Advanced

Manganese and selenium concentrations in umbilical cord serum and attention deficit hyperactivity disorder in childhood.

Ode, Amanda LU ; Rylander, Lars LU ; Gustafsson, Peik LU ; Lundh, Thomas LU ; Källén, Karin LU ; Olofsson, Per LU ; Ivarsson, Sten LU and Rignell-Hydbom, Anna LU (2015) In Environmental Research 137. p.373-381
Abstract
Existing evidence on the effects of manganese and selenium during fetal life on neurodevelopmental disorders is inadequate. This study aims to investigate the hypothesized relationship between fetal exposure to manganese and selenium and attention deficit hyperactivity disorder (ADHD) diagnosis in childhood. Children born between 1978 and 2000 with ADHD (n=166) were identified at the Department of Child and Adolescent Psychiatry in Malmö, Sweden. Controls from the same region (n=166) were selected from the Medical Birth Register and were matched for year of birth and maternal country of birth. Manganese and selenium were measured in umbilical cord serum. The median cord serum concentrations of manganese were 4.3μg/L in the cases and... (More)
Existing evidence on the effects of manganese and selenium during fetal life on neurodevelopmental disorders is inadequate. This study aims to investigate the hypothesized relationship between fetal exposure to manganese and selenium and attention deficit hyperactivity disorder (ADHD) diagnosis in childhood. Children born between 1978 and 2000 with ADHD (n=166) were identified at the Department of Child and Adolescent Psychiatry in Malmö, Sweden. Controls from the same region (n=166) were selected from the Medical Birth Register and were matched for year of birth and maternal country of birth. Manganese and selenium were measured in umbilical cord serum. The median cord serum concentrations of manganese were 4.3μg/L in the cases and 4.1μg/L in the controls. The corresponding concentrations of selenium were 47 and 48μg/L. When the exposures were analyzed as continuous variables no associations between cord manganese or selenium concentration and ADHD were observed. However, children with selenium concentrations above the 90th percentile had 2.5 times higher odds (95% confidence interval 1.3-5.1) of having ADHD compared to those with concentrations between the 10th and 90th percentiles. There was no significant interaction between manganese and selenium exposure (p=0.08). This study showed no association between manganese concentrations in umbilical cord serum and ADHD. The association between ADHD diagnoses in children with relatively high cord selenium was unexpected and should be interpreted with caution. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Environmental Research
volume
137
pages
373 - 381
publisher
Elsevier
external identifiers
  • scopus:84922496204
  • pmid:25601741
  • wos:000352331000045
ISSN
1096-0953
DOI
10.1016/j.envres.2015.01.001
language
English
LU publication?
yes
id
4b6777d9-1040-45d9-8c70-f4543809d968 (old id 5014416)
date added to LUP
2015-02-03 19:33:02
date last changed
2017-09-17 03:11:02
@article{4b6777d9-1040-45d9-8c70-f4543809d968,
  abstract     = {Existing evidence on the effects of manganese and selenium during fetal life on neurodevelopmental disorders is inadequate. This study aims to investigate the hypothesized relationship between fetal exposure to manganese and selenium and attention deficit hyperactivity disorder (ADHD) diagnosis in childhood. Children born between 1978 and 2000 with ADHD (n=166) were identified at the Department of Child and Adolescent Psychiatry in Malmö, Sweden. Controls from the same region (n=166) were selected from the Medical Birth Register and were matched for year of birth and maternal country of birth. Manganese and selenium were measured in umbilical cord serum. The median cord serum concentrations of manganese were 4.3μg/L in the cases and 4.1μg/L in the controls. The corresponding concentrations of selenium were 47 and 48μg/L. When the exposures were analyzed as continuous variables no associations between cord manganese or selenium concentration and ADHD were observed. However, children with selenium concentrations above the 90th percentile had 2.5 times higher odds (95% confidence interval 1.3-5.1) of having ADHD compared to those with concentrations between the 10th and 90th percentiles. There was no significant interaction between manganese and selenium exposure (p=0.08). This study showed no association between manganese concentrations in umbilical cord serum and ADHD. The association between ADHD diagnoses in children with relatively high cord selenium was unexpected and should be interpreted with caution.},
  author       = {Ode, Amanda and Rylander, Lars and Gustafsson, Peik and Lundh, Thomas and Källén, Karin and Olofsson, Per and Ivarsson, Sten and Rignell-Hydbom, Anna},
  issn         = {1096-0953},
  language     = {eng},
  pages        = {373--381},
  publisher    = {Elsevier},
  series       = {Environmental Research},
  title        = {Manganese and selenium concentrations in umbilical cord serum and attention deficit hyperactivity disorder in childhood.},
  url          = {http://dx.doi.org/10.1016/j.envres.2015.01.001},
  volume       = {137},
  year         = {2015},
}