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Total adiponectin in indigenous Melanesians on Kitava

Carrera-Bastos, Pedro LU ; Fontes-Villalba, Maelán LU orcid ; Ahrén, Bo LU ; Lindblad, Ulf LU ; Råstam, Lennart LU ; Frostegård, Johan ; Åkerfeldt, Torbjörn ; Granfeldt, Yvonne LU ; Sundquist, Kristina LU and Jönsson, Tommy LU (2024) In American Journal of Human Biology 36(10).
Abstract

Objectives: Experimental and small human studies have indicated that high total adiponectin levels have beneficial cardiometabolic effects. In contrast, however, high total adiponectin levels are also associated with higher all-cause and cardiovascular mortality in thoroughly adjusted epidemiological studies. To gain further insight into these seemingly contradictory results, we report results on total adiponectin from the indigenous Melanesian population of Kitava, Trobriand Islands, Papua New Guinea, where an apparent absence of cardiometabolic disease has been previously reported. Methods: Fasting levels of serum total adiponectin were measured cross-sectionally in ≥40-year-old Kitavans (n = 102) and Swedish controls matched for age... (More)

Objectives: Experimental and small human studies have indicated that high total adiponectin levels have beneficial cardiometabolic effects. In contrast, however, high total adiponectin levels are also associated with higher all-cause and cardiovascular mortality in thoroughly adjusted epidemiological studies. To gain further insight into these seemingly contradictory results, we report results on total adiponectin from the indigenous Melanesian population of Kitava, Trobriand Islands, Papua New Guinea, where an apparent absence of cardiometabolic disease has been previously reported. Methods: Fasting levels of serum total adiponectin were measured cross-sectionally in ≥40-year-old Kitavans (n = 102) and Swedish controls matched for age and sex (n = 108). Multivariable linear regression was used for the analysis of associations with total adiponectin when controlled for group, sex, smoking, hypertension and/or type 2 diabetes, age, and body mass index. Results: Total adiponectin was lower for Kitavans compared to Swedish controls (Median [Mdn] 4.6 μg/mL, range 1.0–206 μg/mL and Mdn 9.7 μg/mL, range 3.1–104 μg/mL, respectively, r =.64, p <.001). Lower total adiponectin was associated with Kitavan group, male sex (only in Swedish controls), smoking (only in Kitavans and Swedish controls combined), younger age (not in Swedish controls), higher BMI, lower total, low-density lipoprotein, high-density lipoprotein (HDL) (only in Kitavans and Swedish controls combined), and non-HDL cholesterol, and higher anti-PC IgG (only in Kitavans and Swedish controls combined). Conclusion: Total adiponectin in Kitavans was significantly lower than in Swedish controls.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Human Biology
volume
36
issue
10
article number
e24134
publisher
Wiley-Blackwell
external identifiers
  • pmid:38989782
  • scopus:85198119334
ISSN
1042-0533
DOI
10.1002/ajhb.24134
language
English
LU publication?
yes
id
53956b96-5de0-4be1-be7a-1175c8b8acb7
date added to LUP
2024-11-28 14:01:47
date last changed
2025-07-11 08:52:46
@article{53956b96-5de0-4be1-be7a-1175c8b8acb7,
  abstract     = {{<p>Objectives: Experimental and small human studies have indicated that high total adiponectin levels have beneficial cardiometabolic effects. In contrast, however, high total adiponectin levels are also associated with higher all-cause and cardiovascular mortality in thoroughly adjusted epidemiological studies. To gain further insight into these seemingly contradictory results, we report results on total adiponectin from the indigenous Melanesian population of Kitava, Trobriand Islands, Papua New Guinea, where an apparent absence of cardiometabolic disease has been previously reported. Methods: Fasting levels of serum total adiponectin were measured cross-sectionally in ≥40-year-old Kitavans (n = 102) and Swedish controls matched for age and sex (n = 108). Multivariable linear regression was used for the analysis of associations with total adiponectin when controlled for group, sex, smoking, hypertension and/or type 2 diabetes, age, and body mass index. Results: Total adiponectin was lower for Kitavans compared to Swedish controls (Median [Mdn] 4.6 μg/mL, range 1.0–206 μg/mL and Mdn 9.7 μg/mL, range 3.1–104 μg/mL, respectively, r =.64, p &lt;.001). Lower total adiponectin was associated with Kitavan group, male sex (only in Swedish controls), smoking (only in Kitavans and Swedish controls combined), younger age (not in Swedish controls), higher BMI, lower total, low-density lipoprotein, high-density lipoprotein (HDL) (only in Kitavans and Swedish controls combined), and non-HDL cholesterol, and higher anti-PC IgG (only in Kitavans and Swedish controls combined). Conclusion: Total adiponectin in Kitavans was significantly lower than in Swedish controls.</p>}},
  author       = {{Carrera-Bastos, Pedro and Fontes-Villalba, Maelán and Ahrén, Bo and Lindblad, Ulf and Råstam, Lennart and Frostegård, Johan and Åkerfeldt, Torbjörn and Granfeldt, Yvonne and Sundquist, Kristina and Jönsson, Tommy}},
  issn         = {{1042-0533}},
  language     = {{eng}},
  number       = {{10}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{American Journal of Human Biology}},
  title        = {{Total adiponectin in indigenous Melanesians on Kitava}},
  url          = {{http://dx.doi.org/10.1002/ajhb.24134}},
  doi          = {{10.1002/ajhb.24134}},
  volume       = {{36}},
  year         = {{2024}},
}