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Fruit and vegetable consumption and lung cancer risk: Updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Linseisen, Jakob; Rohrmann, Sabine; Miller, Anthony B.; Bueno-de-Mesquita, H. Bas; Buechner, Frederike L.; Vineis, Paolo; Agudo, Antonio; Gram, Inger T.; Janson, Lars and Krogh, Vittorio, et al. (2007) In International Journal of Cancer 121(5). p.1103-1114
Abstract
The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food frequency questionnaire data. Between 1992 and 2000, detailed information on diet and life-style of 478,590 individuals participating in EPIC was collected. During a median follow-up of 6.4 years, 1,126 lung cancer cases were observed. Multivariate Cox proportional hazard models were applied for statistical evaluation. In the whole study population, fruit consumption was significantly inversely associated with lung cancer... (More)
The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food frequency questionnaire data. Between 1992 and 2000, detailed information on diet and life-style of 478,590 individuals participating in EPIC was collected. During a median follow-up of 6.4 years, 1,126 lung cancer cases were observed. Multivariate Cox proportional hazard models were applied for statistical evaluation. In the whole study population, fruit consumption was significantly inversely associated with lung cancer risk while no association was found for vegetable consumption. In current smokers, however, lung cancer risk significantly decreased with higher vegetable consumption; this association became more pronounced after calibration, the hazard ratio (HR) being 0.78 (95% CI 0.620.98) per 100 g increase in daily vegetable consumption. In comparison, the HR per 100 g fruit was 0.92 (0.85-0.99) in the entire cohort and 0.90 (0.81-0.99) in smokers. Exclusion of cases diagnosed during the first 2 years of follow-up strengthened these associations, the HR being 0.71 (0.55-0.94) for vegetables (smokers) and 0.86 (0.78-0.95) for fruit (entire cohort). Cancer incidence decreased with higher consumption of apples and pears (entire cohort) as well as root vegetables (smokers). In addition to an overall inverse association with fruit intake, the results of this evaluation add evidence for a significant inverse association of vegetable consumption and lung cancer incidence in smokers. (C) 2007 Wiley-Liss, Inc. (Less)
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Contribution to journal
publication status
published
subject
keywords
smoking, lung cancer, vegetables, fruit, epidemiology, cancer, diet
in
International Journal of Cancer
volume
121
issue
5
pages
1103 - 1114
publisher
John Wiley & Sons
external identifiers
  • wos:000248242500024
  • scopus:34547124322
ISSN
0020-7136
DOI
10.1002/ijc.22807
language
English
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yes
id
25571c27-b1b0-470e-bdcf-609aa716ae61 (old id 691857)
date added to LUP
2007-12-13 08:22:01
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2017-11-05 03:28:14
@article{25571c27-b1b0-470e-bdcf-609aa716ae61,
  abstract     = {The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food frequency questionnaire data. Between 1992 and 2000, detailed information on diet and life-style of 478,590 individuals participating in EPIC was collected. During a median follow-up of 6.4 years, 1,126 lung cancer cases were observed. Multivariate Cox proportional hazard models were applied for statistical evaluation. In the whole study population, fruit consumption was significantly inversely associated with lung cancer risk while no association was found for vegetable consumption. In current smokers, however, lung cancer risk significantly decreased with higher vegetable consumption; this association became more pronounced after calibration, the hazard ratio (HR) being 0.78 (95% CI 0.620.98) per 100 g increase in daily vegetable consumption. In comparison, the HR per 100 g fruit was 0.92 (0.85-0.99) in the entire cohort and 0.90 (0.81-0.99) in smokers. Exclusion of cases diagnosed during the first 2 years of follow-up strengthened these associations, the HR being 0.71 (0.55-0.94) for vegetables (smokers) and 0.86 (0.78-0.95) for fruit (entire cohort). Cancer incidence decreased with higher consumption of apples and pears (entire cohort) as well as root vegetables (smokers). In addition to an overall inverse association with fruit intake, the results of this evaluation add evidence for a significant inverse association of vegetable consumption and lung cancer incidence in smokers. (C) 2007 Wiley-Liss, Inc.},
  author       = {Linseisen, Jakob and Rohrmann, Sabine and Miller, Anthony B. and Bueno-de-Mesquita, H. Bas and Buechner, Frederike L. and Vineis, Paolo and Agudo, Antonio and Gram, Inger T. and Janson, Lars and Krogh, Vittorio and Overvad, Kim and Rasmuson, Torgny and Schulz, Mandy and Pischon, Tobias and Kaaks, Rudolf and Nieters, Alexandra and Allen, Naomi E. and Key, Timothy J. and Bingham, Sheila and Khaw, Kay-Tee and Amiano, Pilar and Barricarte, Aurelio and Martinez, Carmen and Navarro, Carmen and Quiros, Ramon and Clavel-Charelon, Fran Oise and Boutron-Ruault, Marie-Christine and Touvier, Mathilde and Peeters, Petra H. M. and Berglund, Göran and Hallmans, Goran and Lund, Eiliv and Palli, Domenico and Panico, Salvatore and Tumino, Rosario and Tjonneland, Anne and Olsen, Anja and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Autier, Philippe and Boffetta, Paolo and Slimani, Nadia and Riboli, Elio},
  issn         = {0020-7136},
  keyword      = {smoking,lung cancer,vegetables,fruit,epidemiology,cancer,diet},
  language     = {eng},
  number       = {5},
  pages        = {1103--1114},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Fruit and vegetable consumption and lung cancer risk: Updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1002/ijc.22807},
  volume       = {121},
  year         = {2007},
}