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Age-stratified comparison of prognosis in cardiac resynchronization therapy with or without prophylactic defibrillator for non-ischemic cardiomyopathy – a nationwide cohort study

Farouq, Maiwand LU ; Rorsman, Cecilia LU ; Marinko, Sofia LU ; Mörtsell, David LU orcid ; Chaudhry, Uzma LU ; Wang, Lingwei LU orcid ; Platonov, Pyotr LU and Borgquist, Rasmus LU orcid (2023) In Europace
Abstract
Background and aims
Prior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive Cardiac Resynchronization Therapy-defibrillator (CRT-D) or CRT-pacemaker (CRT-P).

Methods
All patients with non-ischemic cardiomyopathy and CRT-P or primary preventive CRT-D who were implanted in Sweden during the period 2005-2020 were included. Propensity scoring was used to create a matched cohort. Primary outcome was... (More)
Background and aims
Prior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive Cardiac Resynchronization Therapy-defibrillator (CRT-D) or CRT-pacemaker (CRT-P).

Methods
All patients with non-ischemic cardiomyopathy and CRT-P or primary preventive CRT-D who were implanted in Sweden during the period 2005-2020 were included. Propensity scoring was used to create a matched cohort. Primary outcome was all-cause mortality within five years.

Results
4027 patients were included, 2334 with CRT-P and 1693 with CRT-D. Crude 5-year mortality was 635 (27%) vs. 246 (15%), p 
Conclusion
In this nationwide registry-based study, patients with CRT-D have better five-year survival compared to patients with CRT-P. The interaction between age and mortality reduction not consistent, but patients with CRT-D aged (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Europace
article number
euad187
publisher
Oxford University Press
external identifiers
  • pmid:37392462
ISSN
1532-2092
DOI
10.1093/europace/euad187
language
English
LU publication?
yes
id
55a5a53c-b0e7-4eeb-a293-0f5dfdc76e19
date added to LUP
2023-06-06 17:03:44
date last changed
2023-10-04 03:00:17
@article{55a5a53c-b0e7-4eeb-a293-0f5dfdc76e19,
  abstract     = {{Background and aims<br/>Prior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive Cardiac Resynchronization Therapy-defibrillator (CRT-D) or CRT-pacemaker (CRT-P).<br/><br/>Methods<br/>All patients with non-ischemic cardiomyopathy and CRT-P or primary preventive CRT-D who were implanted in Sweden during the period 2005-2020 were included. Propensity scoring was used to create a matched cohort. Primary outcome was all-cause mortality within five years.<br/><br/>Results<br/>4027 patients were included, 2334 with CRT-P and 1693 with CRT-D. Crude 5-year mortality was 635 (27%) vs. 246 (15%), p <br/>Conclusion<br/>In this nationwide registry-based study, patients with CRT-D have better five-year survival compared to patients with CRT-P. The interaction between age and mortality reduction not consistent, but patients with CRT-D aged}},
  author       = {{Farouq, Maiwand and Rorsman, Cecilia and Marinko, Sofia and Mörtsell, David and Chaudhry, Uzma and Wang, Lingwei and Platonov, Pyotr and Borgquist, Rasmus}},
  issn         = {{1532-2092}},
  language     = {{eng}},
  month        = {{07}},
  publisher    = {{Oxford University Press}},
  series       = {{Europace}},
  title        = {{Age-stratified comparison of prognosis in cardiac resynchronization therapy with or without prophylactic defibrillator for non-ischemic cardiomyopathy – a nationwide cohort study}},
  url          = {{http://dx.doi.org/10.1093/europace/euad187}},
  doi          = {{10.1093/europace/euad187}},
  year         = {{2023}},
}