Advanced

Protocol for meta-analysis of temperature reduction in animal models of cardiac arrest

Olai, H; Thornéus, G; Watson, H; Macleod, Malcolm R; Friberg, H LU ; Rhodes, J R; Nielsen, N LU ; Cronberg, T LU and Deierborg, T LU (2016) In Evidence-based preclinical medicine 3(1). p.4-11
Abstract

Targeted temperature management (TTM) of 32-34 °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 showed benefits to survival and neurological outcome. Recently, this treatment has been challenged by another clinical trial showing no difference in outcome between TTM of 33 °C and 36 °C. This protocol describes the methodology for a meta-analysis detailing temperature-reducing interventions to treat global ischaemia in animal models. By combining relevant data sets in the literature, we will explore the experimental evidence for TTM. Our aims are to explain possible translational gaps and provide methodological considerations for future experimental research and clinical trials.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Journal Article
in
Evidence-based preclinical medicine
volume
3
issue
1
pages
4 - 11
ISSN
2054-703X
DOI
10.1002/ebm2.14
language
English
LU publication?
yes
id
5569199d-c6fe-473c-b9af-165a0a94526f
date added to LUP
2017-08-14 11:41:27
date last changed
2017-08-14 16:05:29
@article{5569199d-c6fe-473c-b9af-165a0a94526f,
  abstract     = {<p>Targeted temperature management (TTM) of 32-34 °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 showed benefits to survival and neurological outcome. Recently, this treatment has been challenged by another clinical trial showing no difference in outcome between TTM of 33 °C and 36 °C. This protocol describes the methodology for a meta-analysis detailing temperature-reducing interventions to treat global ischaemia in animal models. By combining relevant data sets in the literature, we will explore the experimental evidence for TTM. Our aims are to explain possible translational gaps and provide methodological considerations for future experimental research and clinical trials.</p>},
  articleno    = {e00014},
  author       = {Olai, H and Thornéus, G and Watson, H and Macleod, Malcolm R and Friberg, H and Rhodes, J R and Nielsen, N and Cronberg, T and Deierborg, T},
  issn         = {2054-703X},
  keyword      = {Journal Article},
  language     = {eng},
  number       = {1},
  pages        = {4--11},
  series       = {Evidence-based preclinical medicine},
  title        = {Protocol for meta-analysis of temperature reduction in animal models of cardiac arrest},
  url          = {http://dx.doi.org/10.1002/ebm2.14},
  volume       = {3},
  year         = {2016},
}