Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer's disease
(2024) In Alzheimer's Research & Therapy 16(1).- Abstract
BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfields and drivers of atrophy in amnestic EOAD is lacking.
METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β and tau-PET were included. Forty-one amnestic EOAD individuals ≤65 years and, as comparison, late-onset AD (aLOAD, ≥70 years, n = 154) and amyloid-β-negative cognitively unimpaired controls were included. MTL subregions and biomarkers of (co-)pathologies were measured.
RESULTS: AD groups showed smaller MTL subregions compared to controls. Atrophy patterns were similar across AD groups: aLOAD showed thinner entorhinal cortices than... (More)
BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfields and drivers of atrophy in amnestic EOAD is lacking.
METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β and tau-PET were included. Forty-one amnestic EOAD individuals ≤65 years and, as comparison, late-onset AD (aLOAD, ≥70 years, n = 154) and amyloid-β-negative cognitively unimpaired controls were included. MTL subregions and biomarkers of (co-)pathologies were measured.
RESULTS: AD groups showed smaller MTL subregions compared to controls. Atrophy patterns were similar across AD groups: aLOAD showed thinner entorhinal cortices than aEOAD; aEOAD showed thinner parietal regions than aLOAD. aEOAD showed lower white matter hyperintensities than aLOAD. No differences in MTL tau-PET or transactive response DNA binding protein 43-proxy positivity were found.
CONCLUSIONS: We found evidence for MTL atrophy in amnestic EOAD and overall similar levels to aLOAD of MTL tau pathology and co-pathologies.
(Less)
- author
- organization
-
- Clinical Memory Research (research group)
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- Department of Clinical Sciences, Malmö
- Diagnostic Radiology, (Lund)
- Department Office of Clinical Sciences, Malmö
- WCMM-Wallenberg Centre for Molecular Medicine
- eSSENCE: The e-Science Collaboration
- publishing date
- 2024-09-16
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Alzheimer Disease/pathology, Atrophy/pathology, Male, Female, Aged, Temporal Lobe/pathology, Middle Aged, Positron-Emission Tomography, Magnetic Resonance Imaging, tau Proteins/metabolism, Age of Onset, Amyloid beta-Peptides/metabolism, Amnesia/pathology, Aged, 80 and over, tau-PET imaging, Amyloid-beta, MRI, Medial temporal lobe subregions, aging, in vivo, Amnestic AD, Early-onset, late-onset, Amygdala segmentation protocol, TPD-43
- in
- Alzheimer's Research & Therapy
- volume
- 16
- issue
- 1
- article number
- 204
- pages
- 12 pages
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:39285454
- ISSN
- 1758-9193
- DOI
- 10.1186/s13195-024-01571-z
- language
- English
- LU publication?
- yes
- additional info
- © 2024. The Author(s).
- id
- 53fb429f-2f7b-4e69-9cdd-6ea9c3c0e129
- date added to LUP
- 2024-09-20 09:12:24
- date last changed
- 2024-09-20 10:35:09
@article{53fb429f-2f7b-4e69-9cdd-6ea9c3c0e129, abstract = {{<p>BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfields and drivers of atrophy in amnestic EOAD is lacking.</p><p>METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β and tau-PET were included. Forty-one amnestic EOAD individuals ≤65 years and, as comparison, late-onset AD (aLOAD, ≥70 years, n = 154) and amyloid-β-negative cognitively unimpaired controls were included. MTL subregions and biomarkers of (co-)pathologies were measured.</p><p>RESULTS: AD groups showed smaller MTL subregions compared to controls. Atrophy patterns were similar across AD groups: aLOAD showed thinner entorhinal cortices than aEOAD; aEOAD showed thinner parietal regions than aLOAD. aEOAD showed lower white matter hyperintensities than aLOAD. No differences in MTL tau-PET or transactive response DNA binding protein 43-proxy positivity were found.</p><p>CONCLUSIONS: We found evidence for MTL atrophy in amnestic EOAD and overall similar levels to aLOAD of MTL tau pathology and co-pathologies.</p>}}, author = {{Wuestefeld, Anika and Pichet Binette, Alexa and van Westen, Danielle and Strandberg, Olof and Stomrud, Erik and Mattsson-Carlgren, Niklas and Janelidze, Shorena and Smith, Ruben and Palmqvist, Sebastian and Baumeister, Hannah and Berron, David and Yushkevich, Paul A and Hansson, Oskar and Spotorno, Nicola and Wisse, Laura E M}}, issn = {{1758-9193}}, keywords = {{Humans; Alzheimer Disease/pathology; Atrophy/pathology; Male; Female; Aged; Temporal Lobe/pathology; Middle Aged; Positron-Emission Tomography; Magnetic Resonance Imaging; tau Proteins/metabolism; Age of Onset; Amyloid beta-Peptides/metabolism; Amnesia/pathology; Aged, 80 and over; tau-PET imaging; Amyloid-beta; MRI; Medial temporal lobe subregions; aging; in vivo; Amnestic AD; Early-onset; late-onset; Amygdala segmentation protocol; TPD-43}}, language = {{eng}}, month = {{09}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{Alzheimer's Research & Therapy}}, title = {{Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer's disease}}, url = {{http://dx.doi.org/10.1186/s13195-024-01571-z}}, doi = {{10.1186/s13195-024-01571-z}}, volume = {{16}}, year = {{2024}}, }