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Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Zamora-Ros, Raul ; Cayssials, Valerie ; Franceschi, Silvia ; Kyrø, Cecilie ; Weiderpass, Elisabete ; Hennings, Joakim ; Sandström, Maria ; Tjønneland, Anne ; Olsen, Anja and Overvad, Kim , et al. (2020) In International Journal of Cancer 146(7). p.1841-1850
Abstract

Polyphenols are bioactive compounds with several anticarcinogenic activities; however, human data regarding associations with thyroid cancer (TC) is still negligible. Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow-up of 14 years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center/country-specific dietary... (More)

Polyphenols are bioactive compounds with several anticarcinogenic activities; however, human data regarding associations with thyroid cancer (TC) is still negligible. Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow-up of 14 years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center/country-specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HRQ4 vs. Q1 = 0.99, 95% confidence interval [CI] 0.77–1.29), papillary (HRQ4 vs. Q1 = 1.06, 95% CI 0.80–1.41) or follicular TC (HRQ4 vs. Q1 = 1.10, 95% CI 0.55–2.22) were found. No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (p-trend = 0.019) and phenolic acids (p-trend = 0.007) and differentiated TC risk in subjects with BMI ≥ 25 was observed. In conclusion, our study showed no associations between dietary polyphenol intake and differentiated TC risk; although further studies are warranted to investigate the potential protective associations in overweight and obese individuals.

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published
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keywords
cohort, EPIC, flavonoids, intake, polyphenols, thyroid cancer
in
International Journal of Cancer
volume
146
issue
7
pages
10 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:85070923942
  • pmid:31342519
ISSN
0020-7136
DOI
10.1002/ijc.32589
language
English
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yes
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69f4e6ab-f9b2-426f-86e0-4e155091e3ca
date added to LUP
2019-09-12 13:12:18
date last changed
2020-02-19 05:39:15
@article{69f4e6ab-f9b2-426f-86e0-4e155091e3ca,
  abstract     = {<p>Polyphenols are bioactive compounds with several anticarcinogenic activities; however, human data regarding associations with thyroid cancer (TC) is still negligible. Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow-up of 14 years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center/country-specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HR<sub>Q4 vs. Q1</sub> = 0.99, 95% confidence interval [CI] 0.77–1.29), papillary (HR<sub>Q4 vs. Q1</sub> = 1.06, 95% CI 0.80–1.41) or follicular TC (HR<sub>Q4 vs. Q1</sub> = 1.10, 95% CI 0.55–2.22) were found. No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (p-trend = 0.019) and phenolic acids (p-trend = 0.007) and differentiated TC risk in subjects with BMI ≥ 25 was observed. In conclusion, our study showed no associations between dietary polyphenol intake and differentiated TC risk; although further studies are warranted to investigate the potential protective associations in overweight and obese individuals.</p>},
  author       = {Zamora-Ros, Raul and Cayssials, Valerie and Franceschi, Silvia and Kyrø, Cecilie and Weiderpass, Elisabete and Hennings, Joakim and Sandström, Maria and Tjønneland, Anne and Olsen, Anja and Overvad, Kim and Boutron-Ruault, Marie Christine and Truong, Thérèse and Mancini, Francesca Romana and Katzke, Verena and Kühn, Tilman and Boeing, Heiner and Trichopoulou, Antonia and Karakatsani, Anna and Martimianaki, Georgia and Palli, Domenico and Krogh, Vittorio and Panico, Salvatore and Tumino, Rosario and Sacerdote, Carlotta and Lasheras, Cristina and Rodríguez-Barranco, Miguel and Amiano, Pilar and Colorado-Yohar, Sandra M. and Ardanaz, Eva and Almquist, Martin and Ericson, Ulrika and Bueno-de-Mesquita, H. Bas and Vermeulen, Roel and Schmidt, Julie A. and Byrnes, Graham and Scalbert, Augustin and Agudo, Antonio and Rinaldi, Sabina},
  issn         = {0020-7136},
  language     = {eng},
  month        = {04},
  number       = {7},
  pages        = {1841--1850},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort},
  url          = {http://dx.doi.org/10.1002/ijc.32589},
  doi          = {10.1002/ijc.32589},
  volume       = {146},
  year         = {2020},
}