphasis on mode of detection. Among 17,035 women in the Malmö Diet and Cancer Study 826 incident cases have been diagnosed (1991-2007). Data on tumor characteristics, mode of detection, and density at diagnosis were collected. Associations between density and tumor characteristics were analyzed using logistic and ordinal logistic regression models yielding OR and 95% CI. Adjustments for age at diagnosis, BMI at baseline, and the mode of detection, were performed. In denser breasts, large tumor size was more frequent (ORadj 1.59 (1.26-2.01)) as was lymph node involvement (ORadj 1.32 (1.00-1.74)). Further, the higher the density, the lower the grade (ORadj 0.73 (0.53-1.02) for having higher grade), in screening-detected invasive breast cancer. Our findings stress the importance of considering the impact of density in mammography image interpretation and the possible associations with tumor aggressiveness. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4913715
- author
- Sartor, Hanna LU ; Borgquist, Signe LU ; Werner Hartman, Linda LU and Zackrisson, Sophia LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Breast
- volume
- 24
- issue
- 1
- pages
- 12 - 17
- publisher
- Churchill Livingstone
- external identifiers
-
- pmid:25433452
- wos:000347722300002
- scopus:84920371874
- pmid:25433452
- ISSN
- 1532-3080
- DOI
- 10.1016/j.breast.2014.10.006
- language
- English
- LU publication?
- yes
- id
- 4220934c-bad6-4583-aa88-a07f8ae45d21 (old id 4913715)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25433452?dopt=Abstract
- date added to LUP
- 2016-04-01 09:53:19
- date last changed
- 2022-04-25 12:53:12
@article{4220934c-bad6-4583-aa88-a07f8ae45d21,
abstract = {{Our aim was to study how breast density relates to tumor characteristics in breast cancer with emphasis on mode of detection. Among 17,035 women in the Malmö Diet and Cancer Study 826 incident cases have been diagnosed (1991-2007). Data on tumor characteristics, mode of detection, and density at diagnosis were collected. Associations between density and tumor characteristics were analyzed using logistic and ordinal logistic regression models yielding OR and 95% CI. Adjustments for age at diagnosis, BMI at baseline, and the mode of detection, were performed. In denser breasts, large tumor size was more frequent (ORadj 1.59 (1.26-2.01)) as was lymph node involvement (ORadj 1.32 (1.00-1.74)). Further, the higher the density, the lower the grade (ORadj 0.73 (0.53-1.02) for having higher grade), in screening-detected invasive breast cancer. Our findings stress the importance of considering the impact of density in mammography image interpretation and the possible associations with tumor aggressiveness.}},
author = {{Sartor, Hanna and Borgquist, Signe and Werner Hartman, Linda and Zackrisson, Sophia}},
issn = {{1532-3080}},
language = {{eng}},
number = {{1}},
pages = {{12--17}},
publisher = {{Churchill Livingstone}},
series = {{Breast}},
title = {{Do pathological parameters differ with regard to breast density and mode of detection in breast cancer? The Malmö Diet and Cancer Study.}},
url = {{http://dx.doi.org/10.1016/j.breast.2014.10.006}},
doi = {{10.1016/j.breast.2014.10.006}},
volume = {{24}},
year = {{2015}},
}