High-fat diet impairs hippocampal neurogenesis in male rats.
(2006) In European Journal of Neurology 13(12). p.1385-1388- Abstract
- High fat diets and obesity pose serious health problems, such as type II diabetes and cardiovascular disease. Impaired cognitive function is also associated with high fat intake. In this study, we show that just 4 weeks of feeding a diet rich in fat ad libitum decreased hippocampal neurogenesis in male, but not female, rats. There was no obesity, but male rats fed a diet rich in fat exhibited elevated serum corticosterone levels compared with those fed standard rat chow. These data indicate that high dietary fat intake can disrupt hippocampal neurogenesis, probably through an increase in serum corticosterone levels, and that males are more susceptible than females.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/163110
- author
- Lindqvist, Andreas LU ; Mohapel, Paul LU ; Bouter, B ; Frielingsdorf, Helena LU ; Pizzo, D ; Brundin, Patrik LU and Erlanson-Albertsson, Charlotte LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- fat intake, obesity, memory, hippocampus, corticosterone
- in
- European Journal of Neurology
- volume
- 13
- issue
- 12
- pages
- 1385 - 1388
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000241953100024
- scopus:33750948034
- ISSN
- 1351-5101
- DOI
- 10.1111/j.1468-1331.2006.01500.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuroendocrine Cell Biology (013241501), Endocrinology (013241500), Neuronal Survival (013212041), Apetite Regulation (013212030), Wallenberg Neuroscience Centre, Lund (0131000110)
- id
- 5bbf20b1-d302-45b3-a6c2-f7b5f78bd0bb (old id 163110)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17116226&dopt=Abstract
- date added to LUP
- 2016-04-01 11:48:48
- date last changed
- 2022-04-20 22:08:59
@article{5bbf20b1-d302-45b3-a6c2-f7b5f78bd0bb, abstract = {{High fat diets and obesity pose serious health problems, such as type II diabetes and cardiovascular disease. Impaired cognitive function is also associated with high fat intake. In this study, we show that just 4 weeks of feeding a diet rich in fat ad libitum decreased hippocampal neurogenesis in male, but not female, rats. There was no obesity, but male rats fed a diet rich in fat exhibited elevated serum corticosterone levels compared with those fed standard rat chow. These data indicate that high dietary fat intake can disrupt hippocampal neurogenesis, probably through an increase in serum corticosterone levels, and that males are more susceptible than females.}}, author = {{Lindqvist, Andreas and Mohapel, Paul and Bouter, B and Frielingsdorf, Helena and Pizzo, D and Brundin, Patrik and Erlanson-Albertsson, Charlotte}}, issn = {{1351-5101}}, keywords = {{fat intake; obesity; memory; hippocampus; corticosterone}}, language = {{eng}}, number = {{12}}, pages = {{1385--1388}}, publisher = {{Wiley-Blackwell}}, series = {{European Journal of Neurology}}, title = {{High-fat diet impairs hippocampal neurogenesis in male rats.}}, url = {{https://lup.lub.lu.se/search/files/2653075/625751.pdf}}, doi = {{10.1111/j.1468-1331.2006.01500.x}}, volume = {{13}}, year = {{2006}}, }