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Pharmacokinetic study of a systemically administered novel liposomal Temoporfin formulation in an animal tumor model

Svensson, Jenny LU ; Johansson, Ann LU ; Bendsöe, Niels LU ; Grafe, Susanna ; Trebst, Tilmann ; Andersson-Engels, Stefan LU and Svanberg, Katarina LU (2007) Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI 6427. p.4270-4270
Abstract
Meso-tetra(hydroxyphenyl)chlorin (mTHPC) (international generic name Temoporfin) is a potent photosensitizer used for photodynamic therapy (PDT). In this study the pharmacokinetics of a systemically administered novel lipid formulation of Temoporfin in a murine tumor model has been investigated. Fluorescence spectroscopy measurements were performed at several time intervals following drug administration, yielding information on the Temoporfin concentration within excised internal organs as a function of time after injection. Both point-monitoring and imaging setups were used. The acquired fluorescence data were correlated to the concentration of Temoporfin obtained with High Performance Liquid Chromatography (HPLC). There was a significant... (More)
Meso-tetra(hydroxyphenyl)chlorin (mTHPC) (international generic name Temoporfin) is a potent photosensitizer used for photodynamic therapy (PDT). In this study the pharmacokinetics of a systemically administered novel lipid formulation of Temoporfin in a murine tumor model has been investigated. Fluorescence spectroscopy measurements were performed at several time intervals following drug administration, yielding information on the Temoporfin concentration within excised internal organs as a function of time after injection. Both point-monitoring and imaging setups were used. The acquired fluorescence data were correlated to the concentration of Temoporfin obtained with High Performance Liquid Chromatography (HPLC). There was a significant correlation between the fluorescence methods and HPLC for most organs investigated. The pharmacokinetics of this new liposomal formulation of Temoporfin exhibited a rather flat temporal profile in the time interval 2-8 hours in this study. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Flat temporal profile, Temoporfin, Liposomal formulation
host publication
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
volume
6427
pages
4270 - 4270
publisher
SPIE
conference name
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI
conference location
San Jose, CA, United States
conference dates
2007-01-20 - 2007-01-21
external identifiers
  • wos:000246489700020
  • scopus:34548238711
ISSN
1042-4687
1605-7422
DOI
10.1117/12.698932
language
English
LU publication?
yes
id
0f3c79a1-f3cd-4147-bd94-dc85e9dd199f (old id 643404)
date added to LUP
2016-04-01 12:24:49
date last changed
2021-03-16 04:37:33
@inproceedings{0f3c79a1-f3cd-4147-bd94-dc85e9dd199f,
  abstract     = {Meso-tetra(hydroxyphenyl)chlorin (mTHPC) (international generic name Temoporfin) is a potent photosensitizer used for photodynamic therapy (PDT). In this study the pharmacokinetics of a systemically administered novel lipid formulation of Temoporfin in a murine tumor model has been investigated. Fluorescence spectroscopy measurements were performed at several time intervals following drug administration, yielding information on the Temoporfin concentration within excised internal organs as a function of time after injection. Both point-monitoring and imaging setups were used. The acquired fluorescence data were correlated to the concentration of Temoporfin obtained with High Performance Liquid Chromatography (HPLC). There was a significant correlation between the fluorescence methods and HPLC for most organs investigated. The pharmacokinetics of this new liposomal formulation of Temoporfin exhibited a rather flat temporal profile in the time interval 2-8 hours in this study.},
  author       = {Svensson, Jenny and Johansson, Ann and Bendsöe, Niels and Grafe, Susanna and Trebst, Tilmann and Andersson-Engels, Stefan and Svanberg, Katarina},
  booktitle    = {Progress in Biomedical Optics and Imaging - Proceedings of SPIE},
  issn         = {1042-4687},
  language     = {eng},
  pages        = {4270--4270},
  publisher    = {SPIE},
  title        = {Pharmacokinetic study of a systemically administered novel liposomal Temoporfin formulation in an animal tumor model},
  url          = {https://lup.lub.lu.se/search/ws/files/2913011/2370797.pdf},
  doi          = {10.1117/12.698932},
  volume       = {6427},
  year         = {2007},
}