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Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1.

Påhlman, Lisa LU ; Jögi, Annika LU ; Gram, Magnus LU ; Mori, Michiko LU and Egesten, Arne LU (2015) In BMC Pulmonary Medicine 15(1).
Abstract
Secretory leukocyte protease inhibitor (SLPI) is a protein with anti-protease and antimicrobial properties that is constitutively secreted from the airway epithelium. The importance of maintaining a balance between proteases and anti-proteases, and robust innate defence mechanisms in the airways, is exemplified by inflammatory lung conditions such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Both conditions present with a high protease burden in the airways which leads to tissue destruction. These patients also have an impaired innate immune system in the lungs with bacterial colonization and frequent airway infections. Moreover, both diseases are associated with airway hypoxia due to inflammation and mucus... (More)
Secretory leukocyte protease inhibitor (SLPI) is a protein with anti-protease and antimicrobial properties that is constitutively secreted from the airway epithelium. The importance of maintaining a balance between proteases and anti-proteases, and robust innate defence mechanisms in the airways, is exemplified by inflammatory lung conditions such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Both conditions present with a high protease burden in the airways which leads to tissue destruction. These patients also have an impaired innate immune system in the lungs with bacterial colonization and frequent airway infections. Moreover, both diseases are associated with airway hypoxia due to inflammation and mucus plugs. The aim of the present study was to investigate the role of hypoxia on SLPI production from the airway epithelium. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Pulmonary Medicine
volume
15
issue
1
publisher
BioMed Central
external identifiers
  • pmid:25778525
  • wos:000351983900001
  • scopus:84925883006
ISSN
1471-2466
DOI
10.1186/s12890-015-0016-0
language
English
LU publication?
yes
id
db98ba7b-1bc1-46e5-bdab-5f0bbca4bb99 (old id 5258447)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25778525?dopt=Abstract
date added to LUP
2015-04-13 10:24:17
date last changed
2017-11-12 03:40:03
@article{db98ba7b-1bc1-46e5-bdab-5f0bbca4bb99,
  abstract     = {Secretory leukocyte protease inhibitor (SLPI) is a protein with anti-protease and antimicrobial properties that is constitutively secreted from the airway epithelium. The importance of maintaining a balance between proteases and anti-proteases, and robust innate defence mechanisms in the airways, is exemplified by inflammatory lung conditions such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Both conditions present with a high protease burden in the airways which leads to tissue destruction. These patients also have an impaired innate immune system in the lungs with bacterial colonization and frequent airway infections. Moreover, both diseases are associated with airway hypoxia due to inflammation and mucus plugs. The aim of the present study was to investigate the role of hypoxia on SLPI production from the airway epithelium.},
  articleno    = {19},
  author       = {Påhlman, Lisa and Jögi, Annika and Gram, Magnus and Mori, Michiko and Egesten, Arne},
  issn         = {1471-2466},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {BMC Pulmonary Medicine},
  title        = {Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1.},
  url          = {http://dx.doi.org/10.1186/s12890-015-0016-0},
  volume       = {15},
  year         = {2015},
}