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Microchannel Acoustophoresis does not Impact Survival or Function of Microglia, Leukocytes or Tumor Cells.

Burguillos Garcia, Miguel LU ; Magnusson, Cecilia LU ; Nordin, Maria LU ; Lenshof, Andreas LU ; Augustsson, Per LU ; Hansson, Magnus LU ; Elmer, Eskil LU ; Lilja, Hans LU ; Brundin, Patrik LU and Laurell, Thomas LU , et al. (2013) In PLoS ONE 8(5).
Abstract
The use of acoustic forces to manipulate particles or cells at the microfluidic scale (i.e. acoustophoresis), enables non-contact, label-free separation based on intrinsic cell properties such as size, density and compressibility. Acoustophoresis holds great promise as a cell separation technique in several research and clinical areas. However, it has been suggested that the force acting upon cells undergoing acoustophoresis may impact cell viability, proliferation or cell function via subtle phenotypic changes. If this were the case, it would suggest that the acoustophoresis method would be a less useful tool for many cell analysis applications as well as for cell therapy.
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publication status
published
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PLoS ONE
volume
8
issue
5
publisher
Public Library of Science
external identifiers
  • wos:000319738100022
  • pmid:23724038
  • scopus:84878281766
ISSN
1932-6203
DOI
language
English
LU publication?
yes
id
57b725b7-38e2-4460-a9c2-3b9705b5b825 (old id 3913833)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23724038?dopt=Abstract
date added to LUP
2013-07-01 10:28:07
date last changed
2018-06-24 04:00:08
@article{57b725b7-38e2-4460-a9c2-3b9705b5b825,
  abstract     = {The use of acoustic forces to manipulate particles or cells at the microfluidic scale (i.e. acoustophoresis), enables non-contact, label-free separation based on intrinsic cell properties such as size, density and compressibility. Acoustophoresis holds great promise as a cell separation technique in several research and clinical areas. However, it has been suggested that the force acting upon cells undergoing acoustophoresis may impact cell viability, proliferation or cell function via subtle phenotypic changes. If this were the case, it would suggest that the acoustophoresis method would be a less useful tool for many cell analysis applications as well as for cell therapy.},
  articleno    = {e64233},
  author       = {Burguillos Garcia, Miguel and Magnusson, Cecilia and Nordin, Maria and Lenshof, Andreas and Augustsson, Per and Hansson, Magnus and Elmer, Eskil and Lilja, Hans and Brundin, Patrik and Laurell, Thomas and Deierborg, Tomas},
  issn         = {1932-6203},
  language     = {eng},
  number       = {5},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Microchannel Acoustophoresis does not Impact Survival or Function of Microglia, Leukocytes or Tumor Cells.},
  url          = {http://dx.doi.org/},
  volume       = {8},
  year         = {2013},
}