Nothing but NETs : Cytokine adsorption correlates with lower circulating nucleosomes and is associated with decreased primary graft dysfunction
(2023) In The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 42(10). p.1358-1362- Abstract
Elevated levels of neutrophil extracellular traps (NETs) have been reported in primary graft dysfunction, making methods to reduce or remove them highly valuable. The mechanisms behind primary graft dysfunction remain rudimentarily understood but its relation to higher rates of acute and chronic rejection necessitates the development of preventative treatments. This case series explores the use of a cytokine adsorber during lung transplantation with the focus of reducing circulating nucleosome levels as a measure of neutrophil extracellular traps. Treated patients showed reduced levels of circulating nucleosomes and remained free from primary graft dysfunction and histopathological signs of acute rejection at 1-and 3-month... (More)
Elevated levels of neutrophil extracellular traps (NETs) have been reported in primary graft dysfunction, making methods to reduce or remove them highly valuable. The mechanisms behind primary graft dysfunction remain rudimentarily understood but its relation to higher rates of acute and chronic rejection necessitates the development of preventative treatments. This case series explores the use of a cytokine adsorber during lung transplantation with the focus of reducing circulating nucleosome levels as a measure of neutrophil extracellular traps. Treated patients showed reduced levels of circulating nucleosomes and remained free from primary graft dysfunction and histopathological signs of acute rejection at 1-and 3-month post-transplant. In contrast, patients without the adsorber experienced higher levels of circulating nucleosomes, primary graft dysfunction grades 1 and 3, and histopathological signs of acute rejection. Using a cytokine adsorber during transplantation may provide a reduced systemic inflammatory state with lower levels of NETs and consequently support graft acceptance.
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- author
- Lindstedt, Sandra LU ; Niroomand, Anna LU ; Mittendorfer, Margareta LU ; Hirdman, Gabriel LU ; Hyllén, Snejana LU ; Pierre, Leif LU and Olm, Franziska LU
- organization
-
- Clinical and experimental lung transplantation (research group)
- LUCC: Lund University Cancer Centre
- WCMM-Wallenberg Centre for Molecular Medicine
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
- NPWT technology (research group)
- DCD transplantation of lungs (research group)
- Thoracic Surgery
- Cardiothoracic anesthesia and intensive care (research group)
- Department of Clinical Sciences, Lund
- publishing date
- 2023-06-20
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
- volume
- 42
- issue
- 10
- pages
- 1358 - 1362
- publisher
- Elsevier
- external identifiers
-
- scopus:85165272656
- pmid:37348689
- ISSN
- 1557-3117
- DOI
- 10.1016/j.healun.2023.06.011
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2023. Published by Elsevier Inc.
- id
- 69ccebb2-8fe5-4488-868f-4b20ec965eb6
- date added to LUP
- 2023-06-26 20:08:58
- date last changed
- 2024-04-20 00:09:04
@article{69ccebb2-8fe5-4488-868f-4b20ec965eb6, abstract = {{<p>Elevated levels of neutrophil extracellular traps (NETs) have been reported in primary graft dysfunction, making methods to reduce or remove them highly valuable. The mechanisms behind primary graft dysfunction remain rudimentarily understood but its relation to higher rates of acute and chronic rejection necessitates the development of preventative treatments. This case series explores the use of a cytokine adsorber during lung transplantation with the focus of reducing circulating nucleosome levels as a measure of neutrophil extracellular traps. Treated patients showed reduced levels of circulating nucleosomes and remained free from primary graft dysfunction and histopathological signs of acute rejection at 1-and 3-month post-transplant. In contrast, patients without the adsorber experienced higher levels of circulating nucleosomes, primary graft dysfunction grades 1 and 3, and histopathological signs of acute rejection. Using a cytokine adsorber during transplantation may provide a reduced systemic inflammatory state with lower levels of NETs and consequently support graft acceptance.</p>}}, author = {{Lindstedt, Sandra and Niroomand, Anna and Mittendorfer, Margareta and Hirdman, Gabriel and Hyllén, Snejana and Pierre, Leif and Olm, Franziska}}, issn = {{1557-3117}}, language = {{eng}}, month = {{06}}, number = {{10}}, pages = {{1358--1362}}, publisher = {{Elsevier}}, series = {{The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation}}, title = {{Nothing but NETs : Cytokine adsorption correlates with lower circulating nucleosomes and is associated with decreased primary graft dysfunction}}, url = {{http://dx.doi.org/10.1016/j.healun.2023.06.011}}, doi = {{10.1016/j.healun.2023.06.011}}, volume = {{42}}, year = {{2023}}, }