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Microchannel Acoustophoresis does not Impact Survival or Function of Microglia, Leukocytes or Tumor Cells.

Burguillos Garcia, Miguel LU ; Magnusson, Cecilia LU ; Nordin, Maria LU ; Lenshof, Andreas LU ; Augustsson, Per LU ; Hansson, Magnus LU orcid ; Elmer, Eskil LU orcid ; Lilja, Hans LU orcid ; Brundin, Patrik LU and Laurell, Thomas LU , et al. (2013) In PLoS ONE 8(5).
Abstract
The use of acoustic forces to manipulate particles or cells at the microfluidic scale (i.e. acoustophoresis), enables non-contact, label-free separation based on intrinsic cell properties such as size, density and compressibility. Acoustophoresis holds great promise as a cell separation technique in several research and clinical areas. However, it has been suggested that the force acting upon cells undergoing acoustophoresis may impact cell viability, proliferation or cell function via subtle phenotypic changes. If this were the case, it would suggest that the acoustophoresis method would be a less useful tool for many cell analysis applications as well as for cell therapy.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
8
issue
5
article number
e64233
publisher
Public Library of Science (PLoS)
external identifiers
  • wos:000319738100022
  • pmid:23724038
  • scopus:84878281766
  • pmid:23724038
ISSN
1932-6203
DOI
10.1371/journal.pone.0064233
language
English
LU publication?
yes
id
57b725b7-38e2-4460-a9c2-3b9705b5b825 (old id 3913833)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23724038?dopt=Abstract
date added to LUP
2016-04-01 13:04:33
date last changed
2024-01-09 06:49:14
@article{57b725b7-38e2-4460-a9c2-3b9705b5b825,
  abstract     = {{The use of acoustic forces to manipulate particles or cells at the microfluidic scale (i.e. acoustophoresis), enables non-contact, label-free separation based on intrinsic cell properties such as size, density and compressibility. Acoustophoresis holds great promise as a cell separation technique in several research and clinical areas. However, it has been suggested that the force acting upon cells undergoing acoustophoresis may impact cell viability, proliferation or cell function via subtle phenotypic changes. If this were the case, it would suggest that the acoustophoresis method would be a less useful tool for many cell analysis applications as well as for cell therapy.}},
  author       = {{Burguillos Garcia, Miguel and Magnusson, Cecilia and Nordin, Maria and Lenshof, Andreas and Augustsson, Per and Hansson, Magnus and Elmer, Eskil and Lilja, Hans and Brundin, Patrik and Laurell, Thomas and Deierborg, Tomas}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Microchannel Acoustophoresis does not Impact Survival or Function of Microglia, Leukocytes or Tumor Cells.}},
  url          = {{https://lup.lub.lu.se/search/files/3145369/4067568.pdf}},
  doi          = {{10.1371/journal.pone.0064233}},
  volume       = {{8}},
  year         = {{2013}},
}