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Alcohol intake and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC)

Tjonneland, Anne; Christensen, Jane; Olsen, Anja; Stripp, Connie; Thomsen, Birthe L.; Overvad, Kim; Peeters, Petra H. M.; van Gils, Carla H.; Bueno-de-Mesquita, H. Bas and Ocke, Marga C., et al. (2007) In Cancer Causes and Control 18(4). p.361-373
Abstract
Objective Most epidemiologic studies have suggested an increased risk of breast cancer with increasing alcohol intake. Using data from 274,688 women participating in the European Prospective Investigation into Cancer and Nutrition study (EPIC), we investigated the relation between alcohol intake and the risk of breast cancer. Methods Incidence rate ratios (IRRs) based on Cox proportional hazard models were calculated using reported intake of alcohol, recent (at baseline) and lifetime exposure. We adjusted for known risk factors and stratified according to study center as well as potentially modifying host factors. Results During 6.4 years of follow up, 4,285 invasive cases of breast cancer within the age group 35-75 years were identified.... (More)
Objective Most epidemiologic studies have suggested an increased risk of breast cancer with increasing alcohol intake. Using data from 274,688 women participating in the European Prospective Investigation into Cancer and Nutrition study (EPIC), we investigated the relation between alcohol intake and the risk of breast cancer. Methods Incidence rate ratios (IRRs) based on Cox proportional hazard models were calculated using reported intake of alcohol, recent (at baseline) and lifetime exposure. We adjusted for known risk factors and stratified according to study center as well as potentially modifying host factors. Results During 6.4 years of follow up, 4,285 invasive cases of breast cancer within the age group 35-75 years were identified. For all countries together the IRR per 10 g/day higher recent alcohol intake (continuous) was 1.03 (95% confidence interval (CI): 1.01-1.05). When adjusted, no association was seen between lifetime alcohol intake and risk of breast cancer. No difference in risk was shown between users and non-users of HRT, and there was no significant interaction between alcohol intake and BMI, HRT or dietary folate. Conclusion This large European study supports previous findings that recent alcohol intake increases the risk of breast cancer. (Less)
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Contribution to journal
publication status
published
subject
keywords
hormone replacement therapy, cohort study, alcohol, breast neoplasm
in
Cancer Causes and Control
volume
18
issue
4
pages
361 - 373
publisher
Springer
external identifiers
  • wos:000244993900003
  • scopus:33947251938
ISSN
1573-7225
DOI
10.1007/s10552-006-0112-9
language
English
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yes
id
aecfd2ac-dda3-40a1-81ef-5f14d37ffb3d (old id 670187)
date added to LUP
2007-12-19 09:47:53
date last changed
2017-09-10 03:38:47
@article{aecfd2ac-dda3-40a1-81ef-5f14d37ffb3d,
  abstract     = {Objective Most epidemiologic studies have suggested an increased risk of breast cancer with increasing alcohol intake. Using data from 274,688 women participating in the European Prospective Investigation into Cancer and Nutrition study (EPIC), we investigated the relation between alcohol intake and the risk of breast cancer. Methods Incidence rate ratios (IRRs) based on Cox proportional hazard models were calculated using reported intake of alcohol, recent (at baseline) and lifetime exposure. We adjusted for known risk factors and stratified according to study center as well as potentially modifying host factors. Results During 6.4 years of follow up, 4,285 invasive cases of breast cancer within the age group 35-75 years were identified. For all countries together the IRR per 10 g/day higher recent alcohol intake (continuous) was 1.03 (95% confidence interval (CI): 1.01-1.05). When adjusted, no association was seen between lifetime alcohol intake and risk of breast cancer. No difference in risk was shown between users and non-users of HRT, and there was no significant interaction between alcohol intake and BMI, HRT or dietary folate. Conclusion This large European study supports previous findings that recent alcohol intake increases the risk of breast cancer.},
  author       = {Tjonneland, Anne and Christensen, Jane and Olsen, Anja and Stripp, Connie and Thomsen, Birthe L. and Overvad, Kim and Peeters, Petra H. M. and van Gils, Carla H. and Bueno-de-Mesquita, H. Bas and Ocke, Marga C. and Thiebaut, Anne and Fournier, Agne S. and Clavel-Chapelon, Francoise and Berrino, Franco and Palli, Domenico and Tumino, Rosario and Panico, Salvatore and Vineis, Paolo and Agudo, Antonio and Ardanaz, Eva and Martinez-Garcia, Carmen and Amiano, Pilar and Navarro, Carmen and Quiros, Jose R. and Key, Tim J. and Reeves, Gillian and Khaw, Kay-Tee and Bingham, Sheila and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Naska, Androniki and Nagel, Gabriele and Chang-Claude, Jenny and Boeing, Heiner and Lahmann, Petra H. and Manjer, Jonas and Wirfält, Elisabet and Hallmans, Goran and Johansson, Ingegerd and Lund, Eiliv and Skeie, Guri and Hjartaker, Anette and Ferrari, Pietro and Slimani, Nadia and Kaaks, Rudolf and Riboli, Elio},
  issn         = {1573-7225},
  keyword      = {hormone replacement therapy,cohort study,alcohol,breast neoplasm},
  language     = {eng},
  number       = {4},
  pages        = {361--373},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Alcohol intake and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1007/s10552-006-0112-9},
  volume       = {18},
  year         = {2007},
}