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A longer interstimulus interval yields better learning in adults and young adolescents

Kjell, Katarina LU ; Löwgren, Karolina LU and Rasmussen, Anders LU (2018) In Frontiers in Behavioral Neuroscience 12.
Abstract

Eyeblink conditioning is one of the most popular experimental paradigms for studying the neural mechanisms underlying learning and memory. A key parameter in eyeblink conditioning is the interstimulus interval (ISI), the time between the onset of the conditional stimulus (CS) and the onset of the unconditional stimulus (US). Though previous studies have examined how the ISI affects learning there is no clear consensus concerning which ISI is most effective and different researchers use different ISIs. Importantly, the brain undergoes changes throughout life with significant cerebellar growth in adolescents, which could mean that different ISIs might be called for in children, adolescents and adults. Moreover, the fact that animals are... (More)

Eyeblink conditioning is one of the most popular experimental paradigms for studying the neural mechanisms underlying learning and memory. A key parameter in eyeblink conditioning is the interstimulus interval (ISI), the time between the onset of the conditional stimulus (CS) and the onset of the unconditional stimulus (US). Though previous studies have examined how the ISI affects learning there is no clear consensus concerning which ISI is most effective and different researchers use different ISIs. Importantly, the brain undergoes changes throughout life with significant cerebellar growth in adolescents, which could mean that different ISIs might be called for in children, adolescents and adults. Moreover, the fact that animals are often trained with a shorter ISI than humans make direct comparisons problematic. In this study, we compared eyeblink conditioning in young adolescents aged 10–15 and adults using one short ISI (300 ms) and one long ISI (500 ms). The results demonstrate that young adolescents and adults produce a higher percentage of CRs when they are trained with a 500 ms ISI compared to a 300 ms ISI. The results also show that learning is better in the adults, especially for the shorter ISI.

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organization
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Contribution to journal
publication status
published
subject
keywords
Adolescent, Cerebellum, Classical conditioning, Comparative analaysis, Eyeblink conditioning, Interstimulus interval (ISI), Motor learning, Timing
in
Frontiers in Behavioral Neuroscience
volume
12
article number
299
publisher
Frontiers
external identifiers
  • scopus:85058969178
  • pmid:30559655
ISSN
1662-5153
DOI
10.3389/fnbeh.2018.00299
language
English
LU publication?
yes
id
5debc14e-3dc4-48d8-b371-8e4feb20d5b1
date added to LUP
2019-01-03 13:34:11
date last changed
2019-11-25 09:26:28
@article{5debc14e-3dc4-48d8-b371-8e4feb20d5b1,
  abstract     = {<p>Eyeblink conditioning is one of the most popular experimental paradigms for studying the neural mechanisms underlying learning and memory. A key parameter in eyeblink conditioning is the interstimulus interval (ISI), the time between the onset of the conditional stimulus (CS) and the onset of the unconditional stimulus (US). Though previous studies have examined how the ISI affects learning there is no clear consensus concerning which ISI is most effective and different researchers use different ISIs. Importantly, the brain undergoes changes throughout life with significant cerebellar growth in adolescents, which could mean that different ISIs might be called for in children, adolescents and adults. Moreover, the fact that animals are often trained with a shorter ISI than humans make direct comparisons problematic. In this study, we compared eyeblink conditioning in young adolescents aged 10–15 and adults using one short ISI (300 ms) and one long ISI (500 ms). The results demonstrate that young adolescents and adults produce a higher percentage of CRs when they are trained with a 500 ms ISI compared to a 300 ms ISI. The results also show that learning is better in the adults, especially for the shorter ISI.</p>},
  author       = {Kjell, Katarina and Löwgren, Karolina and Rasmussen, Anders},
  issn         = {1662-5153},
  language     = {eng},
  month        = {12},
  publisher    = {Frontiers},
  series       = {Frontiers in Behavioral Neuroscience},
  title        = {A longer interstimulus interval yields better learning in adults and young adolescents},
  url          = {http://dx.doi.org/10.3389/fnbeh.2018.00299},
  doi          = {10.3389/fnbeh.2018.00299},
  volume       = {12},
  year         = {2018},
}