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Physical inactivity increases the risk of endometrial cancer and premenopausal breast cancer

A., Johnsson LU ; P., Broberg LU ; Å, Tornberg LU and H., Olsson LU (2015) American Association for Cancer Research (AACR) 106th Annual Meeting 2015 In Cancer Research 75(15 Suppl).
Abstract
Background. Epidemiological studies indicate that physical activity reduces the risk of cancer. Physical inactivity or sedentary behavior, has recently been suggested as a risk factor independent of physical activity level. Breast and endometrial cancer incidence have both been associated with physical activity, and endometrial cancer incidence with physical inactivity/sedentary behavior. The purpose of the present study was to investigate physical inactivity as a risk factor for breast cancer, divided into pre- and postmenopausal subtypes, and for endometrial cancer, and to explore possible dose-response relations regarding the level of physical inactivity. Methods. In a population-based prospective cohort study, 29 520 women in the... (More)
Background. Epidemiological studies indicate that physical activity reduces the risk of cancer. Physical inactivity or sedentary behavior, has recently been suggested as a risk factor independent of physical activity level. Breast and endometrial cancer incidence have both been associated with physical activity, and endometrial cancer incidence with physical inactivity/sedentary behavior. The purpose of the present study was to investigate physical inactivity as a risk factor for breast cancer, divided into pre- and postmenopausal subtypes, and for endometrial cancer, and to explore possible dose-response relations regarding the level of physical inactivity. Methods. In a population-based prospective cohort study, 29 520 women in the southern part of Sweden, in ages between 25 and 64 years, participated. A questionnaire-based survey was performed 1990-92. Their reported professions were classified as sedentary or not which together with reported participation in competitive sports constituted the basis for classification into three activity-levels; (1) physical inactivity, defined as having sedentary occupation and no participation in competitive sports, (2) partly inactive, defined as either having a sedentary occupation or non- participation in competitive sports, (3) Physical active, defined as not having a sedentary occupation and participation in competitive sports. The association between physical inactivity and pre and postmenopausal breast and endometrial cancer incidence were analyzed by Cox regression, adjusted for hormonal factors, family history of cancer, body mass index (BMI) and age. Results. Physical inactive women had a significantly increased risk of endometrial cancer (HR = 2.41, 95% CI 1.14-5.11) and premenopausal breast cancer (HR = 2.40, 95% CI 1.14-5.02), compared with women who were less physical inactive. No such association was found for postmenopausal breast cancer. Analysis of linear trend showed a significant dose-response relationship with increased risk of both premenopausal breast cancer (ptrend 0.02) and endometrial cancer (ptrend (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
risk, endometrium cancer, breast cancer, American, cancer research, physical inactivity, physical activity, sport, occupation, human, female, cancer incidence, dose response, breast, neoplasm, risk factor, body mass, family history, proportional hazards model, classification, questionnaire, Sweden, cohort analysis, population
in
Cancer Research
volume
75
issue
15 Suppl
article number
Abstract 865
publisher
American Association for Cancer Research Inc.
conference name
American Association for Cancer Research (AACR) 106th Annual Meeting 2015
conference location
Philadelphia, United States
conference dates
2015-04-18 - 2015-04-22
ISSN
0008-5472
DOI
10.1158/1538-7445.AM2015-865
language
English
LU publication?
yes
id
65b426d2-423c-4ced-836a-f69418f127ef
date added to LUP
2019-07-01 11:23:40
date last changed
2019-07-01 11:23:40
@misc{65b426d2-423c-4ced-836a-f69418f127ef,
  abstract     = {Background. Epidemiological studies indicate that physical activity reduces the risk of cancer. Physical inactivity or sedentary behavior, has recently been suggested as a risk factor independent of physical activity level. Breast and endometrial cancer incidence have both been associated with physical activity, and endometrial cancer incidence with physical inactivity/sedentary behavior. The purpose of the present study was to investigate physical inactivity as a risk factor for breast cancer, divided into pre- and postmenopausal subtypes, and for endometrial cancer, and to explore possible dose-response relations regarding the level of physical inactivity. Methods. In a population-based prospective cohort study, 29 520 women in the southern part of Sweden, in ages between 25 and 64 years, participated. A questionnaire-based survey was performed 1990-92. Their reported professions were classified as sedentary or not which together with reported participation in competitive sports constituted the basis for classification into three activity-levels; (1) physical inactivity, defined as having sedentary occupation and no participation in competitive sports, (2) partly inactive, defined as either having a sedentary occupation or non- participation in competitive sports, (3) Physical active, defined as not having a sedentary occupation and participation in competitive sports. The association between physical inactivity and pre and postmenopausal breast and endometrial cancer incidence were analyzed by Cox regression, adjusted for hormonal factors, family history of cancer, body mass index (BMI) and age. Results. Physical inactive women had a significantly increased risk of endometrial cancer (HR = 2.41, 95% CI 1.14-5.11) and premenopausal breast cancer (HR = 2.40, 95% CI 1.14-5.02), compared with women who were less physical inactive. No such association was found for postmenopausal breast cancer. Analysis of linear trend showed a significant dose-response relationship with increased risk of both premenopausal breast cancer (ptrend 0.02) and endometrial cancer (ptrend },
  author       = {A., Johnsson and P., Broberg and Å, Tornberg and H., Olsson},
  issn         = {0008-5472},
  language     = {eng},
  note         = {Conference Abstract},
  number       = {15 Suppl},
  publisher    = {American Association for Cancer Research Inc.},
  series       = {Cancer Research},
  title        = {Physical inactivity increases the risk of endometrial cancer and premenopausal breast cancer},
  url          = {http://dx.doi.org/10.1158/1538-7445.AM2015-865},
  doi          = {10.1158/1538-7445.AM2015-865},
  volume       = {75},
  year         = {2015},
}