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Nothing but NETs : Cytokine adsorption correlates with lower circulating nucleosomes and is associated with decreased primary graft dysfunction

Lindstedt, Sandra LU ; Niroomand, Anna LU ; Mittendorfer, Margareta LU ; Hirdman, Gabriel LU ; Hyllén, Snejana LU ; Pierre, Leif LU and Olm, Franziska LU orcid (2023) In The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 42(10). p.1358-1362
Abstract

Elevated levels of neutrophil extracellular traps (NETs) have been reported in primary graft dysfunction, making methods to reduce or remove them highly valuable. The mechanisms behind primary graft dysfunction remain rudimentarily understood but its relation to higher rates of acute and chronic rejection necessitates the development of preventative treatments. This case series explores the use of a cytokine adsorber during lung transplantation with the focus of reducing circulating nucleosome levels as a measure of neutrophil extracellular traps. Treated patients showed reduced levels of circulating nucleosomes and remained free from primary graft dysfunction and histopathological signs of acute rejection at 1-and 3-month... (More)

Elevated levels of neutrophil extracellular traps (NETs) have been reported in primary graft dysfunction, making methods to reduce or remove them highly valuable. The mechanisms behind primary graft dysfunction remain rudimentarily understood but its relation to higher rates of acute and chronic rejection necessitates the development of preventative treatments. This case series explores the use of a cytokine adsorber during lung transplantation with the focus of reducing circulating nucleosome levels as a measure of neutrophil extracellular traps. Treated patients showed reduced levels of circulating nucleosomes and remained free from primary graft dysfunction and histopathological signs of acute rejection at 1-and 3-month post-transplant. In contrast, patients without the adsorber experienced higher levels of circulating nucleosomes, primary graft dysfunction grades 1 and 3, and histopathological signs of acute rejection. Using a cytokine adsorber during transplantation may provide a reduced systemic inflammatory state with lower levels of NETs and consequently support graft acceptance.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
volume
42
issue
10
pages
1358 - 1362
publisher
Elsevier
external identifiers
  • scopus:85165272656
  • pmid:37348689
ISSN
1557-3117
DOI
10.1016/j.healun.2023.06.011
language
English
LU publication?
yes
additional info
Copyright © 2023. Published by Elsevier Inc.
id
69ccebb2-8fe5-4488-868f-4b20ec965eb6
date added to LUP
2023-06-26 20:08:58
date last changed
2024-04-20 00:09:04
@article{69ccebb2-8fe5-4488-868f-4b20ec965eb6,
  abstract     = {{<p>Elevated levels of neutrophil extracellular traps (NETs) have been reported in primary graft dysfunction, making methods to reduce or remove them highly valuable. The mechanisms behind primary graft dysfunction remain rudimentarily understood but its relation to higher rates of acute and chronic rejection necessitates the development of preventative treatments. This case series explores the use of a cytokine adsorber during lung transplantation with the focus of reducing circulating nucleosome levels as a measure of neutrophil extracellular traps. Treated patients showed reduced levels of circulating nucleosomes and remained free from primary graft dysfunction and histopathological signs of acute rejection at 1-and 3-month post-transplant. In contrast, patients without the adsorber experienced higher levels of circulating nucleosomes, primary graft dysfunction grades 1 and 3, and histopathological signs of acute rejection. Using a cytokine adsorber during transplantation may provide a reduced systemic inflammatory state with lower levels of NETs and consequently support graft acceptance.</p>}},
  author       = {{Lindstedt, Sandra and Niroomand, Anna and Mittendorfer, Margareta and Hirdman, Gabriel and Hyllén, Snejana and Pierre, Leif and Olm, Franziska}},
  issn         = {{1557-3117}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{10}},
  pages        = {{1358--1362}},
  publisher    = {{Elsevier}},
  series       = {{The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation}},
  title        = {{Nothing but NETs : Cytokine adsorption correlates with lower circulating nucleosomes and is associated with decreased primary graft dysfunction}},
  url          = {{http://dx.doi.org/10.1016/j.healun.2023.06.011}},
  doi          = {{10.1016/j.healun.2023.06.011}},
  volume       = {{42}},
  year         = {{2023}},
}