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Dietary Folate Intake and Breast Cancer Risk: European Prospective Investigation Into Cancer and Nutrition

de Batlle, J.; Ferrari, P.; Chajes, V.; Park, J. Y.; Slimani, N.; McKenzie, F.; Overvad, K.; Roswall, N.; Tjonneland, A. and Boutron-Ruault, M. C., et al. (2015) In Journal of the National Cancer Institute 107(1). p.367-367
Abstract
There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors. We investigated the relationship between dietary folate and BC risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 367993 women age 35 to 70 years were recruited in 10 European countries. During a median follow-up of 11.5 years, 11575 women with BC were identified. Dietary folate intake was estimated from country-specific dietary questionnaires. Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk. BC tumors were classified by receptor status. Subgroup analyses were... (More)
There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors. We investigated the relationship between dietary folate and BC risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 367993 women age 35 to 70 years were recruited in 10 European countries. During a median follow-up of 11.5 years, 11575 women with BC were identified. Dietary folate intake was estimated from country-specific dietary questionnaires. Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk. BC tumors were classified by receptor status. Subgroup analyses were performed by menopausal status and alcohol intake. Intake of other B vitamins was considered. All statistical tests were two-sided. A borderline inverse association was observed between dietary folate and BC risk (hazard ratio comparing top vs bottom quintile [HRQ5-Q1] = 0.92, 95% CI = 0.83 to 1.01, P (trend) = .037). In premenopausal women, we observed a statistically significant trend towards lower risk in estrogen receptor-negative BC (HRQ5-Q1 = 0.66, 95% CI = 0.45 to 0.96, P (trend) = .042) and progesterone receptor-negative BC (HRQ5-Q1 = 0.70, 95% CI = 0.51 to 0.97, P (trend) = .021). No associations were found in postmenopausal women. A 14% reduction in BC risk was observed when comparing the highest with the lowest dietary folate tertiles in women having a high (> 12 alcoholic drinks/week) alcohol intake (HRT3-T1 = 0.86, 95% CI = 0.75 to 0.98, P (interaction) = .035). Higher dietary folate intake may be associated with a lower risk of sex hormone receptor-negative BC in premenopausal women. (Less)
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Journal of the National Cancer Institute
volume
107
issue
1
pages
367 - 367
publisher
Oxford University Press
external identifiers
  • wos:000350232800018
  • scopus:84923898805
ISSN
1460-2105
DOI
10.1093/jnci/dju367
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English
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50cb1e76-f166-4984-87a0-3bf826c7f96f (old id 5303995)
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2015-05-04 08:36:43
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@article{50cb1e76-f166-4984-87a0-3bf826c7f96f,
  abstract     = {There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors. We investigated the relationship between dietary folate and BC risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 367993 women age 35 to 70 years were recruited in 10 European countries. During a median follow-up of 11.5 years, 11575 women with BC were identified. Dietary folate intake was estimated from country-specific dietary questionnaires. Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk. BC tumors were classified by receptor status. Subgroup analyses were performed by menopausal status and alcohol intake. Intake of other B vitamins was considered. All statistical tests were two-sided. A borderline inverse association was observed between dietary folate and BC risk (hazard ratio comparing top vs bottom quintile [HRQ5-Q1] = 0.92, 95% CI = 0.83 to 1.01, P (trend) = .037). In premenopausal women, we observed a statistically significant trend towards lower risk in estrogen receptor-negative BC (HRQ5-Q1 = 0.66, 95% CI = 0.45 to 0.96, P (trend) = .042) and progesterone receptor-negative BC (HRQ5-Q1 = 0.70, 95% CI = 0.51 to 0.97, P (trend) = .021). No associations were found in postmenopausal women. A 14% reduction in BC risk was observed when comparing the highest with the lowest dietary folate tertiles in women having a high (> 12 alcoholic drinks/week) alcohol intake (HRT3-T1 = 0.86, 95% CI = 0.75 to 0.98, P (interaction) = .035). Higher dietary folate intake may be associated with a lower risk of sex hormone receptor-negative BC in premenopausal women.},
  author       = {de Batlle, J. and Ferrari, P. and Chajes, V. and Park, J. Y. and Slimani, N. and McKenzie, F. and Overvad, K. and Roswall, N. and Tjonneland, A. and Boutron-Ruault, M. C. and Clavel-Chapelon, F. and Fagherazzi, G. and Katzke, V. and Kaaks, R. and Bergmann, M. M. and Trichopoulou, A. and Lagiou, P. and Trichopoulos, D. and Palli, D. and Sieri, S. and Panico, S. and Tumino, R. and Vineis, P. and Bueno-de-Mesquita, H. B. and Peeters, P. H. and Hjartaker, A. and Engeset, D. and Weiderpass, E. and Sanchez, S. and Travier, N. and Sanchez, M. J. and Amiano, P. and Chirlaque, M. D. and Barricarte Gurrea, A. and Khaw, K. T. and Key, T. J. and Bradbury, K. E. and Ericson, Ulrika and Sonestedt, Emily and Van Guelpen, B. and Schneede, J. and Riboli, E. and Romieu, I.},
  issn         = {1460-2105},
  language     = {eng},
  number       = {1},
  pages        = {367--367},
  publisher    = {Oxford University Press},
  series       = {Journal of the National Cancer Institute},
  title        = {Dietary Folate Intake and Breast Cancer Risk: European Prospective Investigation Into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1093/jnci/dju367},
  volume       = {107},
  year         = {2015},
}