Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics
(2023) In Science (New York, N.Y.) 379(6634). p.795-802- Abstract
Interfacing electronics with neural tissue is crucial for understanding complex biological functions, but conventional bioelectronics consist of rigid electrodes fundamentally incompatible with living systems. The difference between static solid-state electronics and dynamic biological matter makes seamless integration of the two challenging. To address this incompatibility, we developed a method to dynamically create soft substrate-free conducting materials within the biological environment. We demonstrate in vivo electrode formation in zebrafish and leech models, using endogenous metabolites to trigger enzymatic polymerization of organic precursors within an injectable gel, thereby forming conducting polymer gels with long-range... (More)
Interfacing electronics with neural tissue is crucial for understanding complex biological functions, but conventional bioelectronics consist of rigid electrodes fundamentally incompatible with living systems. The difference between static solid-state electronics and dynamic biological matter makes seamless integration of the two challenging. To address this incompatibility, we developed a method to dynamically create soft substrate-free conducting materials within the biological environment. We demonstrate in vivo electrode formation in zebrafish and leech models, using endogenous metabolites to trigger enzymatic polymerization of organic precursors within an injectable gel, thereby forming conducting polymer gels with long-range conductivity. This approach can be used to target specific biological substructures and is suitable for nerve stimulation, paving the way for fully integrated, in vivo-fabricated electronics within the nervous system.
(Less)
- author
- organization
-
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- Chemical Biology and Therapeutics (research group)
- LU Profile Area: Light and Materials
- LTH Profile Area: Nanoscience and Semiconductor Technology
- NanoLund: Centre for Nanoscience
- Centre for Analysis and Synthesis
- LUCC: Lund University Cancer Centre
- publishing date
- 2023-02-24
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Science (New York, N.Y.)
- volume
- 379
- issue
- 6634
- pages
- 795 - 802
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- scopus:85148681544
- pmid:36821679
- ISSN
- 1095-9203
- DOI
- 10.1126/science.adc9998
- language
- English
- LU publication?
- yes
- id
- 60978584-39dc-4030-a013-49a180fe2477
- alternative location
- https://www.science.org/doi/10.1126/science.adc9998?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
- date added to LUP
- 2023-02-27 08:52:34
- date last changed
- 2024-09-19 16:45:04
@article{60978584-39dc-4030-a013-49a180fe2477, abstract = {{<p>Interfacing electronics with neural tissue is crucial for understanding complex biological functions, but conventional bioelectronics consist of rigid electrodes fundamentally incompatible with living systems. The difference between static solid-state electronics and dynamic biological matter makes seamless integration of the two challenging. To address this incompatibility, we developed a method to dynamically create soft substrate-free conducting materials within the biological environment. We demonstrate in vivo electrode formation in zebrafish and leech models, using endogenous metabolites to trigger enzymatic polymerization of organic precursors within an injectable gel, thereby forming conducting polymer gels with long-range conductivity. This approach can be used to target specific biological substructures and is suitable for nerve stimulation, paving the way for fully integrated, in vivo-fabricated electronics within the nervous system.</p>}}, author = {{Strakosas, Xenofon and Biesmans, Hanne and Abrahamsson, Tobias and Hellman, Karin and Ejneby, Malin Silverå and Donahue, Mary J and Ekström, Peter and Ek, Fredrik and Savvakis, Marios and Hjort, Martin and Bliman, David and Linares, Mathieu and Lindholm, Caroline and Stavrinidou, Eleni and Gerasimov, Jennifer Y and Simon, Daniel T and Olsson, Roger and Berggren, Magnus}}, issn = {{1095-9203}}, language = {{eng}}, month = {{02}}, number = {{6634}}, pages = {{795--802}}, publisher = {{American Association for the Advancement of Science (AAAS)}}, series = {{Science (New York, N.Y.)}}, title = {{Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics}}, url = {{http://dx.doi.org/10.1126/science.adc9998}}, doi = {{10.1126/science.adc9998}}, volume = {{379}}, year = {{2023}}, }