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Consumption of fish is not associated with risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition (EPIC) study

Zamora-Ros, Raul; Castañeda, Jazmín; Rinaldi, Sabina; Cayssials, Valerie; Slimani, Nadia; Weiderpass, Elisabete; Tsilidis, Konstantinos K; Boutron-Ruault,, Marie-Christine; Overvad, Kim and Eriksen, Anne K., et al. (2017) In Journal of Nutrition 147(7). p.1366-1373
Abstract

Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk. Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: EPIC is a cohort of > 500,000 men and women, mostly aged 35-70 y, who were recruited in 10 European countries. After a mean follow-up of 14 y, 748 primary differentiated TC cases were diagnosed; 666 were in women and 601 were papillary TC. Data on intakes of lean fish, fatty fish, fish products,... (More)

Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk. Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: EPIC is a cohort of > 500,000 men and women, mostly aged 35-70 y, who were recruited in 10 European countries. After a mean follow-up of 14 y, 748 primary differentiated TC cases were diagnosed; 666 were in women and 601 were papillary TC. Data on intakes of lean fish, fatty fish, fish products, and shellfish were collected by using countryspecific validated dietary questionnaires at recruitment. Multivariable Cox regression was used to calculate HRs and 95% CIs adjusted for many potential confounders, including dietary and nondietary factors. Results: No significant association was observed between total fish consumption and differentiated TC risk for the highest compared with the lowest quartile (HR: 1.03; 95% CI: 0.81, 1.32; P-trend = 0.67). Likewise, no significant association was observed with the intake of any specific type of fish, fish product, or shellfish. No significant heterogeneity was found by TC subtype (papillary or follicular tumors), by sex, or between countries with low and high TC incidence. Conclusion: This large study shows that the intake of fish and shellfish was not associated with differentiated TC risk in Europe, a region in which iodine deficiency or excess is rare.

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published
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keywords
Cohort, EPIC, Fish, Intake, Thyroid cancer
in
Journal of Nutrition
volume
147
issue
7
pages
8 pages
publisher
American Society for Nutrition
external identifiers
  • scopus:85021716054
  • wos:000406533100018
ISSN
0022-3166
DOI
10.3945/jn.117.247874
language
English
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yes
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5a2f7f34-6471-41ca-bd23-71af8ba3df82
date added to LUP
2017-07-25 13:03:13
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2018-09-02 04:40:13
@article{5a2f7f34-6471-41ca-bd23-71af8ba3df82,
  abstract     = {<p>Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk. Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: EPIC is a cohort of &gt; 500,000 men and women, mostly aged 35-70 y, who were recruited in 10 European countries. After a mean follow-up of 14 y, 748 primary differentiated TC cases were diagnosed; 666 were in women and 601 were papillary TC. Data on intakes of lean fish, fatty fish, fish products, and shellfish were collected by using countryspecific validated dietary questionnaires at recruitment. Multivariable Cox regression was used to calculate HRs and 95% CIs adjusted for many potential confounders, including dietary and nondietary factors. Results: No significant association was observed between total fish consumption and differentiated TC risk for the highest compared with the lowest quartile (HR: 1.03; 95% CI: 0.81, 1.32; P-trend = 0.67). Likewise, no significant association was observed with the intake of any specific type of fish, fish product, or shellfish. No significant heterogeneity was found by TC subtype (papillary or follicular tumors), by sex, or between countries with low and high TC incidence. Conclusion: This large study shows that the intake of fish and shellfish was not associated with differentiated TC risk in Europe, a region in which iodine deficiency or excess is rare.</p>},
  author       = {Zamora-Ros, Raul and Castañeda, Jazmín and Rinaldi, Sabina and Cayssials, Valerie and Slimani, Nadia and Weiderpass, Elisabete and Tsilidis, Konstantinos K and Boutron-Ruault,, Marie-Christine and Overvad, Kim and Eriksen, Anne K. and Tjønneland, Anne and Kühn, Tilman and Katzke, Verena and Boeing, Heiner and Trichopoulou, Antonia and La Vecchia, Carlo and Kotanidou, Anastasia and Palli, Domenico and Grioni, Sara and Mattiello, Amalia and Tumino, Rosario and Sciannameo, Veronica and Lund, Eiliv and Merino, Susana and Salamanca-Fernández, Elena and Amiano, Pilar and Huerta, José María and Barricarte, Aurelio and Ericson, Ulrika and Almquist, Martin and Hennings, Joakim and Sandström, Maria and Bueno-De-Mesquita, Bas H. and Peeters, Petra H and Khaw, Kay Tee and Wareham, Nicholas J and Schmidt, Julie A. and Cross, Amanda J and Riboli, Elio and Scalbert, Augustin and Romieu, Isabelle and Agudo, Antonio and Franceschi, Silvia},
  issn         = {0022-3166},
  keyword      = {Cohort,EPIC,Fish,Intake,Thyroid cancer},
  language     = {eng},
  month        = {07},
  number       = {7},
  pages        = {1366--1373},
  publisher    = {American Society for Nutrition},
  series       = {Journal of Nutrition},
  title        = {Consumption of fish is not associated with risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition (EPIC) study},
  url          = {http://dx.doi.org/10.3945/jn.117.247874},
  volume       = {147},
  year         = {2017},
}